STRINGSTRING
PAK5 PAK5 CD3D CD3D MAPK3 MAPK3 CD247 CD247 PIK3R1 PIK3R1 PIK3R3 PIK3R3 PPP3CA PPP3CA PPP3CB PPP3CB PAK6 PAK6 MAPK10 MAPK10 CBLB CBLB PAK4 PAK4 CARD11 CARD11 MAP3K7 MAP3K7 DLG1 DLG1 FYN FYN MAPK9 MAPK9 CD3G CD3G CD8B CD8B NFATC2 NFATC2 NFATC3 NFATC3 RAF1 RAF1 PPP3CC PPP3CC CD3E CD3E TNF TNF CD28 CD28 NFKB1 NFKB1 ICOS ICOS NCK1 NCK1 RASGRP1 RASGRP1 MAP2K1 MAP2K1 IKBKG IKBKG MALT1 MALT1 GRB2 GRB2 PIK3CA PIK3CA LOC108522676 LOC108522676 RELA RELA CD8A CD8A LCP2 LCP2 CDK4 CDK4 NFKBIB NFKBIB PAK1 PAK1 PAK2 PAK2 HRAS HRAS CD40LG CD40LG CHUK CHUK MAP3K14 MAP3K14 GSK3B GSK3B FOS FOS MAPK1 MAPK1 GRAP2 GRAP2 KRAS KRAS ZAP70 ZAP70 NFATC1 NFATC1 CSF2 CSF2 IKBKB IKBKB MAPK14 MAPK14 MAP3K8 MAP3K8 CD4 CD4 PRKCQ PRKCQ PDCD1 PDCD1 CTLA4 CTLA4 IFNG IFNG MAPK13 MAPK13 ITK ITK SOS1 SOS1 AKT2 AKT2 AKT3 AKT3 MAPK11 MAPK11 VAV1 VAV1 NCK2 NCK2 PIK3CD PIK3CD SOS2 SOS2 MAP2K7 MAP2K7 CDC42 CDC42 IL2 IL2 PLCG1 PLCG1 NFKBIA NFKBIA NRAS NRAS PTPN6 PTPN6 IL4 IL4 PTPRC PTPRC LAT LAT IL10 IL10 BCL10 BCL10 IL5 IL5 RHOA RHOA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAK5Non-specific serine/threonine protein kinase. (719 aa)
CD3DCD3d molecule. (171 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
CD247CD247 molecule. (165 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PPP3CASerine/threonine-protein phosphatase. (310 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
CBLBCbl proto-oncogene B. (1018 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (861 aa)
FYNTyrosine-protein kinase. (537 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
CD3GCD3g molecule. (181 aa)
CD8BIg-like domain-containing protein. (243 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
NFATC3Nuclear factor of activated T cells 3. (1056 aa)
RAF1Uncharacterized protein. (668 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
CD3ECD3e molecule. (198 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CD28CD28 molecule. (220 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
ICOSInducible T cell costimulator. (199 aa)
NCK1NCK adaptor protein 1. (371 aa)
RASGRP1RAS guanyl releasing protein 1. (841 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
MALT1MALT1 paracaspase. (811 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
LOC108522676Protein kinase domain-containing protein. (299 aa)
RELAUncharacterized protein. (282 aa)
CD8ACD8a molecule. (235 aa)
LCP2Lymphocyte cytosolic protein 2. (531 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
NFKBIBNFKB inhibitor beta. (338 aa)
PAK1Non-specific serine/threonine protein kinase. (555 aa)
PAK2Non-specific serine/threonine protein kinase. (539 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
NFATC1Nuclear factor of activated T cells 1. (989 aa)
CSF2Colony stimulating factor 2. (144 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (466 aa)
CD4CD4 molecule. (458 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PDCD1Programmed cell death 1. (288 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (159 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ITKTyrosine-protein kinase. (593 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1293 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
VAV1Vav guanine nucleotide exchange factor 1. (843 aa)
NCK2Cytoplasmic protein. (380 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1268 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (414 aa)
CDC42Uncharacterized protein. (191 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (602 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
LATLinker for activation of T cells. (254 aa)
IL10Interleukin 10. (178 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
RHOAUncharacterized protein. (104 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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