52 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1374 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	MAPK10	Mitogen-activated protein kinase. (528 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
	IFNB1	Interferon beta 1. (187 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	MAPK9	Mitogen-activated protein kinase. (407 aa)
	DHX58	DExH-box helicase 58. (678 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1014 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	IRF3	IRF tryptophan pentad repeat domain-containing protein. (426 aa)
	TKFC	Triokinase and FMN cyclase. (575 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
	DDX3Y	DEAD-box helicase 3 Y-linked; Belongs to the DEAD box helicase family. (543 aa)
	RELA	Uncharacterized protein. (282 aa)
	TRADD	TNFRSF1A associated via death domain. (248 aa)
	NFKBIB	NFKB inhibitor beta. (338 aa)
	MAVS	Mitochondrial antiviral signaling protein. (539 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (522 aa)
	STING1	Transmembrane protein 173. (379 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (948 aa)
	AZI2	5-azacytidine induced 2. (392 aa)
	IRF7	Interferon regulatory factor 7. (503 aa)
	TANK	TRAF family member associated NFKB activator. (425 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	NLRX1	NLR family member X1. (972 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	ISG15	ISG15 ubiquitin like modifier. (167 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
	MAPK13	Mitogen-activated protein kinase. (365 aa)
	DDX58	DExD/H-box helicase 58. (914 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	OTUD5	OTU deubiquitinase 5. (553 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (625 aa)
	SIKE1	Suppressor of IKBKE 1. (207 aa)
	TRIM25	Tripartite motif containing 25. (630 aa)
	TBKBP1	TBK1 binding protein 1. (614 aa)
	IFNE	Interferon epsilon. (196 aa)
	NFKBIA	NFKB inhibitor alpha. (317 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (672 aa)
	TRAF3	TNF receptor-associated factor. (477 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (542 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG5	ENSRBIP00000033183	ENSRBIP00000002505	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	CASP10	ENSRBIP00000033183	ENSRBIP00000020065	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Caspase 10; Belongs to the peptidase C14A family.	0.400
ATG12	CASP8	ENSRBIP00000033183	ENSRBIP00000042695	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Caspase 8; Belongs to the peptidase C14A family.	0.560
ATG12	DDX58	ENSRBIP00000033183	ENSRBIP00000032975	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DExD/H-box helicase 58.	0.974
ATG12	FADD	ENSRBIP00000033183	ENSRBIP00000026089	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.689
ATG12	IFIH1	ENSRBIP00000033183	ENSRBIP00000010720	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Interferon induced with helicase C domain 1.	0.712
ATG12	MAVS	ENSRBIP00000033183	ENSRBIP00000019791	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Mitochondrial antiviral signaling protein.	0.976
ATG12	NLRX1	ENSRBIP00000033183	ENSRBIP00000026912	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1.	0.558
ATG5	ATG12	ENSRBIP00000002505	ENSRBIP00000033183	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	CASP10	ENSRBIP00000002505	ENSRBIP00000020065	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 10; Belongs to the peptidase C14A family.	0.576
ATG5	CASP8	ENSRBIP00000002505	ENSRBIP00000042695	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 8; Belongs to the peptidase C14A family.	0.706
ATG5	DDX58	ENSRBIP00000002505	ENSRBIP00000032975	Autophagy protein 5; Involved in autophagic vesicle formation.	DExD/H-box helicase 58.	0.974
ATG5	FADD	ENSRBIP00000002505	ENSRBIP00000026089	Autophagy protein 5; Involved in autophagic vesicle formation.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.774
ATG5	IFIH1	ENSRBIP00000002505	ENSRBIP00000010720	Autophagy protein 5; Involved in autophagic vesicle formation.	Interferon induced with helicase C domain 1.	0.675
ATG5	MAVS	ENSRBIP00000002505	ENSRBIP00000019791	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitochondrial antiviral signaling protein.	0.975
ATG5	NLRX1	ENSRBIP00000002505	ENSRBIP00000026912	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1.	0.573
ATG5	RIPK1	ENSRBIP00000002505	ENSRBIP00000041343	Autophagy protein 5; Involved in autophagic vesicle formation.	Receptor interacting serine/threonine kinase 1.	0.559
AZI2	CHUK	ENSRBIP00000025553	ENSRBIP00000023948	5-azacytidine induced 2.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.584
AZI2	IKBKB	ENSRBIP00000025553	ENSRBIP00000027811	5-azacytidine induced 2.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.584
AZI2	IKBKE	ENSRBIP00000025553	ENSRBIP00000004507	5-azacytidine induced 2.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.916