STRINGSTRING
LOC108517065 LOC108517065 MAPK3 MAPK3 SMURF2 SMURF2 INHBC INHBC E2F5 E2F5 GDF6 GDF6 TGFB2 TGFB2 GREM2 GREM2 NOG NOG LOC108544295 LOC108544295 DCN DCN NBL1 NBL1 TGIF1 TGIF1 HAMP HAMP LOC108517059 LOC108517059 CHRD CHRD TGFB1 TGFB1 ACVR1 ACVR1 PPP2R1B PPP2R1B THSD4 THSD4 INHBB INHBB PPP2R1A PPP2R1A ROCK1 ROCK1 TNF TNF SMAD2 SMAD2 BMPR2 BMPR2 TFDP1 TFDP1 CUL1 CUL1 BMP6 BMP6 GDF7 GDF7 HJV HJV BMPR1A BMPR1A ZFYVE9 ZFYVE9 SMAD1 SMAD1 GDF5 GDF5 SMAD4 SMAD4 ENSRBIP00000020047 ENSRBIP00000020047 INHBA INHBA BAMBI BAMBI LTBP1 LTBP1 RBL1 RBL1 FST FST TGFBR2 TGFBR2 MAPK1 MAPK1 TGFB3 TGFB3 ACVR1B ACVR1B BMP5 BMP5 INHBE INHBE RGMA RGMA SMAD7 SMAD7 ACVR2B ACVR2B NODAL NODAL ID1 ID1 SMAD5 SMAD5 RGMB RGMB CREBBP CREBBP ID3 ID3 ZFYVE16 ZFYVE16 IFNG IFNG FMOD FMOD MYC MYC EP300 EP300 E2F4 E2F4 TGFBR1 TGFBR1 BMPR1B BMPR1B ACVR1C ACVR1C ACVR2A ACVR2A NEO1 NEO1 BMP4 BMP4 PITX2 PITX2 LEFTY1 LEFTY1 SMAD9 SMAD9 RBX1 RBX1 THBS1 THBS1 FBN1 FBN1 AMHR2 AMHR2 RHOA RHOA TGIF2 TGIF2 BMP7 BMP7 ID2 ID2 PPP2CA PPP2CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108517065TGF_BETA_2 domain-containing protein. (261 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
SMURF2SMAD specific E3 ubiquitin protein ligase 2. (719 aa)
INHBCInhibin subunit beta C. (352 aa)
E2F5E2F transcription factor 5. (345 aa)
GDF6Growth differentiation factor 6. (455 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GREM2Gremlin. (168 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (231 aa)
LOC108544295Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
NBL1NBL1, DAN family BMP antagonist. (193 aa)
TGIF1TGFB induced factor homeobox 1. (367 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
LOC108517059TGF_BETA_2 domain-containing protein. (402 aa)
CHRDChordin. (906 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
THSD4Thrombospondin type 1 domain containing 4. (658 aa)
INHBBInhibin subunit beta B. (407 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1341 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TFDP1Transcription factor. (410 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
BMP6Bone morphogenetic protein 6. (440 aa)
GDF7Growth differentiation factor 7. (432 aa)
HJVHemojuvelin BMP co-receptor. (425 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1384 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
GDF5Growth differentiation factor 5. (499 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ENSRBIP00000020047Uncharacterized protein; Belongs to the SKP1 family. (162 aa)
INHBAInhibin subunit beta A. (426 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1706 aa)
RBL1RB transcriptional corepressor like 1. (1069 aa)
FSTFollistatin. (333 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
BMP5TGF_BETA_2 domain-containing protein. (154 aa)
INHBEInhibin subunit beta E. (351 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
SMAD7Mothers against decapentaplegic homolog. (431 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
NODALNodal growth differentiation factor. (347 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (511 aa)
CREBBPCREB binding protein. (2422 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1506 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (159 aa)
FMODFibromodulin. (376 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
EP300E1A binding protein p300. (2296 aa)
E2F4E2F transcription factor 4. (415 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (413 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
NEO1Neogenin 1. (1416 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
PITX2Homeobox protein. (389 aa)
LEFTY1Left-right determination factor. (366 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
RBX1Ring-box 1. (108 aa)
THBS1Thrombospondin 1. (1170 aa)
FBN1Fibrillin 1. (2871 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (573 aa)
RHOAUncharacterized protein. (104 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.