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MAPK3 MAPK3 CACNA1B CACNA1B PRKCG PRKCG PIK3R1 PIK3R1 CHRM3 CHRM3 PIK3R3 PIK3R3 CREB3L2 CREB3L2 CACNA1A CACNA1A GNA11 GNA11 ADCY6 ADCY6 KCNJ2 KCNJ2 FYN FYN CACNA1S CACNA1S GNB4 GNB4 KCNJ14 KCNJ14 PLCB1 PLCB1 ENSRBIP00000007423 ENSRBIP00000007423 CHRM1 CHRM1 CHRNB4 CHRNB4 CAMK2D CAMK2D CHRNA6 CHRNA6 GNG7 GNG7 GNG13 GNG13 BCL2 BCL2 CHRM5 CHRM5 CREB3L1 CREB3L1 KCNJ3 KCNJ3 PIK3R6 PIK3R6 MAP2K1 MAP2K1 ADCY7 ADCY7 ATF4 ATF4 GNB3 GNB3 PIK3CA PIK3CA KCNQ2 KCNQ2 GNG4 GNG4 GNG5 GNG5 SLC5A7 SLC5A7 GNG11 GNG11 PRKCA PRKCA ADCY9 ADCY9 CACNA1D CACNA1D ADCY3 ADCY3 HRAS HRAS CAMK4 CAMK4 GNG2 GNG2 ITPR2 ITPR2 ITPR1 ITPR1 ADCY8 ADCY8 CREB3 CREB3 ADCY2 ADCY2 FOS FOS GNG3 GNG3 MAPK1 MAPK1 KRAS KRAS GNAI2 GNAI2 CHRNB2 CHRNB2 GNG12 GNG12 KCNJ6 KCNJ6 CREB5 CREB5 GNB1 GNB1 GNG8 GNG8 CREB1 CREB1 AKT2 AKT2 ADCY5 ADCY5 AKT3 AKT3 CAMK2A CAMK2A CHRNA4 CHRNA4 PRKACB PRKACB GNB5 GNB5 CACNA1F CACNA1F PIK3CD PIK3CD ADCY1 ADCY1 KCNQ4 KCNQ4 GNAQ GNAQ ACHE ACHE PLCB2 PLCB2 PLCB4 PLCB4 CHAT CHAT NRAS NRAS CHRNA3 CHRNA3 SLC18A3 SLC18A3 GNAI3 GNAI3 CREB3L3 CREB3L3 PIK3CG PIK3CG KCNQ1 KCNQ1 ITPR3 ITPR3 KCNQ3 KCNQ3 KCNQ5 KCNQ5 PIK3R5 PIK3R5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2299 aa)
PRKCGProtein kinase C. (726 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2305 aa)
GNA11G protein subunit alpha 11. (354 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1169 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
FYNTyrosine-protein kinase. (537 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
GNB4G protein subunit beta 4. (340 aa)
KCNJ14Potassium voltage-gated channel subfamily J member 14. (436 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1079 aa)
ENSRBIP00000007423Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (492 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG13G protein subunit gamma 13. (67 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (442 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
ATF4Activating transcription factor 4. (351 aa)
GNB3G protein subunit beta 3. (340 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
KCNQ2Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. (833 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (604 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2180 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (472 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (102 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2637 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
ADCY8Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (657 aa)
CREB3cAMP responsive element binding protein 3. (370 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (518 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (414 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (503 aa)
GNB1G protein subunit beta 1. (340 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (575 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNB5G protein subunit beta 5. (403 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1818 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (700 aa)
GNAQG protein subunit alpha q. (359 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (631 aa)
PLCB2Phosphoinositide phospholipase C. (991 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1199 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (631 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (503 aa)
SLC18A3Solute carrier family 18 member A3. (457 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (483 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (452 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
KCNQ3Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family. (854 aa)
KCNQ5Potassium voltage-gated channel subfamily Q member 5. (951 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (879 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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