88 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BGLAP	Osteocalcin; Binds strongly to apatite and calcium. (100 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
	PRKCG	Protein kinase C. (726 aa)
	ARRB2	Arrestin beta 2. (466 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (520 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa)
	GNA11	G protein subunit alpha 11. (354 aa)
	SLC34A2	Solute carrier family 34 member 2. (689 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1169 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	MAFB	MAF bZIP transcription factor B. (323 aa)
	ATF6B	Activating transcription factor 6 beta. (708 aa)
	PTHLH	Parathyroid hormone like hormone. (209 aa)
	CASR	Calcium sensing receptor. (1078 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1079 aa)
	SLC9A3R1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (598 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (606 aa)
	GNA13	G protein subunit alpha 13. (353 aa)
	LOC108534220	Phosphodiesterase. (693 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	RAF1	Uncharacterized protein. (668 aa)
	MEF2A	Myocyte enhancer factor 2A. (511 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (442 aa)
	GATA3	GATA binding protein 3. (444 aa)
	MMP16	Matrix metallopeptidase 16. (607 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	GCM1	Glial cells missing transcription factor 1. (436 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
	VDR	Vitamin D receptor. (477 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	CYP24A1	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (514 aa)
	PTH1R	Parathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
	FGFR1	Fibroblast growth factor receptor. (829 aa)
	TRPV5	Transient receptor potential cation channel subfamily V member 5. (381 aa)
	GNA12	G protein subunit alpha 12. (322 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (604 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (753 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2637 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
	ADCY8	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (657 aa)
	SLC34A1	Solute carrier family 34 member 1. (639 aa)
	CREB3	cAMP responsive element binding protein 3. (370 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
	PDE4A	Phosphodiesterase. (928 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1561 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (317 aa)
	SOST	Sclerostin. (213 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
	MMP15	Matrix metallopeptidase 15. (669 aa)
	MMP25	Matrix metallopeptidase 25. (566 aa)
	MMP13	Matrix metallopeptidase 13. (503 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	AKAP13	A-kinase anchoring protein 13. (2816 aa)
	RXRG	Retinoid X receptor gamma. (463 aa)
	GCM2	Glial cells missing transcription factor 2. (506 aa)
	RXRB	Retinoid X receptor beta. (508 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (503 aa)
	MMP17	Matrix metallopeptidase 17. (598 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
	ARRB1	Arrestin beta 1. (418 aa)
	KL	Klotho. (951 aa)
	GNAS	GNAS complex locus. (1041 aa)
	GNAQ	G protein subunit alpha q. (359 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	PLCB2	Phosphoinositide phospholipase C. (991 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1199 aa)
	RXRA	Retinoid X receptor alpha. (492 aa)
	PDE4B	Phosphodiesterase. (736 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (483 aa)
	PDE4D	Phosphodiesterase. (809 aa)
	PLD1	Phospholipase. (968 aa)
	MMP24	Matrix metallopeptidase 24. (395 aa)
	LOC108541626	Uncharacterized protein. (246 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
	RHOA	Uncharacterized protein. (104 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSRBIP00000035296	ENSRBIP00000024365	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.458
ADCY1	ADCY3	ENSRBIP00000035296	ENSRBIP00000021747	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.944
ADCY1	ADCY5	ENSRBIP00000035296	ENSRBIP00000034265	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.429
ADCY1	ADCY6	ENSRBIP00000035296	ENSRBIP00000004607	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.429
ADCY1	ADCY7	ENSRBIP00000035296	ENSRBIP00000016019	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.488
ADCY1	ADCY8	ENSRBIP00000035296	ENSRBIP00000023627	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.957
ADCY1	ADCY9	ENSRBIP00000035296	ENSRBIP00000021122	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.672
ADCY1	GNAI2	ENSRBIP00000035296	ENSRBIP00000030098	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.940
ADCY1	GNAI3	ENSRBIP00000035296	ENSRBIP00000040755	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.942
ADCY1	GNAS	ENSRBIP00000035296	ENSRBIP00000036792	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.970
ADCY1	LOC108534220	ENSRBIP00000035296	ENSRBIP00000009768	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.722
ADCY1	LOC108541626	ENSRBIP00000035296	ENSRBIP00000041615	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.903
ADCY1	PDE4A	ENSRBIP00000035296	ENSRBIP00000024708	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.736
ADCY1	PDE4B	ENSRBIP00000035296	ENSRBIP00000039798	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.722
ADCY1	PDE4D	ENSRBIP00000035296	ENSRBIP00000041082	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.722
ADCY1	PRKACB	ENSRBIP00000035296	ENSRBIP00000034769	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.939
ADCY1	PRKCA	ENSRBIP00000035296	ENSRBIP00000020301	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.912
ADCY1	PRKCG	ENSRBIP00000035296	ENSRBIP00000001216	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C.	0.910
ADCY2	ADCY1	ENSRBIP00000024365	ENSRBIP00000035296	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.458
ADCY2	ADCY5	ENSRBIP00000024365	ENSRBIP00000034265	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.778