STRINGSTRING
MAPK3 MAPK3 PLA2G4B PLA2G4B CALML3 CALML3 PRKCG PRKCG PLA2G4F PLA2G4F ENSRBIP00000002156 ENSRBIP00000002156 GNA11 GNA11 ADCY6 ADCY6 CALML4 CALML4 PPP1R12C PPP1R12C CACNA1S CACNA1S PLA2G1B PLA2G1B PLCB1 PLCB1 NPR2 NPR2 MYLK3 MYLK3 ARAF ARAF MYL9 MYL9 CALM1 CALM1 GNA13 GNA13 ROCK1 ROCK1 PLA2G2C PLA2G2C PPP1CB PPP1CB RAF1 RAF1 MYL6 MYL6 LOC108515802 LOC108515802 PLA2G5 PLA2G5 EDNRA EDNRA PLA2G12B PLA2G12B PLA2G4C PLA2G4C KCNMB1 KCNMB1 PPP1CC PPP1CC MAP2K1 MAP2K1 PLA2G4A PLA2G4A ADCY7 ADCY7 AVPR1A AVPR1A NPPC NPPC AVPR1B AVPR1B RAMP3 RAMP3 GNA12 GNA12 PRKCA PRKCA MYH14 MYH14 PLA2G12A PLA2G12A ADCY9 ADCY9 CACNA1D CACNA1D BRAF BRAF ADCY3 ADCY3 MYH10 MYH10 CALD1 CALD1 ITPR2 ITPR2 PRKCD PRKCD MYLK MYLK ITPR1 ITPR1 ADCY8 ADCY8 MYLK2 MYLK2 ADCY2 ADCY2 ADORA2A ADORA2A ARHGEF11 ARHGEF11 ARHGEF12 ARHGEF12 ACTG2 ACTG2 PLA2G4E PLA2G4E MYLK4 MYLK4 MAPK1 MAPK1 EDN1 EDN1 GUCY1A1 GUCY1A1 CALCB CALCB CALCRL CALCRL LOC108535621 LOC108535621 PLA2G2D PLA2G2D PRKCQ PRKCQ EDN2 EDN2 PLA2G2F PLA2G2F PLA2G3 PLA2G3 MRVI1 MRVI1 CALM3 CALM3 NPR1 NPR1 KCNMB2 KCNMB2 CALCA CALCA PLA2G4D PLA2G4D RAMP2 RAMP2 ADCY5 ADCY5 ADORA2B ADORA2B PRKACB PRKACB CACNA1F CACNA1F ADCY1 ADCY1 AGTR1 AGTR1 LOC108525089 LOC108525089 GNAS GNAS GNAQ GNAQ AVP AVP PPP1R14A PPP1R14A PLCB2 PLCB2 MYH9 MYH9 KCNU1 KCNU1 PLCB4 PLCB4 PLA2G6 PLA2G6 MYH11 MYH11 ADRA1A ADRA1A PRKCE PRKCE PPP1CA PPP1CA ADM ADM LOC108541626 LOC108541626 ITPR3 ITPR3 RHOA RHOA PLA2G2E PLA2G2E PRKCH PRKCH ROCK2 ROCK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
PLA2G4BPhospholipase A2. (781 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PRKCGProtein kinase C. (726 aa)
PLA2G4FPhospholipase A2. (827 aa)
ENSRBIP00000002156Uncharacterized protein. (366 aa)
GNA11G protein subunit alpha 11. (354 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1169 aa)
CALML4Calmodulin like 4. (192 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (811 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
PLA2G1BPhospholipase A(2). (148 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1079 aa)
NPR2Guanylate cyclase. (1047 aa)
MYLK3Myosin light chain kinase 3. (818 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MYL9Myosin light chain 9. (172 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
GNA13G protein subunit alpha 13. (353 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1341 aa)
PLA2G2CPhospholipase A(2). (151 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
RAF1Uncharacterized protein. (668 aa)
MYL6Uncharacterized protein. (226 aa)
LOC108515802Uncharacterized protein. (139 aa)
PLA2G5Phospholipase A(2). (138 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (426 aa)
PLA2G12BPhospholipase A2 group XIIB. (195 aa)
PLA2G4CPhospholipase A2 group IVC. (551 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PLA2G4APhospholipase A2. (738 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
NPPCNatriuretic peptide C. (126 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
RAMP3Receptor activity modifying protein 3. (151 aa)
GNA12G protein subunit alpha 12. (322 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (604 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1869 aa)
PLA2G12APhospholipase A2 group XIIA. (208 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2180 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (753 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
CALD1Caldesmon 1. (778 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2637 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
MYLKMyosin light chain kinase. (1656 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
ADCY8Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (657 aa)
MYLK2Myosin light chain kinase 2. (603 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1561 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1536 aa)
ACTG2Actin gamma 2, smooth muscle. (376 aa)
PLA2G4EPhospholipase A2. (869 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (388 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
EDN1Endothelin 1. (211 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
CALCBCalcitonin related polypeptide beta. (138 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (461 aa)
LOC108535621Uncharacterized protein; Belongs to the cytochrome P450 family. (519 aa)
PLA2G2DPhospholipase A(2). (161 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
EDN2Endothelin 2. (178 aa)
PLA2G2FPhospholipase A(2). (199 aa)
PLA2G3Phospholipase A2 group III. (508 aa)
MRVI1Murine retrovirus integration site 1 homolog. (911 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (163 aa)
NPR1Guanylate cyclase. (1061 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (235 aa)
CALCACalcitonin related polypeptide alpha. (144 aa)
PLA2G4DPhospholipase A2. (816 aa)
RAMP2Receptor activity modifying protein 2. (175 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (394 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1818 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
LOC108525089END domain-containing protein. (114 aa)
GNASGNAS complex locus. (1041 aa)
GNAQG protein subunit alpha q. (359 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
PPP1R14AProtein phosphatase 1 regulatory inhibitor subunit 14A. (147 aa)
PLCB2Phosphoinositide phospholipase C. (991 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1962 aa)
KCNU1Potassium calcium-activated channel subfamily U member 1. (1149 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1199 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2018 aa)
ADRA1AAdrenoceptor alpha 1A. (455 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
ADMAdrenomedullin. (185 aa)
LOC108541626Uncharacterized protein. (246 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
RHOAUncharacterized protein. (104 aa)
PLA2G2EPhospholipase A(2). (142 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1387 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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