STRINGSTRING
CDKN1C CDKN1C CDKN1B CDKN1B YWHAH YWHAH ESPL1 ESPL1 STAG1 STAG1 CDC14A CDC14A ORC6 ORC6 RBL2 RBL2 E2F5 E2F5 TGFB2 TGFB2 SFN SFN CDC20 CDC20 LOC108544295 LOC108544295 CDKN2D CDKN2D SMC1A SMC1A ORC1 ORC1 YWHAQ YWHAQ TGFB1 TGFB1 PCNA PCNA CDC16 CDC16 TFDP2 TFDP2 ABL1 ABL1 BUB1 BUB1 ANAPC10 ANAPC10 CDK7 CDK7 DBF4 DBF4 CCNB3 CCNB3 MAD1L1 MAD1L1 SMAD2 SMAD2 BUB3 BUB3 TFDP1 TFDP1 CUL1 CUL1 PRKDC PRKDC SMC1B SMC1B WEE2 WEE2 ZBTB17 ZBTB17 CCNB1 CCNB1 LOC108527145 LOC108527145 MCM7 MCM7 PKMYT1 PKMYT1 ORC2 ORC2 SMAD4 SMAD4 CDK4 CDK4 RB1 RB1 ENSRBIP00000020047 ENSRBIP00000020047 CCNB2 CCNB2 ATM ATM MCM2 MCM2 CDC25B CDC25B HDAC1 HDAC1 MAD2L1 MAD2L1 LOC108522364 LOC108522364 GADD45B GADD45B RBL1 RBL1 MCM5 MCM5 YWHAZ YWHAZ CDC23 CDC23 HDAC2 HDAC2 CCNA1 CCNA1 GSK3B GSK3B GADD45G GADD45G MCM3 MCM3 CCND1 CCND1 CDKN2C CDKN2C TGFB3 TGFB3 ANAPC5 ANAPC5 ATR ATR MCM4 MCM4 ORC5 ORC5 CCND3 CCND3 TP53 TP53 CCNH CCNH MCM6 MCM6 ORC4 ORC4 CREBBP CREBBP SKP2 SKP2 YWHAE YWHAE E2F2 E2F2 CDC14B CDC14B CDC14C CDC14C MYC MYC FZR1 FZR1 EP300 EP300 E2F4 E2F4 CDC7 CDC7 CCNE2 CCNE2 ANAPC2 ANAPC2 YWHAB YWHAB CCNA2 CCNA2 CDC6 CDC6 BUB1B BUB1B GADD45A GADD45A CCND2 CCND2 E2F3 E2F3 RBX1 RBX1 ANAPC4 ANAPC4 SMC3 SMC3 CDK1 CDK1 ANAPC1 ANAPC1 CDK6 CDK6 ANAPC7 ANAPC7 CDC26 CDC26
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDKN1CUncharacterized protein. (142 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (241 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2120 aa)
STAG1Stromal antigen 1. (1219 aa)
CDC14ACell division cycle 14A. (619 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
RBL2RB transcriptional corepressor like 2. (1127 aa)
E2F5E2F transcription factor 5. (345 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
CDC20Cell division cycle 20. (499 aa)
LOC108544295Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (253 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CDC16Cell division cycle 16. (620 aa)
TFDP2Transcription factor. (429 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1096 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (184 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
DBF4DBF4 zinc finger. (648 aa)
CCNB3Uncharacterized protein; Belongs to the cyclin family. (223 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (766 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
BUB3WD_REPEATS_REGION domain-containing protein. (328 aa)
TFDP1Transcription factor. (410 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
SMC1BStructural maintenance of chromosomes protein. (1193 aa)
WEE2Wee1-like protein kinase. (567 aa)
ZBTB17Zinc finger and BTB domain containing 17. (803 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (433 aa)
LOC108527145Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (469 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
PKMYT1Protein kinase, membrane associated tyrosine/threonine 1. (568 aa)
ORC2Origin recognition complex subunit 2. (575 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RB1RB transcriptional corepressor 1. (815 aa)
ENSRBIP00000020047Uncharacterized protein; Belongs to the SKP1 family. (162 aa)
CCNB2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (398 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3026 aa)
MCM2DNA helicase; Belongs to the MCM family. (907 aa)
CDC25BCell division cycle 25B. (580 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
MAD2L1HORMA domain-containing protein. (205 aa)
LOC108522364Uncharacterized protein. (389 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
RBL1RB transcriptional corepressor like 1. (1069 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
YWHAZ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (151 aa)
CDC23Cell division cycle 23. (597 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MCM3DNA helicase; Belongs to the MCM family. (828 aa)
CCND1Cyclin D1. (156 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2578 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
ORC5Origin recognition complex subunit 5. (424 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (286 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CCNHCyclin H; Belongs to the cyclin family. (325 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (435 aa)
CREBBPCREB binding protein. (2422 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
YWHAE14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
E2F2E2F transcription factor 2. (437 aa)
CDC14BCell division cycle 14B. (498 aa)
CDC14CCell division cycle 14C. (551 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
FZR1Fizzy and cell division cycle 20 related 1. (496 aa)
EP300E1A binding protein p300. (2296 aa)
E2F4E2F transcription factor 4. (415 aa)
CDC7Cell division cycle 7. (574 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (403 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
BUB1BBUB1 N-terminal domain-containing protein. (1050 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CCND2Uncharacterized protein; Belongs to the cyclin family. (244 aa)
E2F3E2F transcription factor 3. (465 aa)
RBX1Ring-box 1. (108 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (807 aa)
SMC3Structural maintenance of chromosomes protein. (1208 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
ANAPC1Anaphase promoting complex subunit 1. (1944 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
ANAPC7Anaphase promoting complex subunit 7. (498 aa)
CDC26Cell division cycle 26. (85 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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