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ROBO3 ROBO3 PAK5 PAK5 LRRC4 LRRC4 PLXNC1 PLXNC1 MAPK3 MAPK3 LOC108533552 LOC108533552 LRRC4C LRRC4C CFL2 CFL2 PIK3R1 PIK3R1 RND1 RND1 SRC SRC PIK3R3 PIK3R3 EPHB4 EPHB4 PPP3CA PPP3CA PPP3CB PPP3CB CFL1 CFL1 EFNA4 EFNA4 SEMA3G SEMA3G PAK6 PAK6 EFNB1 EFNB1 SEMA4F SEMA4F TRPC5 TRPC5 EFNA3 EFNA3 PAK4 PAK4 EPHA6 EPHA6 EFNB3 EFNB3 TRPC1 TRPC1 PARD3 PARD3 SEMA4G SEMA4G FYN FYN PLXNB3 PLXNB3 SEMA4B SEMA4B ROBO1 ROBO1 ABL1 ABL1 ABLIM3 ABLIM3 CAMK2D CAMK2D NFATC4 NFATC4 MYL9 MYL9 LIMK1 LIMK1 ROCK1 ROCK1 NFATC2 NFATC2 EPHB3 EPHB3 NFATC3 NFATC3 RAF1 RAF1 PPP3CC PPP3CC CXCR4 CXCR4 SHH SHH PLXNB2 PLXNB2 PTCH1 PTCH1 SRGAP2 SRGAP2 BMPR2 BMPR2 NCK1 NCK1 RHOD RHOD PLCG2 PLCG2 GDF7 GDF7 DPYSL5 DPYSL5 SLIT2 SLIT2 SLIT3 SLIT3 SEMA3B SEMA3B PIK3CA PIK3CA LOC108522676 LOC108522676 SEMA4C SEMA4C EPHA2 EPHA2 PARD6B PARD6B SEMA7A SEMA7A SEMA5A SEMA5A EPHA4 EPHA4 PRKCA PRKCA ILK ILK PAK1 PAK1 MYL12B MYL12B SEMA4D SEMA4D PAK2 PAK2 ITGB1 ITGB1 FES FES HRAS HRAS PLXNA3 PLXNA3 NRP1 NRP1 SRGAP3 SRGAP3 PLXNA2 PLXNA2 EFNA5 EFNA5 SRGAP1 SRGAP1 GSK3B GSK3B CDK5 CDK5 WNT5B WNT5B LIMK2 LIMK2 ARHGEF12 ARHGEF12 PLXNA4 PLXNA4 SSH2 SSH2 L1CAM L1CAM SEMA3D SEMA3D MAPK1 MAPK1 SEMA4A SEMA4A KRAS KRAS RGMA RGMA SEMA3C SEMA3C DCC DCC TRPC6 TRPC6 NTN1 NTN1 PARD6G PARD6G SEMA3F SEMA3F DPYSL2 DPYSL2 BOC BOC GNAI2 GNAI2 SSH1 SSH1 PDK1 PDK1 RGS3 RGS3 UNC5D UNC5D NTN4 NTN4 TRPC3 TRPC3 EPHA1 EPHA1 SLIT1 SLIT1 EPHA7 EPHA7 FZD3 FZD3 CXCL12 CXCL12 MET MET MYL5 MYL5 CAMK2A CAMK2A UNC5A UNC5A NCK2 NCK2 PIK3CD PIK3CD BMPR1B BMPR1B PLXNB1 PLXNB1 SEMA6C SEMA6C EPHA8 EPHA8 UNC5C UNC5C CDC42 CDC42 SEMA3A SEMA3A NTN3 NTN3 NEO1 NEO1 PLCG1 PLCG1 NRAS NRAS SSH3 SSH3 RAC2 RAC2 GNAI3 GNAI3 EPHA5 EPHA5 SEMA5B SEMA5B TRPC4 TRPC4 WNT5A WNT5A SEMA6A SEMA6A SMO SMO PARD6A PARD6A EFNA1 EFNA1 RHOA RHOA SEMA6D SEMA6D RRAS RRAS EPHB6 EPHB6 ROCK2 ROCK2 BMP7 BMP7 EPHB1 EPHB1 EPHB2 EPHB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ROBO3Roundabout guidance receptor 3. (1384 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
LRRC4Leucine rich repeat containing 4. (633 aa)
PLXNC1Plexin C1. (1568 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
LOC108533552Uncharacterized protein. (177 aa)
LRRC4CLeucine rich repeat containing 4C. (640 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RND1Rho family GTPase 1. (232 aa)
SRCTyrosine-protein kinase. (627 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
EPHB4EPH receptor B4. (987 aa)
PPP3CASerine/threonine-protein phosphatase. (310 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (189 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (201 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (782 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (959 aa)
EFNA3Ephrin A3; Belongs to the ephrin family. (238 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
EPHA6EPH receptor A6. (1130 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (724 aa)
PARD3Par-3 family cell polarity regulator. (1356 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (837 aa)
FYNTyrosine-protein kinase. (537 aa)
PLXNB3Plexin B3. (1909 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (845 aa)
ROBO1Roundabout guidance receptor 1. (1621 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
ABLIM3Actin binding LIM protein family member 3. (684 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
NFATC4Nuclear factor of activated T cells 4. (909 aa)
MYL9Myosin light chain 9. (172 aa)
LIMK1LIM domain kinase 1. (677 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1341 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
EPHB3EPH receptor B3. (1008 aa)
NFATC3Nuclear factor of activated T cells 3. (1056 aa)
RAF1Uncharacterized protein. (668 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (415 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
PLXNB2Plexin B2. (1591 aa)
PTCH1Patched 1. (1455 aa)
