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| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa) |
| | PRKCG | Protein kinase C. (726 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa) |
| | SRC | Tyrosine-protein kinase. (627 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | THRB | Thyroid hormone receptor beta. (476 aa) |
| | ACTB | Actin beta. (379 aa) |
| | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha. (1034 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa) |
| | SLC9A1 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa) |
| | PLCD1 | Phosphoinositide phospholipase C. (777 aa) |
| | PFKL | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (774 aa) |
| | RHEB | Ras homolog, mTORC1 binding. (183 aa) |
| | KAT2A | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa) |
| | FOXO1 | Forkhead box O1. (539 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1079 aa) |
| | PLN | Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa) |
| | ATP1B3 | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (265 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (788 aa) |
| | PLCD4 | Phosphoinositide phospholipase C. (799 aa) |
| | ATP1A4 | Sodium/potassium-transporting ATPase subunit alpha. (1029 aa) |
| | RAF1 | Uncharacterized protein. (668 aa) |
| | RCAN2 | Regulator of calcineurin 2. (243 aa) |
| | NOTCH4 | Notch receptor 4. (2000 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (372 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | NCOA3 | Nuclear receptor coactivator. (1418 aa) |
| | PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. (522 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1547 aa) |
| | LOC108527145 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (469 aa) |
| | DIO1 | Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (248 aa) |
| | ITGAV | Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa) |
| | MED30 | Mediator complex subunit 30. (178 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (604 aa) |
| | SLC2A1 | Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa) |
| | RCAN1 | Regulator of calcineurin 1. (255 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | NCOA1 | Nuclear receptor coactivator. (1433 aa) |
| | ATP2A2 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1037 aa) |
| | PLCD3 | Phosphoinositide phospholipase C. (785 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa) |
| | SLC16A2 | Solute carrier family 16 member 2. (537 aa) |
| | MED16 | Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (877 aa) |
| | CCND1 | Cyclin D1. (156 aa) |
| | SLC16A10 | Solute carrier family 16 member 10. (515 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | MED13 | Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2143 aa) |
| | THRA | Thyroid hormone receptor alpha. (524 aa) |
| | ATP1B4 | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (353 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | MED24 | Mediator complex subunit 24. (1028 aa) |
| | PFKM | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa) |
| | CREBBP | CREB binding protein. (2422 aa) |
| | RXRG | Retinoid X receptor gamma. (463 aa) |
| | MED12 | Mediator complex subunit 12. (2055 aa) |
| | RXRB | Retinoid X receptor beta. (508 aa) |
| | MED12L | Mediator complex subunit 12L. (2142 aa) |
| | TSC2 | TSC complex subunit 2. (1805 aa) |
| | LOC108520497 | PFK domain-containing protein. (218 aa) |
| | MED13L | Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2050 aa) |
| | HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | EP300 | E1A binding protein p300. (2296 aa) |
| | ATP1B1 | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa) |
| | GATA4 | GATA binding protein 4. (432 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | AKT3 | AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa) |
| | MED17 | Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (652 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa) |
| | SLCO1C1 | Solute carrier organic anion transporter family member. (730 aa) |
| | NCOR1 | Nuclear receptor corepressor 1. (2441 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | NOTCH2 | Notch receptor 2. (2532 aa) |
| | STAT1 | Signal transducer and activator of transcription. (787 aa) |
| | MED27 | Mediator complex subunit 27. (311 aa) |
| | PLCB2 | Phosphoinositide phospholipase C. (991 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1199 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa) |
| | RXRA | Retinoid X receptor alpha. (492 aa) |
| | HIF1A | Hypoxia inducible factor 1 subunit alpha. (842 aa) |
| | BMP4 | Bone morphogenetic protein 4. (408 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | ATP2A1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1027 aa) |
| | NCOA2 | Nuclear receptor coactivator. (1475 aa) |
| | ATP1B2 | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | MYH7 | Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa) |
