STRINGSTRING
CD46 CD46 OAS1 OAS1 LOC108524923 LOC108524923 CD3D CD3D LOC108535521 LOC108535521 TLR2 TLR2 CDKN1B CDKN1B PIK3R1 PIK3R1 HSPA1L HSPA1L PIK3R3 PIK3R3 JAK1 JAK1 FASLG FASLG MAPK10 MAPK10 LOC108533297 LOC108533297 LOC108523439 LOC108523439 CBLB CBLB IKBKE IKBKE IFNB1 IFNB1 TLR7 TLR7 MAP3K7 MAP3K7 APAF1 APAF1 IL12B IL12B TLR4 TLR4 MAPK9 MAPK9 OAS3 OAS3 CD3G CD3G RACK1 RACK1 BID BID EIF2AK3 EIF2AK3 MYD88 MYD88 BCL2 BCL2 IFIH1 IFIH1 CD3E CD3E CSNK2A2 CSNK2A2 CD28 CD28 NFKB1 NFKB1 TAB2 TAB2 IRF3 IRF3 CASP9 CASP9 IKBKG IKBKG STAT5B STAT5B CD209 CD209 TP73 TP73 IL2RG IL2RG IL1B IL1B PIK3CA PIK3CA RELA RELA TRADD TRADD CDK4 CDK4 NFKBIB NFKBIB MAVS MAVS TNFAIP3 TNFAIP3 SLAMF1 SLAMF1 EIF2AK2 EIF2AK2 TYK2 TYK2 CHUK CHUK GSK3B GSK3B FOS FOS IFNAR1 IFNAR1 IL2RA IL2RA OAS2 OAS2 EIF2AK4 EIF2AK4 IRF7 IRF7 CCND1 CCND1 FADD FADD CSNK2B CSNK2B JAK3 JAK3 IKBKB IKBKB MX2 MX2 CCND3 CCND3 TP53 TP53 FAS FAS TLR9 TLR9 IL12A IL12A DDX58 DDX58 STAT2 STAT2 AKT2 AKT2 CCNE2 CCNE2 AKT3 AKT3 EIF3H EIF3H PIK3CD PIK3CD BAX BAX IL1A IL1A TRAF6 TRAF6 MSN MSN STAT1 STAT1 BAK1 BAK1 IL2 IL2 IRAK4 IRAK4 NFKBIA NFKBIA CCND2 CCND2 EIF2S1 EIF2S1 IL6 IL6 IL2RB IL2RB BAD BAD MX1 MX1 CDK6 CDK6 TRAF3 TRAF3 IFNAR2 IFNAR2 CASP8 CASP8 HSPA2 HSPA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD46CD46 molecule. (399 aa)
OAS12'-5'-oligoadenylate synthetase 1. (408 aa)
LOC108524923Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CD3DCD3d molecule. (171 aa)
LOC108535521Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TLR2Toll-like receptor. (784 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
LOC108533297Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
LOC108523439Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CBLBCbl proto-oncogene B. (1018 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
IFNB1Interferon beta 1. (187 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1228 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1092 aa)
CD3GCD3g molecule. (181 aa)
RACK1Receptor for activated C kinase 1. (330 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1089 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
IFIH1Interferon induced with helicase C domain 1. (1014 aa)
CD3ECD3e molecule. (198 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
CD28CD28 molecule. (220 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (426 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (372 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
STAT5BSignal transducer and activator of transcription. (768 aa)
CD209CD209 molecule. (356 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
RELAUncharacterized protein. (282 aa)
TRADDTNFRSF1A associated via death domain. (248 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
NFKBIBNFKB inhibitor beta. (338 aa)
MAVSMitochondrial antiviral signaling protein. (539 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (357 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (538 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (553 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
OAS22'-5'-oligoadenylate synthetase 2. (687 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1598 aa)
IRF7Interferon regulatory factor 7. (503 aa)
CCND1Cyclin D1. (156 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
CSNK2BUncharacterized protein. (298 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MX2MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (715 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (286 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
FASFas cell surface death receptor. (331 aa)
TLR9TIR domain-containing protein. (1033 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
DDX58DExD/H-box helicase 58. (914 aa)
STAT2Signal transducer and activator of transcription. (844 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (403 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
EIF3HEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (365 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
MSNMoesin. (577 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (461 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
CCND2Uncharacterized protein; Belongs to the cyclin family. (244 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
IL6Interleukin 6. (214 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
BADBCL2 associated agonist of cell death. (167 aa)
MX1MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (646 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
TRAF3TNF receptor-associated factor. (477 aa)
IFNAR2Uncharacterized protein. (516 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (619 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.