SRGAP2Uncharacterized protein. (1071 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
NCK1NCK adaptor protein 1. (371 aa)
RHODRas homolog family member D. (210 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
GDF7Growth differentiation factor 7. (432 aa)
DPYSL5Dihydropyrimidinase like 5. (565 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
SLIT3Slit guidance ligand 3. (1530 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (754 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
LOC108522676Protein kinase domain-containing protein. (299 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
EPHA2EPH receptor A2. (1036 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (668 aa)
SEMA5ASemaphorin 5A. (1035 aa)
EPHA4EPH receptor A4. (978 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (604 aa)
ILKIntegrin linked kinase. (482 aa)
PAK1Non-specific serine/threonine protein kinase. (555 aa)
MYL12BUncharacterized protein. (172 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
PAK2Non-specific serine/threonine protein kinase. (539 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (937 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PLXNA3Plexin A3. (1876 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
SRGAP3SLIT-ROBO Rho GTPase activating protein 3. (1099 aa)
PLXNA2Plexin A2. (1894 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
SRGAP1SLIT-ROBO Rho GTPase activating protein 1. (1041 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
LIMK2LIM domain kinase 2. (639 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1536 aa)
PLXNA4Plexin A4. (1894 aa)
SSH2Slingshot protein phosphatase 2. (1450 aa)
L1CAML1 cell adhesion molecule. (1257 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (673 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (760 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
DCCDCC netrin 1 receptor. (762 aa)
TRPC6Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (827 aa)
NTN1Netrin 1. (604 aa)
PARD6GPar-6 family cell polarity regulator gamma. (376 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
DPYSL2Dihydropyrimidinase like 2. (677 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1115 aa)
GNAI2G protein subunit alpha i2. (355 aa)
SSH1Slingshot protein phosphatase 1. (1048 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
RGS3Regulator of G protein signaling 3. (916 aa)
UNC5DUnc-5 netrin receptor D. (958 aa)
NTN4Netrin 4. (628 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa)
EPHA1EPH receptor A1. (963 aa)
SLIT1Slit guidance ligand 1. (1533 aa)
EPHA7EPH receptor A7. (985 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1383 aa)
MYL5Myosin light chain 5. (173 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
UNC5AUnc-5 netrin receptor A. (899 aa)
NCK2Cytoplasmic protein. (380 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PLXNB1Plexin B1. (2130 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (961 aa)
EPHA8EPH receptor A8. (987 aa)
UNC5CUnc-5 netrin receptor C. (931 aa)
CDC42Uncharacterized protein. (191 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (774 aa)
NTN3Netrin 3. (606 aa)
NEO1Neogenin 1. (1416 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SSH3Slingshot protein phosphatase 3. (657 aa)
RAC2Rac family small GTPase 2. (192 aa)
GNAI3G protein subunit alpha i3. (354 aa)
EPHA5EPH receptor A5. (1038 aa)
SEMA5BSemaphorin 5B. (1193 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (156 aa)
RHOAUncharacterized protein. (104 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1086 aa)
RRASRAS related. (218 aa)
EPHB6EPH receptor B6. (1018 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1387 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
EPHB1EPH receptor B1. (984 aa)
EPHB2EPH receptor B2. (1082 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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