STRINGSTRING
MAML2 MAML2 CD3D CD3D MAPK3 MAPK3 CD247 CD247 PPP3CA PPP3CA JAK1 JAK1 PPP3CB PPP3CB MAPK10 MAPK10 DLL1 DLL1 JAG2 JAG2 IL12B IL12B DLL3 DLL3 MAPK9 MAPK9 CD3G CD3G IL13 IL13 NFATC2 NFATC2 NFATC3 NFATC3 PPP3CC PPP3CC STAT6 STAT6 CD3E CD3E NFKB1 NFKB1 JAG1 JAG1 GATA3 GATA3 IKBKG IKBKG LOC108512973 LOC108512973 HLA-DQA1 HLA-DQA1 HLA-DQB1 HLA-DQB1 MAML3 MAML3 STAT4 STAT4 HLA-DRA HLA-DRA STAT5B STAT5B IL4R IL4R IFNGR2 IFNGR2 IL2RG IL2RG RELA RELA HLA-DPA1 HLA-DPA1 IL12RB1 IL12RB1 NFKBIB NFKBIB ENSRBIP00000019541 ENSRBIP00000019541 LOC108519884 LOC108519884 IFNGR1 IFNGR1 TYK2 TYK2 CHUK CHUK FOS FOS IL2RA IL2RA MAPK1 MAPK1 ZAP70 ZAP70 NFATC1 NFATC1 JAK3 JAK3 IKBKB IKBKB MAPK14 MAPK14 LOC108519885 LOC108519885 CD4 CD4 HLA-DOB HLA-DOB PRKCQ PRKCQ IFNG IFNG IL12A IL12A MAPK13 MAPK13 RBPJ RBPJ HLA-DPB1 HLA-DPB1 MAPK11 MAPK11 RUNX3 RUNX3 HLA-DOA HLA-DOA NOTCH2 NOTCH2 STAT1 STAT1 RBPJL RBPJL IL2 IL2 PLCG1 PLCG1 NFKBIA NFKBIA IL4 IL4 TBX21 TBX21 LAT LAT IL2RB IL2RB IL5 IL5 IL12RB2 IL12RB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAML2Mastermind like transcriptional coactivator 2. (1147 aa)
CD3DCD3d molecule. (171 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
CD247CD247 molecule. (165 aa)
PPP3CASerine/threonine-protein phosphatase. (310 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (748 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1075 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
DLL3Delta like canonical Notch ligand 3. (618 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
CD3GCD3g molecule. (181 aa)
IL13Interleukin 13. (146 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
NFATC3Nuclear factor of activated T cells 3. (1056 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
CD3ECD3e molecule. (198 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
GATA3GATA binding protein 3. (444 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
LOC108512973Ig-like domain-containing protein. (263 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (254 aa)
HLA-DQB1Ig-like domain-containing protein. (261 aa)
MAML3Mastermind like transcriptional coactivator 3. (1129 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
STAT5BSignal transducer and activator of transcription. (768 aa)
IL4RInterleukin 4 receptor. (825 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
RELAUncharacterized protein. (282 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (652 aa)
NFKBIBNFKB inhibitor beta. (338 aa)
ENSRBIP00000019541Ig-like domain-containing protein. (264 aa)
LOC108519884Ig-like domain-containing protein. (266 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
NFATC1Nuclear factor of activated T cells 1. (989 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC108519885Ig-like domain-containing protein. (266 aa)
CD4CD4 molecule. (458 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (159 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (531 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
NOTCH2Notch receptor 2. (2532 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (522 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
TBX21T-box transcription factor 21. (524 aa)
LATLinker for activation of T cells. (254 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (817 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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