STRINGSTRING
IGFBP3 IGFBP3 SERPINE1 SERPINE1 BTRC BTRC MAPK3 MAPK3 CALML3 CALML3 RBBP4 RBBP4 PIK3R1 PIK3R1 PIK3R3 PIK3R3 PPP3CA PPP3CA LOC108512004 LOC108512004 PPP3CB PPP3CB RBL2 RBL2 E2F5 E2F5 TGFB2 TGFB2 HIPK4 HIPK4 LOC108543093 LOC108543093 MTOR MTOR ETS1 ETS1 CALML4 CALML4 SLC25A31 SLC25A31 RHEB RHEB ZFP36L2 ZFP36L2 FOXO1 FOXO1 CXCL8 CXCL8 TGFB1 TGFB1 NFATC4 NFATC4 CALM1 CALM1 TRAF3IP2 TRAF3IP2 PPID PPID VDAC1 VDAC1 HIPK3 HIPK3 SIRT1 SIRT1 NFATC2 NFATC2 NFATC3 NFATC3 PPP1CB PPP1CB RAF1 RAF1 PPP3CC PPP3CC EIF4EBP1 EIF4EBP1 CCNB3 CCNB3 SMAD2 SMAD2 NFKB1 NFKB1 PPP1CC PPP1CC MAP2K1 MAP2K1 CCNB1 CCNB1 SLC25A4 SLC25A4 VDAC2 VDAC2 MAP2K3 MAP2K3 PIK3CA PIK3CA LOC108525123 LOC108525123 RELA RELA RAD50 RAD50 CDK4 CDK4 RB1 RB1 RRAS2 RRAS2 RASSF5 RASSF5 CCNB2 CCNB2 ATM ATM MAP2K6 MAP2K6 CACNA1D CACNA1D HRAS HRAS GADD45B GADD45B ITPR2 ITPR2 RBL1 RBL1 TGFBR2 TGFBR2 ITPR1 ITPR1 RAD9B RAD9B HLA-F HLA-F TSC1 TSC1 CAPN2 CAPN2 TRPM7 TRPM7 CCNA1 CCNA1 RAD1 RAD1 GADD45G GADD45G HLA-E HLA-E CCND1 CCND1 NBN NBN LIN37 LIN37 SLC25A6 SLC25A6 MAPK1 MAPK1 TGFB3 TGFB3 KRAS KRAS MCU MCU ATR ATR HUS1 HUS1 NFATC1 NFATC1 MAPK14 MAPK14 CCND3 CCND3 VDAC3 VDAC3 MRAS MRAS TP53 TP53 E2F2 E2F2 TSC2 TSC2 FOXM1 FOXM1 LIN52 LIN52 HIPK2 HIPK2 MAPK13 MAPK13 CALM3 CALM3 SQSTM1 SQSTM1 MYC MYC ZFP36L1 ZFP36L1 E2F4 E2F4 GATA4 GATA4 AKT2 AKT2 CCNE2 CCNE2 TGFBR1 TGFBR1 AKT3 AKT3 MAPKAPK2 MAPKAPK2 MAPK11 MAPK11 FOXO3 FOXO3 PTEN PTEN PIK3CD PIK3CD CAPN1 CAPN1 IL1A IL1A CCNA2 CCNA2 TRPV4 TRPV4 GADD45A GADD45A LOC108528436 LOC108528436 NRAS NRAS CCND2 CCND2 LIN54 LIN54 LIN9 LIN9 E2F3 E2F3 PPP1CA PPP1CA IL6 IL6 ITPR3 ITPR3 CDK1 CDK1 RRAS RRAS CDK6 CDK6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IGFBP3Insulin like growth factor binding protein 3. (291 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (429 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
RBBP4WD_REPEATS_REGION domain-containing protein. (419 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PPP3CASerine/threonine-protein phosphatase. (310 aa)
LOC108512004Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
RBL2RB transcriptional corepressor like 2. (1127 aa)
E2F5E2F transcription factor 5. (345 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HIPK4Homeodomain interacting protein kinase 4. (615 aa)
LOC108543093Ig-like domain-containing protein; Belongs to the MHC class I family. (378 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
CALML4Calmodulin like 4. (192 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (314 aa)
RHEBRas homolog, mTORC1 binding. (183 aa)
ZFP36L2ZFP36 ring finger protein like 2. (499 aa)
FOXO1Forkhead box O1. (539 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NFATC4Nuclear factor of activated T cells 4. (909 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
TRAF3IP2TRAF3 interacting protein 2. (563 aa)
PPIDPeptidylprolyl isomerase D. (370 aa)
VDAC1Voltage dependent anion channel 1. (299 aa)
HIPK3Homeodomain interacting protein kinase 3. (1215 aa)
SIRT1Sirtuin 1. (731 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
NFATC3Nuclear factor of activated T cells 3. (1056 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
RAF1Uncharacterized protein. (668 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
EIF4EBP1Uncharacterized protein. (118 aa)
CCNB3Uncharacterized protein; Belongs to the cyclin family. (223 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (433 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
VDAC2Voltage dependent anion channel 2. (308 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
LOC108525123Uncharacterized protein. (679 aa)
RELAUncharacterized protein. (282 aa)
RAD50Zinc-hook domain-containing protein. (1281 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RB1RB transcriptional corepressor 1. (815 aa)
RRAS2RAS related 2. (185 aa)
RASSF5Ras association domain family member 5. (418 aa)
CCNB2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (398 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3026 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2180 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2637 aa)
RBL1RB transcriptional corepressor like 1. (1069 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (404 aa)
HLA-FMajor histocompatibility complex, class I, F; Belongs to the MHC class I family. (369 aa)
TSC1TSC complex subunit 1. (1164 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (726 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1746 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
RAD1Uncharacterized protein. (280 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (359 aa)
CCND1Cyclin D1. (156 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa)
LIN37Lin-37 DREAM MuvB core complex component. (246 aa)
SLC25A6Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MCUMitochondrial calcium uniporter. (351 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2578 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
NFATC1Nuclear factor of activated T cells 1. (989 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (286 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
E2F2E2F transcription factor 2. (437 aa)
TSC2TSC complex subunit 2. (1805 aa)
FOXM1Forkhead box M1. (654 aa)
LIN52Lin-52 DREAM MuvB core complex component. (116 aa)
HIPK2Homeodomain interacting protein kinase 2. (1209 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (163 aa)
SQSTM1Sequestosome 1. (451 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
ZFP36L1Uncharacterized protein. (327 aa)
E2F4E2F transcription factor 4. (415 aa)
GATA4GATA binding protein 4. (432 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (403 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
MAPKAPK2MAPK activated protein kinase 2. (392 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
FOXO3Forkhead box O3. (672 aa)
PTENUncharacterized protein. (555 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CAPN1Calpain 1; Belongs to the peptidase C2 family. (736 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
LOC108528436Ig-like domain-containing protein; Belongs to the MHC class I family. (394 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CCND2Uncharacterized protein; Belongs to the cyclin family. (244 aa)
LIN54Lin-54 DREAM MuvB core complex component. (749 aa)
LIN9Lin-9 DREAM MuvB core complex component. (360 aa)
E2F3E2F transcription factor 3. (465 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
IL6Interleukin 6. (214 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
RRASRAS related. (218 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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