STRINGSTRING
VEGFC VEGFC PRKD2 PRKD2 MAPK3 MAPK3 CALML3 CALML3 PRKCG PRKCG CRK CRK FGF10 FGF10 PIK3R1 PIK3R1 PDGFD PDGFD FGF4 FGF4 SRC SRC PFN1-2 PFN1-2 PIK3R3 PIK3R3 PFN3 PFN3 KDR KDR EFNA4 EFNA4 SIPA1L1 SIPA1L1 GRIN2A GRIN2A ACTB ACTB LPAR5 LPAR5 RAP1A RAP1A RAPGEF2 RAPGEF2 FGF20 FGF20 EFNA3 EFNA3 RAPGEF5 RAPGEF5 ADCY6 ADCY6 FYB1 FYB1 CALML4 CALML4 ANGPT4 ANGPT4 PRKD1 PRKD1 PARD3 PARD3 LOC108534255 LOC108534255 RAP1B RAP1B P2RY1 P2RY1 PLCB1 PLCB1 RAP1GAP RAP1GAP DRD2 DRD2 IGF1 IGF1 LPAR2 LPAR2 ITGB3 ITGB3 CALM1 CALM1 VEGFD VEGFD FGF1 FGF1 RAF1 RAF1 LPAR3 LPAR3 MAGI3 MAGI3 PDGFC PDGFC FGF3 FGF3 BCAR1 BCAR1 LPAR4 LPAR4 CSF1R CSF1R FGFR2 FGFR2 MAP2K1 MAP2K1 PDGFRB PDGFRB PGF PGF INS INS ADCY7 ADCY7 EGF EGF FGF16 FGF16 KRIT1 KRIT1 PDGFB PDGFB FGF19 FGF19 FGFR1 FGFR1 MAP2K3 MAP2K3 CSF1 CSF1 PIK3CA PIK3CA EPHA2 EPHA2 PARD6B PARD6B LCP2 LCP2 TIAM1 TIAM1 RASSF5 RASSF5 PRKCA PRKCA MAP2K6 MAP2K6 ADCY9 ADCY9 SIPA1L2 SIPA1L2 ITGB1 ITGB1 BRAF BRAF ADCY3 ADCY3 HRAS HRAS VEGFB VEGFB CTNNB1 CTNNB1 EFNA5 EFNA5 ITGA2B ITGA2B ADCY8 ADCY8 MAGI1 MAGI1 ADCY2 ADCY2 ADORA2A ADORA2A ITGAL ITGAL F2R F2R FLT1 FLT1 MAPK1 MAPK1 KRAS KRAS FGF7 FGF7 PDGFA PDGFA RALB RALB RGL4 RGL4 FGF23 FGF23 MAPK14 MAPK14 RASGRP3 RASGRP3 KIT KIT TEK TEK FGF8 FGF8 MRAS MRAS PARD6G PARD6G CRKL CRKL ID1 ID1 SIPA1L3 SIPA1L3 FGF9 FGF9 GNAI2 GNAI2 FGF6 FGF6 FGF17 FGF17 RALA RALA RALGDS RALGDS MAPK13 MAPK13 CALM3 CALM3 FGFR3 FGFR3 MET MET RASGRP2 RASGRP2 AKT2 AKT2 ADCY5 ADCY5 AKT3 AKT3 MAPK11 MAPK11 ADORA2B ADORA2B VAV1 VAV1 PIK3CD PIK3CD FGF5 FGF5 ADCY1 ADCY1 PFN2 PFN2 ITGAM ITGAM FLT4 FLT4 LOC108513979 LOC108513979 GNAS GNAS GNAQ GNAQ EGFR EGFR FGF18 FGF18 PDGFRA PDGFRA CDC42 CDC42 ANGPT1 ANGPT1 PLCB2 PLCB2 RAPGEF4 RAPGEF4 SKAP1 SKAP1 PLCB4 PLCB4 PLCG1 PLCG1 GRIN1 GRIN1 PRKCI PRKCI NRAS NRAS RAC2 RAC2 HGF HGF ANGPT2 ANGPT2 PRKD3 PRKD3 CNR1 CNR1 LAT LAT GNAI3 GNAI3 NGF NGF THBS1 THBS1 CTNND1 CTNND1 PARD6A PARD6A ARAP3 ARAP3 GRIN2B GRIN2B TLN1 TLN1 LOC108541626 LOC108541626 EFNA1 EFNA1 IGF1R IGF1R RHOA RHOA RRAS RRAS TLN2 TLN2 NGFR NGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (350 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PRKCGProtein kinase C. (726 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PDGFDPlatelet derived growth factor D. (398 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
SRCTyrosine-protein kinase. (627 aa)
PFN1-2Profilin; Belongs to the profilin family. (140 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (201 aa)
SIPA1L1Signal induced proliferation associated 1 like 1. (1804 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
ACTBActin beta. (379 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1474 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
EFNA3Ephrin A3; Belongs to the ephrin family. (238 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (638 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1169 aa)
FYB1FYN binding protein 1. (839 aa)
CALML4Calmodulin like 4. (192 aa)
ANGPT4Angiopoietin 4. (503 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (892 aa)
PARD3Par-3 family cell polarity regulator. (1356 aa)
LOC108534255G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (443 aa)
RAP1BUncharacterized protein. (184 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1079 aa)
RAP1GAPRAP1 GTPase activating protein. (826 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
IGF1Insulin like growth factor 1. (208 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
RAF1Uncharacterized protein. (668 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (341 aa)
MAGI3Membrane associated guanylate kinase, WW and PDZ domain containing 3. (1482 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (906 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (974 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
KRIT1Uncharacterized protein. (736 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (237 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGFR1Fibroblast growth factor receptor. (829 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
