(107 nodes) Insulin signaling pathway network (Rhinopithecus bieti)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
	SREBF1	Sterol regulatory element binding transcription factor 1. (1047 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	PPP1R3B	Protein phosphatase 1 regulatory subunit. (285 aa)
	CRK	CRK proto-oncogene, adaptor protein. (304 aa)
	SOCS1	Suppressor of cytokine signaling 1. (215 aa)
	PRKAG3	Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	PIK3R3	Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (435 aa)
	PRKAR2A	Protein kinase cAMP-dependent type II regulatory subunit alpha. (376 aa)
	MAPK10	Mitogen-activated protein kinase. (528 aa)
	CBLB	Cbl proto-oncogene B. (1018 aa)
	SOCS4	Suppressor of cytokine signaling 4. (439 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
	CALML4	Calmodulin like 4. (192 aa)
	LIPE	Lipase E, hormone sensitive type. (929 aa)
	RHEB	Ras homolog, mTORC1 binding. (183 aa)
	ELK1	ETS domain-containing protein. (428 aa)
	FOXO1	Forkhead box O1. (539 aa)
	RHOQ	Uncharacterized protein. (204 aa)
	MAPK9	Mitogen-activated protein kinase. (407 aa)
	HKDC1	Hexokinase domain containing 1. (917 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (606 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	SOCS2	Suppressor of cytokine signaling 2. (233 aa)
	PRKAG1	Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
	SHC2	Uncharacterized protein. (421 aa)
	SH2B2	SH2B adaptor protein 2. (659 aa)
	LOC108513197	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	PRKAB2	Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
	RAF1	Uncharacterized protein. (668 aa)
	FBP2	Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
	EIF4EBP1	Uncharacterized protein. (118 aa)
	SOCS3	Uncharacterized protein. (225 aa)
	IRS1	Insulin receptor substrate 1. (1241 aa)
	SHC4	SHC adaptor protein 4. (630 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	PHKG2	Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (410 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	IRS2	Insulin receptor substrate 2. (904 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (798 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	PYGM	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
	GYS1	Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
	SLC2A4	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	PRKAB1	Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
	GYS2	Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
	HK2	Hexokinase 2. (917 aa)
	GCK	Phosphotransferase. (466 aa)
	FBP1	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (293 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (753 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	G6PC3	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
	FASN	Fatty acid synthase. (2477 aa)
	PRKAR2B	Protein kinase cAMP-dependent type II regulatory subunit beta. (412 aa)
	TSC1	TSC complex subunit 1. (1164 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
	PPP1R3D	Protein phosphatase 1 regulatory subunit. (294 aa)
	HK3	Hexokinase 3. (960 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (574 aa)
	PPP1R3F	Protein phosphatase 1 regulatory subunit 3F. (740 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
	PPP1R3E	Protein phosphatase 1 regulatory subunit 3E. (266 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
	PHKA2	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1222 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (240 aa)
	EIF4E1B	Eukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
	INPP5A	Inositol polyphosphate-5-phosphatase A. (412 aa)
	TSC2	TSC complex subunit 2. (1805 aa)
	CALM3	Uncharacterized protein; Belongs to the calmodulin family. (163 aa)
	INPPL1	Inositol polyphosphate phosphatase like 1. (1257 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1293 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	AKT3	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
	PTPRF	Protein tyrosine phosphatase receptor type F. (1912 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2458 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1268 aa)
	HK1	Hexokinase 1. (1036 aa)
	PRKAR1B	Protein kinase cAMP-dependent type I regulatory subunit beta. (452 aa)
	IRS4	Insulin receptor substrate 4. (1247 aa)
	PPP1R3A	Protein phosphatase 1 regulatory subunit 3A. (1118 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (539 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (581 aa)
	G6PC	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
	PYGB	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (884 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	SHC1	SHC adaptor protein 1. (584 aa)
	SHC3	SHC adaptor protein 3. (596 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
	BAD	BCL2 associated agonist of cell death. (167 aa)
	PYGL	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
	EXOC7	Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (707 aa)
	EIF4E2	Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (244 aa)
	PPP1R3C	Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACB	FASN	ENSRBIP00000035944	ENSRBIP00000023412	Acetyl-CoA carboxylase beta.	Fatty acid synthase.	0.969
ACACB	PKLR	ENSRBIP00000035944	ENSRBIP00000028487	Acetyl-CoA carboxylase beta.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.429
ACACB	PRKAA1	ENSRBIP00000035944	ENSRBIP00000025562	Acetyl-CoA carboxylase beta.	Non-specific serine/threonine protein kinase.	0.920
ACACB	PRKAA2	ENSRBIP00000035944	ENSRBIP00000038456	Acetyl-CoA carboxylase beta.	Non-specific serine/threonine protein kinase.	0.921
ACACB	PRKAB1	ENSRBIP00000035944	ENSRBIP00000020229	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit beta 1.	0.912
ACACB	PRKAB2	ENSRBIP00000035944	ENSRBIP00000010718	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit beta 2.	0.923
ACACB	PRKAG1	ENSRBIP00000035944	ENSRBIP00000009638	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit gamma 1.	0.909
ACACB	PRKAG3	ENSRBIP00000035944	ENSRBIP00000001359	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit gamma 3.	0.907
ACACB	SREBF1	ENSRBIP00000035944	ENSRBIP00000000450	Acetyl-CoA carboxylase beta.	Sterol regulatory element binding transcription factor 1.	0.546
AKT2	AKT3	ENSRBIP00000034007	ENSRBIP00000034274	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	0.939
AKT2	BAD	ENSRBIP00000034007	ENSRBIP00000041804	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 associated agonist of cell death.	0.952
AKT2	CALML3	ENSRBIP00000034007	ENSRBIP00000000722	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Calmodulin like 3; Belongs to the calmodulin family.	0.487
AKT2	CALML4	ENSRBIP00000034007	ENSRBIP00000005029	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Calmodulin like 4.	0.455
AKT2	FOXO1	ENSRBIP00000034007	ENSRBIP00000006591	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O1.	0.976
AKT2	GSK3B	ENSRBIP00000034007	ENSRBIP00000024352	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.962
AKT2	IKBKB	ENSRBIP00000034007	ENSRBIP00000027811	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.962
AKT2	INPPL1	ENSRBIP00000034007	ENSRBIP00000033248	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inositol polyphosphate phosphatase like 1.	0.437
AKT2	INS	ENSRBIP00000034007	ENSRBIP00000015729	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.521
AKT2	IRS1	ENSRBIP00000034007	ENSRBIP00000013251	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 1.	0.497
AKT2	MAPK1	ENSRBIP00000034007	ENSRBIP00000026426	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.932