STRINGSTRING
LOC108524923 LOC108524923 LOC108535521 LOC108535521 MAPK3 MAPK3 CCR1 CCR1 CALML3 CALML3 PRKCG PRKCG CRK CRK PIK3R1 PIK3R1 SRC SRC PIK3R3 PIK3R3 PPP3CA PPP3CA JAK1 JAK1 FASLG FASLG PPP3CB PPP3CB LOC108533297 LOC108533297 CREB3L2 CREB3L2 CCR5 CCR5 LOC108523439 LOC108523439 LOC108543093 LOC108543093 GNA11 GNA11 IFNB1 IFNB1 ADCY6 ADCY6 MTOR MTOR CALML4 CALML4 ATF6B ATF6B RHEB RHEB ELK1 ELK1 CXCL8 CXCL8 GNB4 GNB4 PLCB1 PLCB1 ENSRBIP00000007423 ENSRBIP00000007423 B2M B2M IL6R IL6R PTGER4 PTGER4 NFATC4 NFATC4 ITGB3 ITGB3 CALM1 CALM1 BID BID IL1R1 IL1R1 TRAF5 TRAF5 GNA13 GNA13 GNG7 GNG7 ROCK1 ROCK1 NFATC2 NFATC2 GNG13 GNG13 NFATC3 NFATC3 RAF1 RAF1 PPP3CC PPP3CC CXCR4 CXCR4 TNF TNF CREB3L1 CREB3L1 EIF4EBP1 EIF4EBP1 NFKB1 NFKB1 IRF3 IRF3 CASP9 CASP9 PTK2B PTK2B BCAR1 BCAR1 MAP2K1 MAP2K1 IKBKG IKBKG PXN PXN ADCY7 ADCY7 CCR3 CCR3 GRB2 GRB2 ATF4 ATF4 IL10RA IL10RA GNB3 GNB3 ITGAV ITGAV IL1B IL1B PIK3CA PIK3CA RELA RELA GNG4 GNG4 GNG5 GNG5 TRADD TRADD CDK4 CDK4 GNA12 GNA12 GNG11 GNG11 RB1 RB1 PRKCA PRKCA CGAS CGAS IL10RB IL10RB MAP2K6 MAP2K6 LOC108524465 LOC108524465 ADCY9 ADCY9 CX3CL1 CX3CL1 ADCY3 ADCY3 HRAS HRAS GNG2 GNG2 PTGER3 PTGER3 CTNNB1 CTNNB1 ITPR2 ITPR2 STING1 STING1 PTGS2 PTGS2 ITPR1 ITPR1 HLA-F HLA-F TSC1 TSC1 ADCY8 ADCY8 CREB3 CREB3 CHUK CHUK GSK3B GSK3B ADCY2 ADCY2 ARHGEF11 ARHGEF11 PDIA3 PDIA3 ARHGEF12 ARHGEF12 HLA-E HLA-E CCND1 CCND1 GNG3 GNG3 FADD FADD MAPK1 MAPK1 KRAS KRAS NFATC1 NFATC1 IKBKB IKBKB MAPK14 MAPK14 TP53 TP53 LOC108541410 LOC108541410 FAS FAS CALR CALR CRKL CRKL TAP1 TAP1 GNAI2 GNAI2 AKAP13 AKAP13 CCL5 CCL5 GNG12 GNG12 TRAF2 TRAF2 CREB5 CREB5 PTGER1 PTGER1 GNB1 GNB1 CCL2 CCL2 E2F2 E2F2 TSC2 TSC2 TAPBP TAPBP GNG8 GNG8 MAPK13 MAPK13 CALM3 CALM3 CXCL12 CXCL12 MYC MYC SOS1 SOS1 CREB1 CREB1 AKT2 AKT2 ADCY5 ADCY5 AKT3 AKT3 MAPK11 MAPK11 PRKACB PRKACB GNB5 GNB5 PIK3CD PIK3CD ADCY1 ADCY1 BAX BAX SOS2 SOS2 GNAS GNAS GNAQ GNAQ BAK1 BAK1 EGFR EGFR PDGFRA PDGFRA PLCB2 PLCB2 TAP2 TAP2 PLCB4 PLCB4 LOC108528436 LOC108528436 TNFRSF1A TNFRSF1A NFKBIA NFKBIA NRAS NRAS RAC2 RAC2 E2F3 E2F3 GNAI3 GNAI3 CREB3L3 CREB3L3 RIPK1 RIPK1 IL6 IL6 LOC108541626 LOC108541626 ITPR3 ITPR3 RHOA RHOA PTGER2 PTGER2 CDK6 CDK6 CASP8 CASP8 ROCK2 ROCK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108524923Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC108535521Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PRKCGProtein kinase C. (726 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SRCTyrosine-protein kinase. (627 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PPP3CASerine/threonine-protein phosphatase. (310 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
LOC108533297Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
LOC108523439Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC108543093Ig-like domain-containing protein; Belongs to the MHC class I family. (378 aa)
GNA11G protein subunit alpha 11. (354 aa)
IFNB1Interferon beta 1. (187 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1169 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
CALML4Calmodulin like 4. (192 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
RHEBRas homolog, mTORC1 binding. (183 aa)
ELK1ETS domain-containing protein. (428 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
GNB4G protein subunit beta 4. (340 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1079 aa)
ENSRBIP00000007423Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
IL6RInterleukin 6 receptor. (499 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
NFATC4Nuclear factor of activated T cells 4. (909 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa)