CSF1Colony stimulating factor 1. (587 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
EPHA2EPH receptor A2. (1036 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
LCP2Lymphocyte cytosolic protein 2. (531 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
RASSF5Ras association domain family member 5. (418 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (604 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
SIPA1L2Signal induced proliferation associated 1 like 2. (1733 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (937 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (753 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
VEGFBVascular endothelial growth factor B. (183 aa)
CTNNB1Catenin beta 1. (781 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1105 aa)
ADCY8Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (657 aa)
MAGI1Membrane associated guanylate kinase, WW and PDZ domain containing 1. (1160 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1155 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (303 aa)
RALBRAS like proto-oncogene B. (212 aa)
RGL4Ral guanine nucleotide dissociation stimulator like 4. (471 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RASGRP3RAS guanyl releasing protein 3. (755 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
TEKTEK receptor tyrosine kinase. (1123 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
PARD6GPar-6 family cell polarity regulator gamma. (376 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
SIPA1L3Signal induced proliferation associated 1 like 3. (1739 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GNAI2G protein subunit alpha i2. (355 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
RALARAS like proto-oncogene A. (206 aa)
RALGDSUncharacterized protein. (918 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (163 aa)
FGFR3Fibroblast growth factor receptor. (783 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1383 aa)
RASGRP2RAS guanyl releasing protein 2. (610 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (394 aa)
VAV1Vav guanine nucleotide exchange factor 1. (843 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
PFN2Profilin; Belongs to the profilin family. (183 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1329 aa)
LOC108513979G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (266 aa)
GNASGNAS complex locus. (1041 aa)
GNAQG protein subunit alpha q. (359 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CDC42Uncharacterized protein. (191 aa)
ANGPT1Angiopoietin 1. (498 aa)
PLCB2Phosphoinositide phospholipase C. (991 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (882 aa)
SKAP1Src kinase associated phosphoprotein 1. (397 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1199 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (581 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAC2Rac family small GTPase 2. (192 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
ANGPT2Angiopoietin 2. (510 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa)
CNR1Uncharacterized protein. (36 aa)
LATLinker for activation of T cells. (254 aa)
GNAI3G protein subunit alpha i3. (354 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
THBS1Thrombospondin 1. (1170 aa)
CTNND1Catenin delta 1. (968 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
ARAP3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1531 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
TLN1Talin 1. (2562 aa)
LOC108541626Uncharacterized protein. (246 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (156 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
RHOAUncharacterized protein. (104 aa)
RRASRAS related. (218 aa)
TLN2Talin 2. (2536 aa)
NGFRNerve growth factor receptor. (427 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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