STRINGSTRING
MAPK3 MAPK3 CTSD CTSD PRKCG PRKCG PIK3R1 PIK3R1 PIK3R3 PIK3R3 S1PR1 S1PR1 MAPK10 MAPK10 S1PR3 S1PR3 FCER1A FCER1A S1PR2 S1PR2 ADORA1 ADORA1 NSMAF NSMAF FYN FYN PPP2R5D PPP2R5D MAPK9 MAPK9 PLCB1 PLCB1 KNG1 KNG1 CERS4 CERS4 PPP2R1B PPP2R1B TMIGD3 TMIGD3 BID BID PPP2R2A PPP2R2A GNA13 GNA13 SPTLC2 SPTLC2 PPP2R1A PPP2R1A FCER1G FCER1G ROCK1 ROCK1 BCL2 BCL2 RAF1 RAF1 TNF TNF CERS2 CERS2 NFKB1 NFKB1 CERS5 CERS5 PPP2R5B PPP2R5B MAP2K1 MAP2K1 GAB2 GAB2 SGPP2 SGPP2 PIK3CA PIK3CA RELA RELA PPP2R2C PPP2R2C DEGS1 DEGS1 SMPD2 SMPD2 TRADD TRADD GNA12 GNA12 PRKCA PRKCA ACER2 ACER2 HRAS HRAS PPP2R5E PPP2R5E ASAH2 ASAH2 ACER1 ACER1 CERS3 CERS3 SPHK2 SPHK2 SPHK1 SPHK1 SMPD1 SMPD1 MS4A2 MS4A2 CERS1 CERS1 CERS6 CERS6 MAPK1 MAPK1 KRAS KRAS SGMS2 SGMS2 PPP2R2D PPP2R2D MAPK14 MAPK14 TP53 TP53 SPTLC3 SPTLC3 MAP3K5 MAP3K5 GNAI2 GNAI2 PPP2R3A PPP2R3A TRAF2 TRAF2 MAPK13 MAPK13 AKT2 AKT2 NOS3 NOS3 AKT3 AKT3 MAPK11 MAPK11 PTEN PTEN PIK3CD PIK3CD BAX BAX GNAQ GNAQ PPP2R2B PPP2R2B PLCB2 PLCB2 SGPL1 SGPL1 PLCB4 PLCB4 TNFRSF1A TNFRSF1A DEGS2 DEGS2 NRAS NRAS PPP2R5C PPP2R5C SPTLC1 SPTLC1 RAC2 RAC2 ENSRBIP00000040138 ENSRBIP00000040138 GNAI3 GNAI3 PRKCE PRKCE PLD1 PLD1 ABCC1 ABCC1 RHOA RHOA OPRD1 OPRD1 ROCK2 ROCK2 PPP2CA PPP2CA ASAH1 ASAH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (371 aa)
PRKCGProtein kinase C. (726 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
FCER1AFc fragment of IgE receptor Ia. (260 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
NSMAFUncharacterized protein. (927 aa)
FYNTyrosine-protein kinase. (537 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1079 aa)
KNG1Kininogen 1. (644 aa)
CERS4Ceramide synthase 4. (393 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
TMIGD3Transmembrane and immunoglobulin domain containing 3; Belongs to the G-protein coupled receptor 1 family. (347 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
GNA13G protein subunit alpha 13. (353 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (565 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
FCER1GFc fragment of IgE receptor Ig. (112 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1341 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
RAF1Uncharacterized protein. (668 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CERS2Ceramide synthase 2. (423 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CERS5Ceramide synthase 5. (326 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (595 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GAB2GRB2 associated binding protein 2. (678 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (399 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
RELAUncharacterized protein. (282 aa)
PPP2R2CProtein phosphatase 2 regulatory subunit Bgamma. (282 aa)
DEGS1Delta 4-desaturase, sphingolipid 1. (323 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (423 aa)
TRADDTNFRSF1A associated via death domain. (248 aa)
GNA12G protein subunit alpha 12. (322 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (604 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
ASAH2Neutral ceramidase. (780 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
CERS3Ceramide synthase 3. (385 aa)
SPHK2Sphingosine kinase 2. (658 aa)
SPHK1Sphingosine kinase 1. (384 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
MS4A2Membrane spanning 4-domains A2. (260 aa)
CERS1TLC domain-containing protein. (319 aa)
CERS6Ceramide synthase 6. (396 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (552 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1098 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PTENUncharacterized protein. (555 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
GNAQG protein subunit alpha q. (359 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
PLCB2Phosphoinositide phospholipase C. (991 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1199 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (352 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (571 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (473 aa)
RAC2Rac family small GTPase 2. (192 aa)
ENSRBIP00000040138SAM domain-containing protein. (241 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PLD1Phospholipase. (968 aa)
ABCC1ATP binding cassette subfamily C member 1. (1531 aa)
RHOAUncharacterized protein. (104 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1387 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (411 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.