STRINGSTRING
CAT CAT PRKAG3 PRKAG3 PIK3R1 PIK3R1 HSPA1L HSPA1L PIK3R3 PIK3R3 ATG5 ATG5 ADCY6 ADCY6 MTOR MTOR FOXO1 FOXO1 CLPB CLPB IGF1 IGF1 CRYAB CRYAB PRKAG1 PRKAG1 FOXA2 FOXA2 SIRT1 SIRT1 PRKAB2 PRKAB2 AKT1S1 AKT1S1 SOD1 SOD1 IRS1 IRS1 INS INS LOC108527145 LOC108527145 ADCY7 ADCY7 IRS2 IRS2 PIK3CA PIK3CA PRKAB1 PRKAB1 ADCY9 ADCY9 HDAC1 HDAC1 ADCY3 ADCY3 HRAS HRAS ADCY8 ADCY8 HDAC2 HDAC2 ADCY2 ADCY2 PRKAA1 PRKAA1 KRAS KRAS SOD2 SOD2 AKT2 AKT2 ADCY5 ADCY5 AKT3 AKT3 FOXO3 FOXO3 PRKACB PRKACB PIK3CD PIK3CD ADCY1 ADCY1 IRS4 IRS4 PRKAA2 PRKAA2 NRAS NRAS IGF1R IGF1R EIF4EBP2 EIF4EBP2 HSPA2 HSPA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1169 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
FOXO1Forkhead box O1. (539 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (707 aa)
IGF1Insulin like growth factor 1. (208 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
FOXA2Forkhead box A2. (463 aa)
SIRT1Sirtuin 1. (731 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
AKT1S1AKT1 substrate 1. (276 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LOC108527145Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (469 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
IRS2Insulin receptor substrate 2. (904 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ADCY8Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (657 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (232 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
FOXO3Forkhead box O3. (672 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
IRS4Insulin receptor substrate 4. (1247 aa)
PRKAA2Non-specific serine/threonine protein kinase. (539 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (120 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (619 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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