STRINGSTRING
MAPK3 MAPK3 MATK MATK CALML3 CALML3 MAP3K1 MAP3K1 CRK CRK PIK3R1 PIK3R1 PIK3R3 PIK3R3 FASLG FASLG MAPK10 MAPK10 RAP1A RAP1A RIPK2 RIPK2 RPS6KA2 RPS6KA2 CALML4 CALML4 NTF4 NTF4 RAP1B RAP1B IRAK3 IRAK3 MAPK9 MAPK9 ABL1 ABL1 BDNF BDNF CAMK2D CAMK2D SORT1 SORT1 CALM1 CALM1 RPS6KA1 RPS6KA1 SHC2 SHC2 SH2B2 SH2B2 BCL2 BCL2 RAF1 RAF1 SH2B1 SH2B1 ARHGDIB ARHGDIB NFKB1 NFKB1 ZNF274 ZNF274 IRS1 IRS1 PLCG2 PLCG2 RPS6KA3 RPS6KA3 SHC4 SHC4 ARHGDIG ARHGDIG MAP2K1 MAP2K1 GRB2 GRB2 ATF4 ATF4 TP73 TP73 PIK3CA PIK3CA NTRK3 NTRK3 RELA RELA NFKBIB NFKBIB NTF3 NTF3 ARHGDIA ARHGDIA BRAF BRAF HRAS HRAS KIDINS220 KIDINS220 CAMK4 CAMK4 PRKCD PRKCD PRDM4 PRDM4 GSK3B GSK3B MAPK1 MAPK1 KRAS KRAS IKBKB IKBKB MAPK14 MAPK14 TP53 TP53 FRS2 FRS2 CRKL CRKL MAP3K5 MAP3K5 GAB1 GAB1 YWHAE YWHAE SH2B3 SH2B3 MAP3K3 MAP3K3 PSEN2 PSEN2 MAPK13 MAPK13 CALM3 CALM3 SOS1 SOS1 AKT2 AKT2 AKT3 AKT3 CAMK2A CAMK2A MAPKAPK2 MAPKAPK2 MAPK11 MAPK11 FOXO3 FOXO3 PIK3CD PIK3CD BAX BAX TRAF6 TRAF6 SOS2 SOS2 MAP2K7 MAP2K7 RPS6KA5 RPS6KA5 NTRK2 NTRK2 CDC42 CDC42 MAP2K5 MAP2K5 MAPK7 MAPK7 PLCG1 PLCG1 IRAK4 IRAK4 NFKBIA NFKBIA NRAS NRAS BEX3 BEX3 NTRK1 NTRK1 NGF NGF SHC1 SHC1 SHC3 SHC3 RHOA RHOA BAD BAD NGFR NGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
MATKTyrosine-protein kinase. (554 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1374 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (443 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
CALML4Calmodulin like 4. (192 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
RAP1BUncharacterized protein. (184 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
SORT1Sortilin. (728 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
SHC2Uncharacterized protein. (421 aa)
SH2B2SH2B adaptor protein 2. (659 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
RAF1Uncharacterized protein. (668 aa)
SH2B1SH2B adaptor protein 1. (757 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (201 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
ZNF274Zinc finger protein 274. (654 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
RPS6KA3Uncharacterized protein. (66 aa)
SHC4SHC adaptor protein 4. (630 aa)
ARHGDIGRho GDP dissociation inhibitor gamma. (218 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ATF4Activating transcription factor 4. (351 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
RELAUncharacterized protein. (282 aa)
NFKBIBNFKB inhibitor beta. (338 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (278 aa)
ARHGDIAUncharacterized protein. (235 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (753 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
KIDINS220Kinase D interacting substrate 220. (1771 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (472 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
GAB1GRB2 associated binding protein 1. (722 aa)
YWHAE14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
SH2B3SH2B adaptor protein 3. (568 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (163 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1293 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
MAPKAPK2MAPK activated protein kinase 2. (392 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
FOXO3Forkhead box O3. (672 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1268 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (414 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (684 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
CDC42Uncharacterized protein. (191 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (461 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BEX3Brain expressed X-linked 3. (123 aa)
NTRK1Tyrosine-protein kinase receptor. (816 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
SHC1SHC adaptor protein 1. (584 aa)
SHC3SHC adaptor protein 3. (596 aa)
RHOAUncharacterized protein. (104 aa)
BADBCL2 associated agonist of cell death. (167 aa)
NGFRNerve growth factor receptor. (427 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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