STRINGSTRING
CD3D CD3D MAPK3 MAPK3 CD247 CD247 RUNX1 RUNX1 PPP3CA PPP3CA JAK1 JAK1 PPP3CB PPP3CB IRF4 IRF4 MAPK10 MAPK10 MTOR MTOR RORA RORA HSP90AB1-2 HSP90AB1-2 TGFB1 TGFB1 MAPK9 MAPK9 CD3G CD3G IL6R IL6R IL1R1 IL1R1 NFATC2 NFATC2 NFATC3 NFATC3 PPP3CC PPP3CC STAT6 STAT6 CD3E CD3E SMAD2 SMAD2 RARA RARA NFKB1 NFKB1 IL23R IL23R IL27RA IL27RA GATA3 GATA3 IKBKG IKBKG LOC108512973 LOC108512973 HLA-DQA1 HLA-DQA1 HLA-DQB1 HLA-DQB1 HLA-DRA HLA-DRA STAT5B STAT5B IL4R IL4R IFNGR2 IFNGR2 IL2RG IL2RG IL1B IL1B RELA RELA HLA-DPA1 HLA-DPA1 SMAD4 SMAD4 IL12RB1 IL12RB1 NFKBIB NFKBIB ENSRBIP00000019541 ENSRBIP00000019541 LOC108519884 LOC108519884 LOC108537061 LOC108537061 IFNGR1 IFNGR1 TGFBR2 TGFBR2 TYK2 TYK2 IL23A IL23A CHUK CHUK FOS FOS IL17F IL17F IL2RA IL2RA MAPK1 MAPK1 ZAP70 ZAP70 NFATC1 NFATC1 JAK3 JAK3 IKBKB IKBKB MAPK14 MAPK14 LOC108519885 LOC108519885 CD4 CD4 HLA-DOB HLA-DOB IL6ST IL6ST RXRG RXRG PRKCQ PRKCQ RXRB RXRB IFNG IFNG MAPK13 MAPK13 HLA-DPB1 HLA-DPB1 AHR AHR TGFBR1 TGFBR1 MAPK11 MAPK11 HLA-DOA HLA-DOA IL1RAP IL1RAP STAT1 STAT1 IL2 IL2 PLCG1 PLCG1 RXRA RXRA HIF1A HIF1A NFKBIA NFKBIA IL22 IL22 IL4 IL4 TBX21 TBX21 LAT LAT IL6 IL6 IL2RB IL2RB IL21 IL21 IL17A IL17A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD3DCD3d molecule. (171 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
CD247CD247 molecule. (165 aa)
RUNX1RUNX family transcription factor 1. (264 aa)
PPP3CASerine/threonine-protein phosphatase. (310 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
IRF4Interferon regulatory factor 4. (450 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
RORARAR related orphan receptor A. (555 aa)
HSP90AB1-2HATPase_c domain-containing protein. (724 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
CD3GCD3g molecule. (181 aa)
IL6RInterleukin 6 receptor. (499 aa)
IL1R1Interleukin 1 receptor type 1. (568 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
NFATC3Nuclear factor of activated T cells 3. (1056 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
CD3ECD3e molecule. (198 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
RARARetinoic acid receptor alpha. (478 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IL23RInterleukin 23 receptor. (629 aa)
IL27RAInterleukin 27 receptor subunit alpha. (724 aa)
GATA3GATA binding protein 3. (444 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
LOC108512973Ig-like domain-containing protein. (263 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (254 aa)
HLA-DQB1Ig-like domain-containing protein. (261 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
STAT5BSignal transducer and activator of transcription. (768 aa)
IL4RInterleukin 4 receptor. (825 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
RELAUncharacterized protein. (282 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (652 aa)
NFKBIBNFKB inhibitor beta. (338 aa)
ENSRBIP00000019541Ig-like domain-containing protein. (264 aa)
LOC108519884Ig-like domain-containing protein. (266 aa)
LOC108537061HATPase_c domain-containing protein. (384 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL17FInterleukin 17F. (163 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
NFATC1Nuclear factor of activated T cells 1. (989 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC108519885Ig-like domain-containing protein. (266 aa)
CD4CD4 molecule. (458 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
IL6STUncharacterized protein. (330 aa)
RXRGRetinoid X receptor gamma. (463 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
RXRBRetinoid X receptor beta. (508 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (159 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
AHRUncharacterized protein. (833 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
IL1RAPInterleukin 1 receptor accessory protein. (680 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
RXRARetinoid X receptor alpha. (492 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
IL22Interleukin 22. (179 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
TBX21T-box transcription factor 21. (524 aa)
LATLinker for activation of T cells. (254 aa)
IL6Interleukin 6. (214 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
IL17AInterleukin 17A. (155 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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