STRINGSTRING
OCLN OCLN CLDN16 CLDN16 LOC108533552 LOC108533552 MAP3K1 MAP3K1 RUNX1 RUNX1 CLDN4 CLDN4 PRKAG3 PRKAG3 CLDN2 CLDN2 SRC SRC CLDN14 CLDN14 LOC108525726 LOC108525726 ACTB ACTB HCLS1 HCLS1 MAPK10 MAPK10 SYNPO SYNPO RAP1A RAP1A RAPGEF2 RAPGEF2 CGN CGN CRB3 CRB3 DLG1 DLG1 PARD3 PARD3 DLG2 DLG2 TUBAL3 TUBAL3 TJP2 TJP2 TJAP1 TJAP1 CLDN20 CLDN20 STK11 STK11 MAPK9 MAPK9 SLC9A3R1 SLC9A3R1 PCNA PCNA LLGL2 LLGL2 MICALL2 MICALL2 PPP2R1B PPP2R1B MYL9 MYL9 ACTR3B ACTR3B CLDN6 CLDN6 PPP2R2A PPP2R2A PRKAG1 PRKAG1 PPP2R1A PPP2R1A ROCK1 ROCK1 PRKAB2 PRKAB2 RAP2C RAP2C CLDN5 CLDN5 MYL6 MYL6 LOC108515802 LOC108515802 CLDN8 CLDN8 AMOTL2 AMOTL2 CLDN17 CLDN17 LLGL1 LLGL1 MPP5 MPP5 TJP3 TJP3 JAM3 JAM3 CLDN11 CLDN11 CD1C CD1C BVES BVES PPP2R2C PPP2R2C RDX RDX PARD6B PARD6B MYL2 MYL2 TIAM1 TIAM1 CDK4 CDK4 JAM2 JAM2 PRKAB1 PRKAB1 MYH14 MYH14 MARVELD3 MARVELD3 MYL12B MYL12B RAB8B RAB8B CACNA1D CACNA1D ITGB1 ITGB1 MYH10 MYH10 ACTR3 ACTR3 TUBA8 TUBA8 ARHGEF2 ARHGEF2 MAGI1 MAGI1 F11R F11R PRKAA1 PRKAA1 TJP1 TJP1 ACTN1 ACTN1 CCND1 CCND1 MPP4 MPP4 EZR EZR PPP2R2D PPP2R2D NEDD4L NEDD4L CFTR CFTR MARVELD2 MARVELD2 PARD6G PARD6G MAP3K5 MAP3K5 YBX3 YBX3 RAB8A RAB8A CLDN15 CLDN15 CD1E CD1E ERBB2 ERBB2 HSPA4 HSPA4 CLDN18 CLDN18 ACTR2 ACTR2 ARHGEF18 ARHGEF18 GATA4 GATA4 ACTN4 ACTN4 LOC108518420 LOC108518420 SYMPK SYMPK PRKACB PRKACB CLDN1 CLDN1 CLDN3 CLDN3 MAP2K7 MAP2K7 CD1B CD1B PPP2R2B PPP2R2B MSN MSN CDC42 CDC42 MYH9 MYH9 CLDN7 CLDN7 PRKAA2 PRKAA2 PRKCI PRKCI AMOTL1 AMOTL1 MYH11 MYH11 AMOT AMOT PRKCE PRKCE PATJ PATJ CD1D CD1D CLDN10 CLDN10 PARD6A PARD6A RHOA RHOA SCRIB SCRIB ROCK2 ROCK2 PPP2CA PPP2CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (304 aa)
LOC108533552Uncharacterized protein. (177 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1374 aa)
RUNX1RUNX family transcription factor 1. (264 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
SRCTyrosine-protein kinase. (627 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (239 aa)
LOC108525726Tubulin_C domain-containing protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (249 aa)
ACTBActin beta. (379 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (476 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
SYNPOSynaptopodin. (929 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1474 aa)
CGNMyosin_tail_1 domain-containing protein. (1210 aa)
CRB3Crumbs cell polarity complex component 3. (123 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (861 aa)
PARD3Par-3 family cell polarity regulator. (1356 aa)
DLG2Uncharacterized protein. (552 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
TJP2Uncharacterized protein; Belongs to the MAGUK family. (1246 aa)
TJAP1Tight junction associated protein 1. (550 aa)
CLDN20Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1020 aa)
MICALL2MICAL like 2. (862 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
MYL9Myosin light chain 9. (172 aa)
ACTR3BActin related protein 3B; Belongs to the actin family. (423 aa)
CLDN6Uncharacterized protein. (39 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1341 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
RAP2CRAP2C, member of RAS oncogene family. (99 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
MYL6Uncharacterized protein. (226 aa)
LOC108515802Uncharacterized protein. (139 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
AMOTL2Angiomotin like 2. (837 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1042 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (665 aa)
TJP3Tight junction protein 3; Belongs to the MAGUK family. (922 aa)
JAM3Junctional adhesion molecule 3. (355 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
CD1CCD1c molecule. (332 aa)
BVESBlood vessel epicardial substance. (360 aa)
PPP2R2CProtein phosphatase 2 regulatory subunit Bgamma. (282 aa)
RDXRadixin. (604 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
MYL2Myosin light chain 2. (166 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
JAM2Junctional adhesion molecule 2. (309 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1869 aa)
MARVELD3MARVEL domain containing 3. (410 aa)
MYL12BUncharacterized protein. (172 aa)
RAB8BRAB8B, member RAS oncogene family. (207 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2180 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (937 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (368 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1003 aa)
MAGI1Membrane associated guanylate kinase, WW and PDZ domain containing 1. (1160 aa)
F11RF11 receptor. (299 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1737 aa)
ACTN1Actinin alpha 1. (910 aa)
CCND1Cyclin D1. (156 aa)
MPP4Membrane palmitoylated protein 4; Belongs to the MAGUK family. (636 aa)
EZREzrin. (588 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1227 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
MARVELD2MARVEL domain containing 2. (559 aa)
PARD6GPar-6 family cell polarity regulator gamma. (376 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
YBX3Y-box binding protein 3. (371 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
CD1ECD1e molecule. (387 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
HSPA4Heat shock protein family A (Hsp70) member 4. (846 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
ARHGEF18Uncharacterized protein. (1173 aa)
GATA4GATA binding protein 4. (432 aa)
ACTN4Actinin alpha 4. (931 aa)
LOC108518420Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (307 aa)
SYMPKSymplekin. (1383 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CLDN3Claudin 3. (211 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (414 aa)
CD1BCD1b molecule. (333 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
MSNMoesin. (577 aa)
CDC42Uncharacterized protein. (191 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1962 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
PRKAA2Non-specific serine/threonine protein kinase. (539 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (581 aa)
AMOTL1Angiomotin like 1. (951 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2018 aa)
AMOTAngiomotin. (1045 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PATJPATJ crumbs cell polarity complex component. (1883 aa)
CD1DCD1d molecule. (337 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
RHOAUncharacterized protein. (104 aa)
SCRIBScribble planar cell polarity protein. (1660 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1387 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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