STRINGSTRING
PAK5 PAK5 MAPK3 MAPK3 LOC108533552 LOC108533552 FN1 FN1 CFL2 CFL2 CRK CRK IQGAP1 IQGAP1 FGF10 FGF10 PIK3R1 PIK3R1 PDGFD PDGFD LOC108530360 LOC108530360 GSN GSN FGF4 FGF4 CHRM3 CHRM3 SRC SRC PFN1-2 PFN1-2 PIK3R3 PIK3R3 PFN3 PFN3 CFL1 CFL1 PAK6 PAK6 ARPC4 ARPC4 ACTB ACTB LPAR5 LPAR5 FGF20 FGF20 PAK4 PAK4 SLC9A1 SLC9A1 ARPC1B ARPC1B BRK1 BRK1 PPP1R12C PPP1R12C SPATA13 SPATA13 KNG1 KNG1 CHRM1 CHRM1 MYLK3 MYLK3 ITGAE ITGAE VCL VCL LPAR2 LPAR2 ITGB3 ITGB3 ARAF ARAF MYL9 MYL9 FGF1 FGF1 GNA13 GNA13 ARPC5 ARPC5 LIMK1 LIMK1 DIAPH3 DIAPH3 ROCK1 ROCK1 PPP1CB PPP1CB RAF1 RAF1 CXCR4 CXCR4 CHRM5 CHRM5 FGD3 FGD3 ARHGAP35 ARHGAP35 PIP4K2B PIP4K2B ARPC3 ARPC3 PDGFC PDGFC FGF3 FGF3 BCAR1 BCAR1 LPAR4 LPAR4 PPP1CC PPP1CC FGFR2 FGFR2 ITGA3 ITGA3 MAP2K1 MAP2K1 PDGFRB PDGFRB PXN PXN INS INS ITGA11 ITGA11 EGF EGF FGF16 FGF16 PDGFB PDGFB FGF19 FGF19 WASL WASL NCKAP1L NCKAP1L FGFR1 FGFR1 ITGAV ITGAV PIK3CA PIK3CA APC APC LOC108522676 LOC108522676 RDX RDX ITGA5 ITGA5 MYL2 MYL2 TIAM1 TIAM1 GNA12 GNA12 RRAS2 RRAS2 FGD1 FGD1 MYH14 MYH14 IQGAP2 IQGAP2 PAK1 PAK1 MYL12B MYL12B ITGB7 ITGB7 PAK2 PAK2 ITGB1 ITGB1 INSRR INSRR BRAF BRAF HRAS HRAS MYH10 MYH10 ITGA10 ITGA10 MOS MOS PIP4K2C PIP4K2C MYLK MYLK ARPC2 ARPC2 BAIAP2 BAIAP2 ITGA2B ITGA2B ITGA9 ITGA9 MYLK2 MYLK2 IQGAP3 IQGAP3 ARHGEF7 ARHGEF7 ITGA1 ITGA1 LIMK2 LIMK2 ARHGEF12 ARHGEF12 TMSB4X TMSB4X GIT1 GIT1 SSH2 SSH2 MYLK4 MYLK4 ACTN1 ACTN1 ITGA8 ITGA8 ITGAL ITGAL F2R F2R EZR EZR MAPK1 MAPK1 KRAS KRAS FGF7 FGF7 ITGAX ITGAX PDGFA PDGFA FGF23 FGF23 FGF8 FGF8 MRAS MRAS CRKL CRKL FGF9 FGF9 SSH1 SSH1 ITGB5 ITGB5 FGF6 FGF6 GNG12 GNG12 FGF17 FGF17 CXCL12 CXCL12 WASF1 WASF1 SOS1 SOS1 FGFR3 FGFR3 ITGA4 ITGA4 ACTN4 ACTN4 MYL5 MYL5 ITGB8 ITGB8 PIP5K1A PIP5K1A VAV1 VAV1 ITGB4 ITGB4 NCKAP1 NCKAP1 SCIN SCIN ITGA6 ITGA6 ITGB6 ITGB6 ITGA2 ITGA2 PIK3CD PIK3CD FGF5 FGF5 PFN2 PFN2 ITGAM ITGAM LOC108513979 LOC108513979 SOS2 SOS2 MYL7 MYL7 MSN MSN WASF2 WASF2 EGFR EGFR FGF18 FGF18 PDGFRA PDGFRA CDC42 CDC42 PIP5K1B PIP5K1B CYFIP2 CYFIP2 MYH9 MYH9 ARPC5L ARPC5L NRAS NRAS MYH11 MYH11 SSH3 SSH3 RAC2 RAC2 DOCK1 DOCK1 PPP1CA PPP1CA PIKFYVE PIKFYVE RHOA RHOA ITGA7 ITGA7 PIP5K1C PIP5K1C RRAS RRAS MYLPF MYLPF ROCK2 ROCK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAK5Non-specific serine/threonine protein kinase. (719 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
LOC108533552Uncharacterized protein. (177 aa)
FN1Fibronectin 1. (2477 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1630 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PDGFDPlatelet derived growth factor D. (398 aa)
LOC108530360Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
GSNGelsolin. (782 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
SRCTyrosine-protein kinase. (627 aa)
PFN1-2Profilin; Belongs to the profilin family. (140 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (189 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (189 aa)
ACTBActin beta. (379 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (375 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (811 aa)
SPATA13Uncharacterized protein. (1325 aa)
KNG1Kininogen 1. (644 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
MYLK3Myosin light chain kinase 3. (818 aa)
ITGAEIntegrin subunit alpha E; Belongs to the integrin alpha chain family. (1137 aa)
VCLVinculin. (1118 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MYL9Myosin light chain 9. (172 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
GNA13G protein subunit alpha 13. (353 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
LIMK1LIM domain kinase 1. (677 aa)
DIAPH3Diaphanous related formin 3. (1190 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1341 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
RAF1Uncharacterized protein. (668 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (415 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
FGD3FYVE, RhoGEF and PH domain containing 3. (672 aa)
ARHGAP35Rho GTPase activating protein 35. (1281 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa)
ARPC3Uncharacterized protein. (134 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (906 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1087 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
