STRINGSTRING
SERPINE1 SERPINE1 APLNR APLNR MAPK3 MAPK3 CALML3 CALML3 PRKAG3 PRKAG3 EGR1 EGR1 SLC8A1 SLC8A1 ADCY6 ADCY6 MTOR MTOR SLC9A1 SLC9A1 CALML4 CALML4 LIPE LIPE GNB4 GNB4 PLCB1 PLCB1 SLC8A3 SLC8A3 ENSRBIP00000007423 ENSRBIP00000007423 GABARAP GABARAP MYLK3 MYLK3 RYR2 RYR2 CALM1 CALM1 PRKAG1 PRKAG1 GNA13 GNA13 GNG7 GNG7 MYL4 MYL4 GNG13 GNG13 LOC108513197 LOC108513197 PRKAB2 PRKAB2 RAF1 RAF1 PIK3R4 PIK3R4 MEF2A MEF2A SMAD2 SMAD2 APLN APLN SLC8A2 SLC8A2 JAG1 JAG1 PIK3R6 PIK3R6 MAP2K1 MAP2K1 TFAM TFAM ADCY7 ADCY7 PIK3C3 PIK3C3 PPARGC1A PPARGC1A GNB3 GNB3 HDAC5 HDAC5 GNG4 GNG4 MYL2 MYL2 GNG5 GNG5 SMAD4 SMAD4 GNG11 GNG11 RRAS2 RRAS2 PRKAB1 PRKAB1 ADCY9 ADCY9 BECN1 BECN1 HDAC4 HDAC4 ADCY3 ADCY3 HRAS HRAS ADCY10 ADCY10 CAMK4 CAMK4 MYL3 MYL3 GNG2 GNG2 ITPR2 ITPR2 MYLK MYLK ITPR1 ITPR1 ADCY8 ADCY8 MYLK2 MYLK2 ADCY2 ADCY2 SPHK2 SPHK2 SPHK1 SPHK1 PRKAA1 PRKAA1 MYLK4 MYLK4 SPP1 SPP1 CCND1 CCND1 GNG3 GNG3 MAPK1 MAPK1 NOS1 NOS1 KRAS KRAS PLAT PLAT GABARAPL1 GABARAPL1 KLF2 KLF2 MRAS MRAS GNAI2 GNAI2 GNG12 GNG12 GABARAPL2 GABARAPL2 GNB1 GNB1 GNG8 GNG8 CALM3 CALM3 AKT2 AKT2 NOS3 NOS3 TGFBR1 TGFBR1 ADCY5 ADCY5 AKT3 AKT3 PRKACB PRKACB GNB5 GNB5 ADCY1 ADCY1 AGTR1 AGTR1 GNAQ GNAQ UCP1 UCP1 PLIN1 PLIN1 PLCB2 PLCB2 PRKAA2 PRKAA2 PLCB4 PLCB4 RYR1 RYR1 NRAS NRAS RYR3 RYR3 GNAI3 GNAI3 PRKCE PRKCE PIK3CG PIK3CG NOS2 NOS2 ITPR3 ITPR3 RRAS RRAS PIK3R5 PIK3R5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SERPINE1Serpin family E member 1; Belongs to the serpin family. (429 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1169 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
CALML4Calmodulin like 4. (192 aa)
LIPELipase E, hormone sensitive type. (929 aa)
GNB4G protein subunit beta 4. (340 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1079 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
ENSRBIP00000007423Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
GABARAPUncharacterized protein. (119 aa)
MYLK3Myosin light chain kinase 3. (818 aa)
RYR2Ryanodine receptor 2. (4866 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
GNA13G protein subunit alpha 13. (353 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
MYL4Myosin light chain 4. (195 aa)
GNG13G protein subunit gamma 13. (67 aa)
LOC10851319740S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
RAF1Uncharacterized protein. (668 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
MEF2AMyocyte enhancer factor 2A. (511 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
APLNApelin. (77 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (907 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
TFAMTranscription factor A, mitochondrial. (251 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (911 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
GNB3G protein subunit beta 3. (340 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1123 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
MYL2Myosin light chain 2. (166 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
RRAS2RAS related 2. (185 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
BECN1Beclin 1. (450 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1112 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ADCY10Adenylate cyclase 10. (1609 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (472 aa)
MYL3Myosin light chain 3. (213 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (102 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2637 aa)
MYLKMyosin light chain kinase. (1656 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
ADCY8Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (657 aa)
MYLK2Myosin light chain kinase 2. (603 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
SPHK2Sphingosine kinase 2. (658 aa)
SPHK1Sphingosine kinase 1. (384 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (388 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
CCND1Cyclin D1. (156 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1333 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
GABARAPL1GABA type A receptor associated protein like 1. (146 aa)
KLF2Uncharacterized protein. (194 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
GNAI2G protein subunit alpha i2. (355 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GABARAPL2GABA type A receptor associated protein like 2. (124 aa)
GNB1G protein subunit beta 1. (340 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (163 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNB5G protein subunit beta 5. (403 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
GNAQG protein subunit alpha q. (359 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
PLIN1Perilipin; Belongs to the perilipin family. (513 aa)
PLCB2Phosphoinositide phospholipase C. (991 aa)
PRKAA2Non-specific serine/threonine protein kinase. (539 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1199 aa)
RYR1Ryanodine receptor 1. (4866 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RYR3Ryanodine receptor 3. (4831 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1126 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
RRASRAS related. (218 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (879 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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