STRINGSTRING
SREBF1 SREBF1 PRKAG3 PRKAG3 PIK3R1 PIK3R1 PIK3R3 PIK3R3 EEF2K EEF2K CREB3L2 CREB3L2 MTOR MTOR MAP3K7 MAP3K7 PFKL PFKL LIPE LIPE RHEB RHEB FOXO1 FOXO1 PPP2R5D PPP2R5D STK11 STK11 PPP2R1B PPP2R1B IGF1 IGF1 PPP2R2A PPP2R2A PRKAG1 PRKAG1 CD36 CD36 PPP2R1A PPP2R1A SIRT1 SIRT1 PRKAB2 PRKAB2 AKT1S1 AKT1S1 MLYCD MLYCD ADIPOQ ADIPOQ CREB3L1 CREB3L1 FBP2 FBP2 EIF4EBP1 EIF4EBP1 IRS1 IRS1 PPP2R5B PPP2R5B SCD5 SCD5 CAB39L CAB39L PFKFB2 PFKFB2 PFKFB3 PFKFB3 INS INS CAB39 CAB39 IRS2 IRS2 PPARGC1A PPARGC1A ELAVL1 ELAVL1 PCK1 PCK1 PIK3CA PIK3CA PPP2R2C PPP2R2C GYS1 GYS1 PFKFB4 PFKFB4 SLC2A4 SLC2A4 PRKAB1 PRKAB1 STRADA STRADA CPT1C CPT1C GYS2 GYS2 ADIPOR1 ADIPOR1 CRTC2 CRTC2 FBP1 FBP1 PPP2R5E PPP2R5E G6PC3 G6PC3 FASN FASN TSC1 TSC1 CREB3 CREB3 CCNA1 CCNA1 RAB14 RAB14 PFKFB1 PFKFB1 HNF4A HNF4A PRKAA1 PRKAA1 SCD SCD CCND1 CCND1 HMGCR HMGCR PPP2R2D PPP2R2D RAB2A RAB2A CFTR CFTR LEPR LEPR PFKM PFKM PPP2R3A PPP2R3A RAB8A RAB8A CREB5 CREB5 TSC2 TSC2 LOC108520497 LOC108520497 CREB1 CREB1 AKT2 AKT2 AKT3 AKT3 FOXO3 FOXO3 PIK3CD PIK3CD PCK2 PCK2 ACACB ACACB CCNA2 CCNA2 ADIPOR2 ADIPOR2 IRS4 IRS4 PPP2R2B PPP2R2B ULK1 ULK1 PPARG PPARG PRKAA2 PRKAA2 G6PC G6PC PPP2R5C PPP2R5C ADRA1A ADRA1A CREB3L3 CREB3L3 LEP LEP IGF1R IGF1R CAMKK2 CAMKK2 EEF2 EEF2 PPP2CA PPP2CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SREBF1Sterol regulatory element binding transcription factor 1. (1047 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (774 aa)
LIPELipase E, hormone sensitive type. (929 aa)
RHEBRas homolog, mTORC1 binding. (183 aa)
FOXO1Forkhead box O1. (539 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
IGF1Insulin like growth factor 1. (208 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
SIRT1Sirtuin 1. (731 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
AKT1S1AKT1 substrate 1. (276 aa)
MLYCDMalonyl-CoA decarboxylase. (493 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (275 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (442 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
EIF4EBP1Uncharacterized protein. (118 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (595 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (330 aa)
CAB39LCalcium binding protein 39 like. (359 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. (522 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (568 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CAB39Calcium binding protein 39. (341 aa)
IRS2Insulin receptor substrate 2. (904 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (328 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PPP2R2CProtein phosphatase 2 regulatory subunit Bgamma. (282 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PFKFB4Uncharacterized protein. (155 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
STRADASTE20 related adaptor alpha. (419 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (766 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
CRTC2CREB regulated transcription coactivator 2. (699 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (293 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
FASNFatty acid synthase. (2477 aa)
TSC1TSC complex subunit 1. (1164 aa)
CREB3cAMP responsive element binding protein 3. (370 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
RAB14RAB14, member RAS oncogene family. (215 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (452 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
SCDStearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
CCND1Cyclin D1. (156 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
RAB2ARAB2A, member RAS oncogene family. (211 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
LEPRLeptin receptor. (1169 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1098 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (503 aa)
TSC2TSC complex subunit 2. (1805 aa)
LOC108520497PFK domain-containing protein. (218 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
FOXO3Forkhead box O3. (672 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
ACACBAcetyl-CoA carboxylase beta. (2458 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
ADIPOR2Adiponectin receptor 2. (337 aa)
IRS4Insulin receptor substrate 4. (1247 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1044 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (298 aa)
PRKAA2Non-specific serine/threonine protein kinase. (539 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (571 aa)
ADRA1AAdrenoceptor alpha 1A. (455 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (483 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
EEF2Eukaryotic translation elongation factor 2. (861 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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