92 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TICAM2	Toll like receptor adaptor molecule 2. (235 aa)
	LY96	Lymphocyte antigen 96. (160 aa)
	TNFRSF13C	TNF receptor superfamily member 13C. (140 aa)
	UBE2I	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (231 aa)
	BIRC3	Baculoviral IAP repeat containing 3. (604 aa)
	CARD11	Caspase recruitment domain family member 11. (1154 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	PLAU	Plasminogen activator, urokinase. (431 aa)
	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (512 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (906 aa)
	TNFRSF11A	TNF receptor superfamily member 11a. (614 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
	IL1R1	Interleukin 1 receptor type 1. (568 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (563 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
	CARD10	Caspase recruitment domain family member 10. (1043 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	TRAF1	TNF receptor-associated factor. (416 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	BIRC2	Baculoviral IAP repeat containing 2. (618 aa)
	CSNK2A2	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	CCL21	C-C motif chemokine ligand 21. (131 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
	MALT1	MALT1 paracaspase. (811 aa)
	LTBR	Lymphotoxin beta receptor. (370 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	RELA	Uncharacterized protein. (282 aa)
	LOC108513563	C-X-C motif chemokine. (103 aa)
	LTA	Lymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
	VCAM1	Vascular cell adhesion molecule 1. (739 aa)
	TIRAP	TIR domain containing adaptor protein. (233 aa)
	TRADD	TNFRSF1A associated via death domain. (248 aa)
	TNFAIP3	TNF alpha induced protein 3. (790 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3026 aa)
	ENSRBIP00000020710	Ig-like domain-containing protein. (124 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (317 aa)
	CD14	CD14 molecule. (384 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (160 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
	SYK	Uncharacterized protein. (331 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (947 aa)
	LOC108523516	C-X-C motif chemokine. (107 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (159 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (948 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (317 aa)
	ZAP70	Tyrosine-protein kinase. (619 aa)
	CSNK2B	Uncharacterized protein. (298 aa)
	BCL2A1	BCL2 related protein A1. (175 aa)
	CCL13	C-C motif chemokine. (98 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
	CXCL2	C-X-C motif chemokine. (107 aa)
	LOC108522153	Ig-like domain-containing protein. (198 aa)
	LOC108541410	SCY domain-containing protein. (102 aa)
	CCL19	C-C motif chemokine. (98 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	RELB	RELB proto-oncogene, NF-kB subunit. (541 aa)
	CARD14	Caspase recruitment domain family member 14. (1004 aa)
	EDARADD	EDAR associated death domain. (215 aa)
	ICAM1	Intercellular adhesion molecule 1. (532 aa)
	DDX58	DExD/H-box helicase 58. (914 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
	LOC108516810	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (330 aa)
	CD40	CD40 molecule. (278 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	LTB	Lymphotoxin beta; Belongs to the tumor necrosis factor family. (244 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (690 aa)
	PIAS4	Protein inhibitor of activated STAT 4. (508 aa)
	LBP	Lipopolysaccharide binding protein. (481 aa)
	TRIM25	Tripartite motif containing 25. (630 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (461 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (165 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (455 aa)
	NFKBIA	NFKB inhibitor alpha. (317 aa)
	LOC108539235	C-X-C motif chemokine. (100 aa)
	PIDD1	P53-induced death domain protein 1. (887 aa)
	LAT	Linker for activation of T cells. (254 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (672 aa)
	BCL10	BCL10 immune signaling adaptor. (233 aa)
	BLNK	B cell linker. (456 aa)
	TRAF3	TNF receptor-associated factor. (477 aa)
	BTK	Tyrosine-protein kinase. (673 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	BCL2	ENSRBIP00000020338	ENSRBIP00000010712	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BCL2 apoptosis regulator.	0.434
ATM	BTK	ENSRBIP00000020338	ENSRBIP00000042366	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.425
ATM	CHUK	ENSRBIP00000020338	ENSRBIP00000023948	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Component of inhibitor of nuclear factor kappa B kinase complex.	0.442
ATM	IKBKB	ENSRBIP00000020338	ENSRBIP00000027811	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.425
ATM	IKBKG	ENSRBIP00000020338	ENSRBIP00000015173	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.811
ATM	MAP3K7	ENSRBIP00000020338	ENSRBIP00000005150	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.452
ATM	NFKB1	ENSRBIP00000020338	ENSRBIP00000012337	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Nuclear factor kappa B subunit 1.	0.469
ATM	PARP1	ENSRBIP00000020338	ENSRBIP00000043459	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.503
ATM	PIAS4	ENSRBIP00000020338	ENSRBIP00000037357	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein inhibitor of activated STAT 4.	0.833
ATM	PIDD1	ENSRBIP00000020338	ENSRBIP00000040247	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	P53-induced death domain protein 1.	0.730
ATM	UBE2I	ENSRBIP00000020338	ENSRBIP00000002784	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.636
BCL10	BCL2	ENSRBIP00000041432	ENSRBIP00000010712	BCL10 immune signaling adaptor.	BCL2 apoptosis regulator.	0.427
BCL10	BIRC2	ENSRBIP00000041432	ENSRBIP00000011618	BCL10 immune signaling adaptor.	Baculoviral IAP repeat containing 2.	0.579
BCL10	BIRC3	ENSRBIP00000041432	ENSRBIP00000003782	BCL10 immune signaling adaptor.	Baculoviral IAP repeat containing 3.	0.687
BCL10	CARD10	ENSRBIP00000041432	ENSRBIP00000010547	BCL10 immune signaling adaptor.	Caspase recruitment domain family member 10.	0.807
BCL10	CARD11	ENSRBIP00000041432	ENSRBIP00000004497	BCL10 immune signaling adaptor.	Caspase recruitment domain family member 11.	0.994
BCL10	CARD14	ENSRBIP00000041432	ENSRBIP00000031620	BCL10 immune signaling adaptor.	Caspase recruitment domain family member 14.	0.781
BCL10	CHUK	ENSRBIP00000041432	ENSRBIP00000023948	BCL10 immune signaling adaptor.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.976
BCL10	DDX58	ENSRBIP00000041432	ENSRBIP00000032975	BCL10 immune signaling adaptor.	DExD/H-box helicase 58.	0.583
BCL10	IKBKB	ENSRBIP00000041432	ENSRBIP00000027811	BCL10 immune signaling adaptor.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.983