58 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
	PLA2G4B	Phospholipase A2. (781 aa)
	PLA2G4F	Phospholipase A2. (827 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	PIK3R3	Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
	MAPK10	Mitogen-activated protein kinase. (528 aa)
	FCER1A	Fc fragment of IgE receptor Ia. (260 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	MAPK9	Mitogen-activated protein kinase. (407 aa)
	IL13	Interleukin 13. (146 aa)
	FCER1G	Fc fragment of IgE receptor Ig. (112 aa)
	RAF1	Uncharacterized protein. (668 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	PLA2G4C	Phospholipase A2 group IVC. (551 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	PLA2G4A	Phospholipase A2. (738 aa)
	GAB2	GRB2 associated binding protein 2. (678 aa)
	ALOX5	Arachidonate 5-lipoxygenase. (674 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	IL3	Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (152 aa)
	MAP2K3	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	LCP2	Lymphocyte cytosolic protein 2. (531 aa)
	INPP5D	Inositol polyphosphate-5-phosphatase D. (1194 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (604 aa)
	ENSRBIP00000020710	Ig-like domain-containing protein. (124 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	SYK	Uncharacterized protein. (331 aa)
	PLA2G4E	Phospholipase A2. (869 aa)
	MS4A2	Membrane spanning 4-domains A2. (260 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	CSF2	Colony stimulating factor 2. (144 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	LOC108522153	Ig-like domain-containing protein. (198 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (408 aa)
	MAPK13	Mitogen-activated protein kinase. (365 aa)
	PLA2G4D	Phospholipase A2. (816 aa)
	LOC108516810	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (330 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1293 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	AKT3	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (843 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1268 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (414 aa)
	ALOX5AP	Arachidonate 5-lipoxygenase activating protein. (217 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	RAC2	Rac family small GTPase 2. (192 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
	LAT	Linker for activation of T cells. (254 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	BTK	Tyrosine-protein kinase. (673 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT2	AKT3	ENSRBIP00000034007	ENSRBIP00000034274	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	0.939
AKT2	FYN	ENSRBIP00000034007	ENSRBIP00000006312	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.524
AKT2	IL4	ENSRBIP00000034007	ENSRBIP00000040124	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.494
AKT2	LYN	ENSRBIP00000034007	ENSRBIP00000036574	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.466
AKT2	MAP2K4	ENSRBIP00000034007	ENSRBIP00000030027	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.920
AKT2	MAPK1	ENSRBIP00000034007	ENSRBIP00000026426	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.932
AKT2	MAPK11	ENSRBIP00000034007	ENSRBIP00000034454	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.933
AKT2	MAPK13	ENSRBIP00000034007	ENSRBIP00000032970	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.931
AKT2	MAPK14	ENSRBIP00000034007	ENSRBIP00000027919	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.933
AKT2	MAPK3	ENSRBIP00000034007	ENSRBIP00000000532	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.940
AKT2	PIK3CA	ENSRBIP00000034007	ENSRBIP00000017817	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.967
AKT2	PIK3CD	ENSRBIP00000034007	ENSRBIP00000035123	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.954
AKT2	PIK3R1	ENSRBIP00000034007	ENSRBIP00000001603	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.960
AKT2	PIK3R3	ENSRBIP00000034007	ENSRBIP00000002180	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 3.	0.948
AKT2	RAF1	ENSRBIP00000034007	ENSRBIP00000010874	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.926
AKT3	AKT2	ENSRBIP00000034274	ENSRBIP00000034007	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.939
AKT3	FYN	ENSRBIP00000034274	ENSRBIP00000006312	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.494
AKT3	IL4	ENSRBIP00000034274	ENSRBIP00000040124	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.512
AKT3	LYN	ENSRBIP00000034274	ENSRBIP00000036574	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.456
AKT3	MAP2K4	ENSRBIP00000034274	ENSRBIP00000030027	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.922