STRINGSTRING
SRF SRF MAPK3 MAPK3 CALML3 CALML3 ATP2B2 ATP2B2 ENSRBIP00000002156 ENSRBIP00000002156 PDE2A PDE2A PPP3CA PPP3CA LOC108512004 LOC108512004 PPP3CB PPP3CB CREB3L2 CREB3L2 ATP1A1 ATP1A1 SLC8A1 SLC8A1 GNA11 GNA11 ADCY6 ADCY6 ADORA1 ADORA1 CALML4 CALML4 ATF6B ATF6B SLC25A31 SLC25A31 CACNA1S CACNA1S PLCB1 PLCB1 SLC8A3 SLC8A3 KNG1 KNG1 PLN PLN NPR2 NPR2 MYLK3 MYLK3 TMIGD3 TMIGD3 ATP1B3 ATP1B3 NFATC4 NFATC4 MYL9 MYL9 CALM1 CALM1 VDAC1 VDAC1 GNA13 GNA13 ATP1A4 ATP1A4 ROCK1 ROCK1 NFATC2 NFATC2 NFATC3 NFATC3 ADRA2B ADRA2B PPP1CB PPP1CB RAF1 RAF1 PPP3CC PPP3CC GTF2IRD1 GTF2IRD1 MEF2A MEF2A CREB3L1 CREB3L1 PPIF PPIF SLC8A2 SLC8A2 EDNRA EDNRA ATP2B3 ATP2B3 IRS1 IRS1 KCNMB1 KCNMB1 PPP1CC PPP1CC PIK3R6 PIK3R6 MAP2K1 MAP2K1 ATP2B4 ATP2B4 INS INS ADCY7 ADCY7 IRS2 IRS2 ATF4 ATF4 SLC25A4 SLC25A4 ATP2B1 ATP2B1 VDAC2 VDAC2 RGS2 RGS2 NPPC NPPC CNGA1 CNGA1 GNA12 GNA12 ADCY9 ADCY9 EDNRB EDNRB CACNA1D CACNA1D ADCY3 ADCY3 ITPR2 ITPR2 MYLK MYLK ITPR1 ITPR1 ADCY8 ADCY8 MYLK2 MYLK2 ATP2A2 ATP2A2 CREB3 CREB3 ADCY2 ADCY2 PRKG2 PRKG2 MYLK4 MYLK4 SLC25A6 SLC25A6 MAPK1 MAPK1 GUCY1A1 GUCY1A1 NFATC1 NFATC1 ATP1B4 ATP1B4 VDAC3 VDAC3 TRPC6 TRPC6 GNAI2 GNAI2 PDE5A PDE5A CREB5 CREB5 MRVI1 MRVI1 CALM3 CALM3 NPR1 NPR1 KCNMB2 KCNMB2 ATP1B1 ATP1B1 CREB1 CREB1 GATA4 GATA4 AKT2 AKT2 NOS3 NOS3 ADCY5 ADCY5 AKT3 AKT3 CACNA1F CACNA1F ADCY1 ADCY1 AGTR1 AGTR1 CNGB1 CNGB1 ADRA2A ADRA2A GNAQ GNAQ IRS4 IRS4 PLCB2 PLCB2 KCNU1 KCNU1 PLCB4 PLCB4 ATP2A1 ATP2A1 ADRA1A ADRA1A GNAI3 GNAI3 CREB3L3 CREB3L3 PRKCE PRKCE PIK3CG PIK3CG ATP1B2 ATP1B2 PPP1CA PPP1CA ITPR3 ITPR3 RHOA RHOA BAD BAD OPRD1 OPRD1 KCNJ8 KCNJ8 ADRB2 ADRB2 ROCK2 ROCK2 PIK3R5 PIK3R5 MYH7 MYH7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRFSerum response factor. (508 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1270 aa)
ENSRBIP00000002156Uncharacterized protein. (366 aa)
PDE2APhosphodiesterase. (944 aa)
PPP3CASerine/threonine-protein phosphatase. (310 aa)
LOC108512004Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1034 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
GNA11G protein subunit alpha 11. (354 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1169 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
CALML4Calmodulin like 4. (192 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (314 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1079 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
KNG1Kininogen 1. (644 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
NPR2Guanylate cyclase. (1047 aa)
MYLK3Myosin light chain kinase 3. (818 aa)
TMIGD3Transmembrane and immunoglobulin domain containing 3; Belongs to the G-protein coupled receptor 1 family. (347 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (265 aa)
NFATC4Nuclear factor of activated T cells 4. (909 aa)
MYL9Myosin light chain 9. (172 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
VDAC1Voltage dependent anion channel 1. (299 aa)
GNA13G protein subunit alpha 13. (353 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1341 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
NFATC3Nuclear factor of activated T cells 3. (1056 aa)
ADRA2BAdrenoceptor alpha 2B. (451 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
RAF1Uncharacterized protein. (668 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
GTF2IRD1GTF2I repeat domain containing 1. (980 aa)
MEF2AMyocyte enhancer factor 2A. (511 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (442 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (206 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (907 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (426 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
IRS2Insulin receptor substrate 2. (904 aa)
ATF4Activating transcription factor 4. (351 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1071 aa)
VDAC2Voltage dependent anion channel 2. (308 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
NPPCNatriuretic peptide C. (126 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (745 aa)
GNA12G protein subunit alpha 12. (322 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (507 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2180 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2637 aa)
MYLKMyosin light chain kinase. (1656 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
ADCY8Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (657 aa)
MYLK2Myosin light chain kinase 2. (603 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1037 aa)
CREB3cAMP responsive element binding protein 3. (370 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PRKG2cGMP-dependent protein kinase. (725 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (388 aa)
SLC25A6Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
NFATC1Nuclear factor of activated T cells 1. (989 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (353 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
TRPC6Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (827 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PDE5APhosphodiesterase. (876 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (503 aa)
MRVI1Murine retrovirus integration site 1 homolog. (911 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (163 aa)
NPR1Guanylate cyclase. (1061 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (235 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GATA4GATA binding protein 4. (432 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1818 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
CNGB1Cyclic nucleotide gated channel subunit beta 1. (1236 aa)
ADRA2AAdrenoceptor alpha 2A. (400 aa)
GNAQG protein subunit alpha q. (359 aa)
IRS4Insulin receptor substrate 4. (1247 aa)
PLCB2Phosphoinositide phospholipase C. (991 aa)
KCNU1Potassium calcium-activated channel subfamily U member 1. (1149 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1199 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1027 aa)
ADRA1AAdrenoceptor alpha 1A. (455 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (483 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
RHOAUncharacterized protein. (104 aa)
BADBCL2 associated agonist of cell death. (167 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
ADRB2Adrenoceptor beta 2. (399 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1387 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (879 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
Server load: low (18%) [HD]