STRINGSTRING
CAT CAT PRKAG3 PRKAG3 PIK3R1 PIK3R1 PIK3R3 PIK3R3 ATG5 ATG5 CREB3L2 CREB3L2 ADCY6 ADCY6 MTOR MTOR ATF6B ATF6B RHEB RHEB FOXO1 FOXO1 STK11 STK11 IGF1 IGF1 SESN2 SESN2 ATG101 ATG101 PRKAG1 PRKAG1 SIRT1 SIRT1 PRKAB2 PRKAB2 AKT1S1 AKT1S1 ADIPOQ ADIPOQ CREB3L1 CREB3L1 EIF4EBP1 EIF4EBP1 NFKB1 NFKB1 IRS1 IRS1 SESN3 SESN3 INS INS ADCY7 ADCY7 IRS2 IRS2 PPARGC1A PPARGC1A ATF4 ATF4 PIK3CA PIK3CA RELA RELA PRKAB1 PRKAB1 ADIPOR1 ADIPOR1 ADCY9 ADCY9 ADCY3 ADCY3 HRAS HRAS CAMK4 CAMK4 TSC1 TSC1 ADCY8 ADCY8 CREB3 CREB3 RB1CC1 RB1CC1 ADCY2 ADCY2 EHMT1 EHMT1 PRKAA1 PRKAA1 KRAS KRAS TP53 TP53 SOD2 SOD2 EIF4E EIF4E EIF4E1B EIF4E1B CREB5 CREB5 EHMT2 EHMT2 TSC2 TSC2 CREB1 CREB1 AKT2 AKT2 ADCY5 ADCY5 AKT3 AKT3 FOXO3 FOXO3 PRKACB PRKACB PIK3CD PIK3CD ADCY1 ADCY1 BAX BAX KL KL ADIPOR2 ADIPOR2 IRS4 IRS4 ULK1 ULK1 PPARG PPARG PRKAA2 PRKAA2 NRAS NRAS CREB3L3 CREB3L3 IGF1R IGF1R CAMKK2 CAMKK2 ATG13 ATG13 EIF4E2 EIF4E2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1169 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
RHEBRas homolog, mTORC1 binding. (183 aa)
FOXO1Forkhead box O1. (539 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
IGF1Insulin like growth factor 1. (208 aa)
SESN2Sestrin 2. (450 aa)
ATG101Autophagy related 101. (218 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
SIRT1Sirtuin 1. (731 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
AKT1S1AKT1 substrate 1. (276 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (275 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (442 aa)
EIF4EBP1Uncharacterized protein. (118 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
SESN3Sestrin 3. (492 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
IRS2Insulin receptor substrate 2. (904 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
ATF4Activating transcription factor 4. (351 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
RELAUncharacterized protein. (282 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (472 aa)
TSC1TSC complex subunit 1. (1164 aa)
ADCY8Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (657 aa)
CREB3cAMP responsive element binding protein 3. (370 aa)
RB1CC1RB1 inducible coiled-coil 1. (1572 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
EHMT1Euchromatic histone lysine methyltransferase 1. (1281 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (232 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (240 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (503 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1266 aa)
TSC2TSC complex subunit 2. (1805 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
FOXO3Forkhead box O3. (672 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
KLKlotho. (951 aa)
ADIPOR2Adiponectin receptor 2. (337 aa)
IRS4Insulin receptor substrate 4. (1247 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1044 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (298 aa)
PRKAA2Non-specific serine/threonine protein kinase. (539 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (483 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (244 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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