87 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	SRC	Tyrosine-protein kinase. (627 aa)
	PIK3R3	Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (310 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (524 aa)
	MAPK10	Mitogen-activated protein kinase. (528 aa)
	CBLB	Cbl proto-oncogene B. (1018 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
	CALML4	Calmodulin like 4. (192 aa)
	EGR3	Early growth response 3. (387 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
	NLRP3	NLR family pyrin domain containing 3. (1035 aa)
	MAPK9	Mitogen-activated protein kinase. (407 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (906 aa)
	IRF1	Interferon regulatory factor. (325 aa)
	NFATC4	Nuclear factor of activated T cells 4. (909 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	CARD9	Caspase recruitment domain family member 9. (536 aa)
	FCER1G	Fc fragment of IgE receptor Ig. (112 aa)
	CLEC4D	C-type lectin domain family 4 member D. (215 aa)
	NFATC2	Nuclear factor of activated T cells 2. (925 aa)
	CLEC4E	C-type lectin domain family 4 member E. (219 aa)
	NFATC3	Nuclear factor of activated T cells 3. (1056 aa)
	RAF1	Uncharacterized protein. (668 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (520 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
	MALT1	MALT1 paracaspase. (811 aa)
	CD209	CD209 molecule. (356 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	RELA	Uncharacterized protein. (282 aa)
	RRAS2	RAS related 2. (185 aa)
	CLEC1B	C-type lectin domain family 1 member B. (229 aa)
	PAK1	Non-specific serine/threonine protein kinase. (555 aa)
	LSP1	Lymphocyte specific protein 1. (454 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2637 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	CLEC6A	C-type lectin domain containing 6A. (209 aa)
	SYK	Uncharacterized protein. (331 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
	IL23A	Interleukin 23 subunit alpha. (189 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	CCL22	C-C motif chemokine. (93 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (947 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (948 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1536 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	NFATC1	Nuclear factor of activated T cells 1. (989 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	MRAS	Muscle RAS oncogene homolog. (208 aa)
	RELB	RELB proto-oncogene, NF-kB subunit. (541 aa)
	CASP1	Caspase 1; Belongs to the peptidase C14A family. (404 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
	CCL17	C-C motif chemokine. (91 aa)
	MAPK13	Mitogen-activated protein kinase. (365 aa)
	CALM3	Uncharacterized protein; Belongs to the calmodulin family. (163 aa)
	LOC108516810	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (330 aa)
	STAT2	Signal transducer and activator of transcription. (844 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	AKT3	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
	MAPKAPK2	MAPK activated protein kinase 2. (392 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	LOC108513176	Uncharacterized protein; Belongs to the peptidase C14A family. (406 aa)
	PLK3	Serine/threonine-protein kinase PLK. (647 aa)
	STAT1	Signal transducer and activator of transcription. (787 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	NFKBIA	NFKB inhibitor alpha. (317 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	CLEC7A	C-type lectin domain containing 7A. (257 aa)
	IL10	Interleukin 10. (178 aa)
	IL6	Interleukin 6. (214 aa)
	BCL10	BCL10 immune signaling adaptor. (233 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
	RHOA	Uncharacterized protein. (104 aa)
	RRAS	RAS related. (218 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (542 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT2	AKT3	ENSRBIP00000034007	ENSRBIP00000034274	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	0.939
AKT2	CALML3	ENSRBIP00000034007	ENSRBIP00000000722	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Calmodulin like 3; Belongs to the calmodulin family.	0.487
AKT2	CALML4	ENSRBIP00000034007	ENSRBIP00000005029	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Calmodulin like 4.	0.455
AKT2	CHUK	ENSRBIP00000034007	ENSRBIP00000023948	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.972
AKT2	IKBKB	ENSRBIP00000034007	ENSRBIP00000027811	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.962
AKT2	IKBKE	ENSRBIP00000034007	ENSRBIP00000004507	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.485
AKT2	IKBKG	ENSRBIP00000034007	ENSRBIP00000015173	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.925
AKT2	MAPK1	ENSRBIP00000034007	ENSRBIP00000026426	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.932
AKT2	MAPK11	ENSRBIP00000034007	ENSRBIP00000034454	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.933
AKT2	MAPK13	ENSRBIP00000034007	ENSRBIP00000032970	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.931
AKT2	MAPK14	ENSRBIP00000034007	ENSRBIP00000027919	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.933
AKT2	MAPK3	ENSRBIP00000034007	ENSRBIP00000000532	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.940
AKT2	MAPKAPK2	ENSRBIP00000034007	ENSRBIP00000034363	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	MAPK activated protein kinase 2.	0.434
AKT2	PIK3CA	ENSRBIP00000034007	ENSRBIP00000017817	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.967
AKT2	PIK3CD	ENSRBIP00000034007	ENSRBIP00000035123	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.954
AKT2	PIK3R1	ENSRBIP00000034007	ENSRBIP00000001603	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.960
AKT2	PIK3R3	ENSRBIP00000034007	ENSRBIP00000002180	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 3.	0.948
AKT2	RAF1	ENSRBIP00000034007	ENSRBIP00000010874	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.926
AKT2	SRC	ENSRBIP00000034007	ENSRBIP00000002089	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.547
AKT2	STAT1	ENSRBIP00000034007	ENSRBIP00000036941	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Signal transducer and activator of transcription.	0.410