STRINGSTRING
SERPINE1 SERPINE1 CD3D CD3D TLR2 TLR2 MAPK3 MAPK3 CD247 CD247 PIK3R1 PIK3R1 PIK3R3 PIK3R3 FASLG FASLG TGFB2 TGFB2 MAPK10 MAPK10 GNA11 GNA11 C1QC C1QC C1QB C1QB IFNB1 IFNB1 IL12B IL12B ACE ACE TLR4 TLR4 CXCL8 CXCL8 TGFB1 TGFB1 MAPK9 MAPK9 PLCB1 PLCB1 KNG1 KNG1 CD3G CD3G PPP2R1B PPP2R1B C3 C3 GNA14 GNA14 PPP2R2A PPP2R2A CFLAR CFLAR PPP2R1A PPP2R1A MYD88 MYD88 CD3E CD3E TNF TNF SMAD2 SMAD2 NFKB1 NFKB1 IKBKG IKBKG IFNGR2 IFNGR2 IL1B IL1B PIK3CA PIK3CA RELA RELA PPP2R2C PPP2R2C LOC108524465 LOC108524465 IFNGR1 IFNGR1 TGFBR2 TGFBR2 CHUK CHUK FOS FOS GNA15 GNA15 FADD FADD MAPK1 MAPK1 TGFB3 TGFB3 PPP2R2D PPP2R2D IKBKB IKBKB MAPK14 MAPK14 FAS FAS CALR CALR TLR9 TLR9 MAP2K4 MAP2K4 GNAI2 GNAI2 CCL5 CCL5 IFNG IFNG CCL2 CCL2 IL12A IL12A MAPK13 MAPK13 AKT2 AKT2 TGFBR1 TGFBR1 AKT3 AKT3 MAPK11 MAPK11 PIK3CD PIK3CD ADCY1 ADCY1 TRAF6 TRAF6 GNAS GNAS GNAQ GNAQ PPP2R2B PPP2R2B PLCB2 PLCB2 IL2 IL2 PLCB4 PLCB4 IRAK4 IRAK4 TNFRSF1A TNFRSF1A NFKBIA NFKBIA GNAI3 GNAI3 IL10 IL10 NOS2 NOS2 IL6 IL6 LOC108541626 LOC108541626 CASP8 CASP8 PPP2CA PPP2CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SERPINE1Serpin family E member 1; Belongs to the serpin family. (429 aa)
CD3DCD3d molecule. (171 aa)
TLR2Toll-like receptor. (784 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
CD247CD247 molecule. (165 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
GNA11G protein subunit alpha 11. (354 aa)
C1QCComplement C1q C chain. (245 aa)
C1QBComplement C1q B chain. (253 aa)
IFNB1Interferon beta 1. (187 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
ACEAngiotensin-converting enzyme. (1307 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1079 aa)
KNG1Kininogen 1. (644 aa)
CD3GCD3g molecule. (181 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
C3Complement C3. (1598 aa)
GNA14G protein subunit alpha 14. (355 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
CD3ECD3e molecule. (198 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
RELAUncharacterized protein. (282 aa)
PPP2R2CProtein phosphatase 2 regulatory subunit Bgamma. (282 aa)
LOC108524465C-C motif chemokine. (92 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GNA15G protein subunit alpha 15. (312 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
FASFas cell surface death receptor. (331 aa)
CALRCalreticulin. (417 aa)
TLR9TIR domain-containing protein. (1033 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (408 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CCL5C-C motif chemokine. (91 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (159 aa)
CCL2C-C motif chemokine. (99 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
GNASGNAS complex locus. (1041 aa)
GNAQG protein subunit alpha q. (359 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
PLCB2Phosphoinositide phospholipase C. (991 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1199 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (461 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
GNAI3G protein subunit alpha i3. (354 aa)
IL10Interleukin 10. (178 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1126 aa)
IL6Interleukin 6. (214 aa)
LOC108541626Uncharacterized protein. (246 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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