STRINGSTRING
LOC108543755 LOC108543755 MAPK3 MAPK3 FN1 FN1 CRK CRK PIK3R1 PIK3R1 NLRC4 NLRC4 ARF6 ARF6 SRC SRC PIK3R3 PIK3R3 ACTB ACTB MAPK10 MAPK10 RPS6KA2 RPS6KA2 IFNB1 IFNB1 FYB1 FYB1 PKN2 PKN2 LOC108543756 LOC108543756 MAP3K7 MAP3K7 TAB1 TAB1 TLR4 TLR4 CXCL8 CXCL8 NLRP3 NLRP3 MAPK9 MAPK9 CD8B CD8B RPS6KA1 RPS6KA1 ACTR3B ACTR3B SKAP2 SKAP2 LIMK1 LIMK1 ROCK1 ROCK1 MYD88 MYD88 NFATC2 NFATC2 FCGR2A FCGR2A NFATC3 NFATC3 TNF TNF NFKB1 NFKB1 TAB2 TAB2 IRF3 IRF3 PTK2B PTK2B BCAR1 BCAR1 WIPF2 WIPF2 RPS6KA3 RPS6KA3 MAP2K1 MAP2K1 IKBKG IKBKG PXN PXN WASL WASL MAP2K3 MAP2K3 IL1B IL1B PIK3CA PIK3CA RELA RELA CD8A CD8A ITGA5 ITGA5 LCP2 LCP2 ENSRBIP00000020710 ENSRBIP00000020710 MAP2K6 MAP2K6 ITGB1 ITGB1 ACTR3 ACTR3 BAIAP2 BAIAP2 CHUK CHUK ARHGEF7 ARHGEF7 GSK3B GSK3B FOS FOS ARHGEF12 ARHGEF12 MAPK1 MAPK1 IL18 IL18 ZAP70 ZAP70 NFATC1 NFATC1 PKN1 PKN1 IKBKB IKBKB MAPK14 MAPK14 LOC108522153 LOC108522153 CRKL CRKL MAP2K4 MAP2K4 CD4 CD4 TRAF2 TRAF2 CASP1 CASP1 CCL2 CCL2 MAPK13 MAPK13 ACTR2 ACTR2 ITGA4 ITGA4 AKT2 AKT2 AKT3 AKT3 PIP5K1A PIP5K1A MAPK11 MAPK11 VAV1 VAV1 PIK3CD PIK3CD LOC108513176 LOC108513176 TRAF6 TRAF6 MEFV MEFV MAP2K7 MAP2K7 GNAQ GNAQ ARHGEF28 ARHGEF28 WASF2 WASF2 ELMO2 ELMO2 CDC42 CDC42 PIP5K1B PIP5K1B IL2 IL2 PYCARD PYCARD PLCG1 PLCG1 IRAK4 IRAK4 NFKBIA NFKBIA RAC2 RAC2 DOCK1 DOCK1 LAT LAT IL10 IL10 IL6 IL6 RHOA RHOA PIP5K1C PIP5K1C ROCK2 ROCK2 GIT2 GIT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108543755Uncharacterized protein. (191 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
FN1Fibronectin 1. (2477 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
NLRC4NLR family CARD domain containing 4. (1024 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
SRCTyrosine-protein kinase. (627 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
ACTBActin beta. (379 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
IFNB1Interferon beta 1. (187 aa)
FYB1FYN binding protein 1. (839 aa)
PKN2Protein kinase N2. (556 aa)
LOC108543756Uncharacterized protein. (191 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (512 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
CD8BIg-like domain-containing protein. (243 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
ACTR3BActin related protein 3B; Belongs to the actin family. (423 aa)
SKAP2PH domain-containing protein. (181 aa)
LIMK1LIM domain kinase 1. (677 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1341 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
FCGR2AUncharacterized protein. (335 aa)
NFATC3Nuclear factor of activated T cells 3. (1056 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (426 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (906 aa)
WIPF2WAS/WASL interacting protein family member 2. (439 aa)
RPS6KA3Uncharacterized protein. (66 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
PXNPaxillin. (1083 aa)
WASLWASP like actin nucleation promoting factor. (504 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
RELAUncharacterized protein. (282 aa)
CD8ACD8a molecule. (235 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1051 aa)
LCP2Lymphocyte cytosolic protein 2. (531 aa)
ENSRBIP00000020710Ig-like domain-containing protein. (124 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (937 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (368 aa)
BAIAP2BAI1 associated protein 2. (605 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (755 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1536 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
NFATC1Nuclear factor of activated T cells 1. (989 aa)
PKN1Protein kinase N1. (965 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC108522153Ig-like domain-containing protein. (198 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (408 aa)
CD4CD4 molecule. (458 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (404 aa)
CCL2C-C motif chemokine. (99 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
VAV1Vav guanine nucleotide exchange factor 1. (843 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LOC108513176Uncharacterized protein; Belongs to the peptidase C14A family. (406 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
MEFVMEFV innate immuity regulator, pyrin. (784 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (414 aa)
GNAQG protein subunit alpha q. (359 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1685 aa)
WASF2WASP family member 2. (498 aa)
ELMO2Engulfment and cell motility 2. (718 aa)
CDC42Uncharacterized protein. (191 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
PYCARDPYD and CARD domain containing. (195 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (461 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
RAC2Rac family small GTPase 2. (192 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1930 aa)
LATLinker for activation of T cells. (254 aa)
IL10Interleukin 10. (178 aa)
IL6Interleukin 6. (214 aa)
RHOAUncharacterized protein. (104 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (376 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1387 aa)
GIT2GIT ArfGAP 2. (762 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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