STRINGSTRING
TLR2 TLR2 MAPK3 MAPK3 EEF1A2 EEF1A2 JAK1 JAK1 TGFB2 TGFB2 MAP3K7 MAP3K7 TAB1 TAB1 IL12B IL12B TLR4 TLR4 ELK1 ELK1 TGFB1 TGFB1 C3 C3 NCF2 NCF2 EEF1A1 EEF1A1 MYD88 MYD88 FCGR2A FCGR2A TNF TNF CYBA CYBA NFKB1 NFKB1 CR1L CR1L TAB2 TAB2 LOC108512973 LOC108512973 HLA-DQA1 HLA-DQA1 HLA-DQB1 HLA-DQB1 HLA-DRA HLA-DRA IFNGR2 IFNGR2 IL1B IL1B RELA RELA HLA-DPA1 HLA-DPA1 NFKBIB NFKBIB ENSRBIP00000019541 ENSRBIP00000019541 LOC108519884 LOC108519884 ENSRBIP00000020710 ENSRBIP00000020710 ITGB1 ITGB1 IFNGR1 IFNGR1 PTGS2 PTGS2 FOS FOS MAPK1 MAPK1 TGFB3 TGFB3 MAPK14 MAPK14 LOC108522153 LOC108522153 LOC108538696 LOC108538696 LOC108519885 LOC108519885 HLA-DOB HLA-DOB IFNG IFNG IL12A IL12A MAPK13 MAPK13 HLA-DPB1 HLA-DPB1 ITGA4 ITGA4 MAPK11 MAPK11 HLA-DOA HLA-DOA ITGAM ITGAM IL1A IL1A TRAF6 TRAF6 STAT1 STAT1 IRAK4 IRAK4 NFKBIA NFKBIA PTPN6 PTPN6 MARCKSL1 MARCKSL1 IL4 IL4 NCF4 NCF4 IL10 IL10 NOS2 NOS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR2Toll-like receptor. (784 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
EEF1A2Eukaryotic translation elongation factor 1 alpha 2. (604 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (512 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
ELK1ETS domain-containing protein. (428 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
C3Complement C3. (1598 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
EEF1A1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
FCGR2AUncharacterized protein. (335 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CR1LComplement C3b/C4b receptor 1 like. (568 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
LOC108512973Ig-like domain-containing protein. (263 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (254 aa)
HLA-DQB1Ig-like domain-containing protein. (261 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
RELAUncharacterized protein. (282 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
NFKBIBNFKB inhibitor beta. (338 aa)
ENSRBIP00000019541Ig-like domain-containing protein. (264 aa)
LOC108519884Ig-like domain-containing protein. (266 aa)
ENSRBIP00000020710Ig-like domain-containing protein. (124 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (937 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC108522153Ig-like domain-containing protein. (198 aa)
LOC108538696Uncharacterized protein. (351 aa)
LOC108519885Ig-like domain-containing protein. (266 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (159 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (461 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (602 aa)
MARCKSL1MARCKS like 1. (194 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
IL10Interleukin 10. (178 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1126 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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