STRINGSTRING
LPIN1 LPIN1 MAPK3 MAPK3 RRAGA RRAGA ATP6V1E2 ATP6V1E2 PRKCG PRKCG WNT6 WNT6 PIK3R1 PIK3R1 LAMTOR3 LAMTOR3 WNT3 WNT3 PIK3R3 PIK3R3 MLST8 MLST8 RPS6KA2 RPS6KA2 RRAGC RRAGC FZD9 FZD9 MTOR MTOR FZD5 FZD5 CASTOR1 CASTOR1 FZD10 FZD10 RHEB RHEB SEC13 SEC13 STK11 STK11 WNT2B WNT2B ATP6V1H ATP6V1H DEPTOR DEPTOR SLC38A9 SLC38A9 IGF1 IGF1 RPS6KA1 RPS6KA1 SESN2 SESN2 DVL3 DVL3 LAMTOR1 LAMTOR1 LOC108513197 LOC108513197 RAF1 RAF1 TNF TNF AKT1S1 AKT1S1 EIF4EBP1 EIF4EBP1 RNF152 RNF152 IRS1 IRS1 FZD7 FZD7 WDR59 WDR59 ATP6V1G2 ATP6V1G2 RPS6KA3 RPS6KA3 LAMTOR4-2 LAMTOR4-2 CAB39L CAB39L MAP2K1 MAP2K1 WNT10B WNT10B INS INS ATP6V1C2 ATP6V1C2 FLCN FLCN DVL2 DVL2 DEPDC5 DEPDC5 CAB39 CAB39 GRB2 GRB2 SLC7A5 SLC7A5 SEH1L SEH1L LPIN2 LPIN2 PIK3CA PIK3CA TBC1D7 TBC1D7 ATP6V1C1 ATP6V1C1 PRKCA PRKCA STRADA STRADA BRAF BRAF ATP6V1B1 ATP6V1B1 HRAS HRAS LRP6 LRP6 MIOS MIOS WNT8B WNT8B DDIT4 DDIT4 ATP6V1A ATP6V1A TSC1 TSC1 CHUK CHUK GSK3B GSK3B WNT16 WNT16 WNT9A WNT9A WNT5B WNT5B PRKAA1 PRKAA1 WNT8A WNT8A MAPK1 MAPK1 FNIP2 FNIP2 KRAS KRAS WNT9B WNT9B NPRL3 NPRL3 FZD4 FZD4 IKBKB IKBKB TELO2 TELO2 EIF4E EIF4E EIF4E1B EIF4E1B TTI1 TTI1 SKP2 SKP2 RICTOR RICTOR SLC3A2 SLC3A2 WNT3A WNT3A ULK2 ULK2 TSC2 TSC2 FZD3 FZD3 WNT1 WNT1 NPRL2 NPRL2 SGK1 SGK1 SOS1 SOS1 WNT7B WNT7B FNIP1 FNIP1 AKT2 AKT2 AKT3 AKT3 PTEN PTEN PIK3CD PIK3CD GRB10 GRB10 LAMTOR5 LAMTOR5 SOS2 SOS2 PRR5 PRR5 ULK1 ULK1 PRKAA2 PRKAA2 WNT11 WNT11 TNFRSF1A TNFRSF1A ATP6V1B2 ATP6V1B2 NRAS NRAS LAMTOR2 LAMTOR2 WNT7A WNT7A ATP6V1G1 ATP6V1G1 EIF4B EIF4B WNT5A WNT5A MAPKAP1 MAPKAP1 WNT2 WNT2 IGF1R IGF1R RHOA RHOA CASTOR2 CASTOR2 FZD6 FZD6 EIF4E2 EIF4E2 WNT10A WNT10A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LPIN1Lipin 1. (975 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
RRAGARas related GTP binding A. (313 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
PRKCGProtein kinase C. (726 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
RRAGCRas related GTP binding C. (392 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (331 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
RHEBRas homolog, mTORC1 binding. (183 aa)
SEC13WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family. (368 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
DEPTORDEP domain containing MTOR interacting protein. (409 aa)
SLC38A9Solute carrier family 38 member 9. (561 aa)
IGF1Insulin like growth factor 1. (208 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
SESN2Sestrin 2. (450 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
LOC10851319740S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
RAF1Uncharacterized protein. (668 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
AKT1S1AKT1 substrate 1. (276 aa)
EIF4EBP1Uncharacterized protein. (118 aa)
RNF152Ring finger protein 152. (203 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
WDR59WD repeat domain 59. (947 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa)
RPS6KA3Uncharacterized protein. (66 aa)
LAMTOR4-2Uncharacterized protein. (99 aa)
CAB39LCalcium binding protein 39 like. (359 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (427 aa)
FLCNFolliculin. (579 aa)
DVL2Dishevelled segment polarity protein 2. (735 aa)
DEPDC5DEP domain-containing protein. (1593 aa)
CAB39Calcium binding protein 39. (341 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (384 aa)
LPIN2Lipin 2. (933 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
TBC1D7TBC1 domain family member 7. (293 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (604 aa)
STRADASTE20 related adaptor alpha. (419 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (753 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
MIOSMeiosis regulator for oocyte development. (875 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
DDIT4DNA damage inducible transcript 4. (233 aa)
ATP6V1AUncharacterized protein. (617 aa)
TSC1TSC complex subunit 1. (1164 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (467 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
FNIP2Folliculin interacting protein 2. (1213 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (562 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
TELO2Telomere maintenance 2. (836 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (240 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
TTI1TELO2 interacting protein 1. (1089 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1729 aa)
SLC3A2Solute carrier family 3 member 2. (631 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ULK2Unc-51 like autophagy activating kinase 2. (593 aa)
TSC2TSC complex subunit 2. (1805 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1293 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
FNIP1Folliculin interacting protein 1. (1166 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
PTENUncharacterized protein. (555 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GRB10Growth factor receptor bound protein 10. (593 aa)
LAMTOR5Uncharacterized protein. (169 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1268 aa)
PRR5Proline rich 5. (410 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1044 aa)
PRKAA2Non-specific serine/threonine protein kinase. (539 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (540 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (344 aa)
ATP6V1G1V-type H+-transporting ATPase subunit G. (118 aa)
EIF4BEukaryotic translation initiation factor 4B. (617 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
RHOAUncharacterized protein. (104 aa)
CASTOR2Uncharacterized protein. (291 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (647 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (244 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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