STRINGSTRING
TICAM2 TICAM2 TLR2 TLR2 MAPK3 MAPK3 LY96 LY96 PIK3R1 PIK3R1 PIK3R3 PIK3R3 CTSK CTSK MAPK10 MAPK10 IKBKE IKBKE IFNB1 IFNB1 TLR7 TLR7 MAP3K7 MAP3K7 TAB1 TAB1 IL12B IL12B TLR4 TLR4 CXCL8 CXCL8 MAPK9 MAPK9 TLR3 TLR3 CD80 CD80 CXCL9 CXCL9 MYD88 MYD88 TNF TNF NFKB1 NFKB1 TAB2 TAB2 IRF3 IRF3 MAP2K1 MAP2K1 IKBKG IKBKG MAP2K3 MAP2K3 CD86 CD86 IL1B IL1B PIK3CA PIK3CA RELA RELA TIRAP TIRAP MAP2K6 MAP2K6 LOC108524465 LOC108524465 TOLLIP TOLLIP CXCL11 CXCL11 CD14 CD14 CHUK CHUK TLR8 TLR8 FOS FOS IFNAR1 IFNAR1 IRF7 IRF7 SPP1 SPP1 FADD FADD MAPK1 MAPK1 IKBKB IKBKB MAPK14 MAPK14 LOC108541410 LOC108541410 MAP3K8 MAP3K8 CXCL10 CXCL10 TLR9 TLR9 MAP2K4 MAP2K4 CCL5 CCL5 IL12A IL12A MAPK13 MAPK13 AKT2 AKT2 AKT3 AKT3 MAPK11 MAPK11 PIK3CD PIK3CD CD40 CD40 TRAF6 TRAF6 MAP2K7 MAP2K7 STAT1 STAT1 LBP LBP IRAK4 IRAK4 NFKBIA NFKBIA RIPK1 RIPK1 IL6 IL6 TRAF3 TRAF3 IFNAR2 IFNAR2 CASP8 CASP8 IRF5 IRF5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
TLR2Toll-like receptor. (784 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
LY96Lymphocyte antigen 96. (160 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
IFNB1Interferon beta 1. (187 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (512 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (903 aa)
CD80CD80 molecule. (288 aa)
CXCL9C-X-C motif chemokine ligand 9. (125 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (426 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
CD86CD86 molecule. (329 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
RELAUncharacterized protein. (282 aa)
TIRAPTIR domain containing adaptor protein. (233 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LOC108524465C-C motif chemokine. (92 aa)
TOLLIPToll interacting protein. (274 aa)
CXCL11C-X-C motif chemokine. (94 aa)
CD14CD14 molecule. (384 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1016 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (553 aa)
IRF7Interferon regulatory factor 7. (503 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC108541410SCY domain-containing protein. (102 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (466 aa)
CXCL10C-X-C motif chemokine. (98 aa)
TLR9TIR domain-containing protein. (1033 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (408 aa)
CCL5C-C motif chemokine. (91 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CD40CD40 molecule. (278 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (414 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
LBPLipopolysaccharide binding protein. (481 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (461 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (672 aa)
IL6Interleukin 6. (214 aa)
TRAF3TNF receptor-associated factor. (477 aa)
IFNAR2Uncharacterized protein. (516 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
IRF5Interferon regulatory factor 5. (617 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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