PXNPaxillin. (1083 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1233 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (237 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
WASLWASP like actin nucleation promoting factor. (504 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
FGFR1Fibroblast growth factor receptor. (829 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
APCAPC regulator of WNT signaling pathway. (2768 aa)
LOC108522676Protein kinase domain-containing protein. (299 aa)
RDXRadixin. (604 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1051 aa)
MYL2Myosin light chain 2. (166 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
GNA12G protein subunit alpha 12. (322 aa)
RRAS2RAS related 2. (185 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (939 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1869 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1575 aa)
PAK1Non-specific serine/threonine protein kinase. (555 aa)
MYL12BUncharacterized protein. (172 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
PAK2Non-specific serine/threonine protein kinase. (539 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (937 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (753 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1168 aa)
MOSMOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (336 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (421 aa)
MYLKMyosin light chain kinase. (1656 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (306 aa)
BAIAP2BAI1 associated protein 2. (605 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1105 aa)
ITGA9Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (548 aa)
MYLK2Myosin light chain kinase 2. (603 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1663 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (755 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
LIMK2LIM domain kinase 2. (639 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1536 aa)
TMSB4XThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
GIT1GIT ArfGAP 1. (817 aa)
SSH2Slingshot protein phosphatase 2. (1450 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (388 aa)
ACTN1Actinin alpha 1. (910 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1155 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
EZREzrin. (588 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ITGAXIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1172 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (303 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SSH1Slingshot protein phosphatase 1. (1048 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
WASF1WASP family member 1. (559 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1293 aa)
FGFR3Fibroblast growth factor receptor. (783 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
ACTN4Actinin alpha 4. (931 aa)
MYL5Myosin light chain 5. (173 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (745 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
VAV1Vav guanine nucleotide exchange factor 1. (843 aa)
ITGB4Integrin beta. (1823 aa)
NCKAP1NCK associated protein 1. (1112 aa)
SCINScinderin. (715 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (771 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
PFN2Profilin; Belongs to the profilin family. (183 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
LOC108513979G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (266 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1268 aa)
MYL7Myosin light chain 7. (199 aa)
MSNMoesin. (577 aa)
WASF2WASP family member 2. (498 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CDC42Uncharacterized protein. (191 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1962 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2018 aa)
SSH3Slingshot protein phosphatase 3. (657 aa)
RAC2Rac family small GTPase 2. (192 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1930 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2095 aa)
RHOAUncharacterized protein. (104 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (376 aa)
RRASRAS related. (218 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (169 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1387 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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