IL1R1Interleukin 1 receptor type 1. (568 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (563 aa)
GNA13G protein subunit alpha 13. (353 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1341 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
GNG13G protein subunit gamma 13. (67 aa)
NFATC3Nuclear factor of activated T cells 3. (1056 aa)
RAF1Uncharacterized protein. (668 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (415 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (442 aa)
EIF4EBP1Uncharacterized protein. (118 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (426 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (372 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (906 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
PXNPaxillin. (1083 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ATF4Activating transcription factor 4. (351 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
GNB3G protein subunit beta 3. (340 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
RELAUncharacterized protein. (282 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
TRADDTNFRSF1A associated via death domain. (248 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
GNA12G protein subunit alpha 12. (322 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
RB1RB transcriptional corepressor 1. (815 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (604 aa)
CGASCyclic GMP-AMP synthase. (527 aa)
IL10RBInterleukin 10 receptor subunit beta. (325 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LOC108524465C-C motif chemokine. (92 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (407 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (102 aa)
PTGER3Prostaglandin E receptor 3. (418 aa)
CTNNB1Catenin beta 1. (781 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2637 aa)
STING1Transmembrane protein 173. (379 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
HLA-FMajor histocompatibility complex, class I, F; Belongs to the MHC class I family. (369 aa)
TSC1TSC complex subunit 1. (1164 aa)
ADCY8Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (657 aa)
CREB3cAMP responsive element binding protein 3. (370 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1561 aa)
PDIA3Protein disulfide-isomerase. (441 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1536 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (359 aa)
CCND1Cyclin D1. (156 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NFATC1Nuclear factor of activated T cells 1. (989 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
LOC108541410SCY domain-containing protein. (102 aa)
FASFas cell surface death receptor. (331 aa)
CALRCalreticulin. (417 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (808 aa)
GNAI2G protein subunit alpha i2. (355 aa)
AKAP13A-kinase anchoring protein 13. (2816 aa)
CCL5C-C motif chemokine. (91 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (503 aa)
PTGER1Prostaglandin E receptor 1. (227 aa)
GNB1G protein subunit beta 1. (340 aa)
CCL2C-C motif chemokine. (99 aa)
E2F2E2F transcription factor 2. (437 aa)
TSC2TSC complex subunit 2. (1805 aa)
TAPBPTAP binding protein. (504 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (163 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1293 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNB5G protein subunit beta 5. (403 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1268 aa)
GNASGNAS complex locus. (1041 aa)
GNAQG protein subunit alpha q. (359 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PLCB2Phosphoinositide phospholipase C. (991 aa)
TAP2Transporter 2, ATP binding cassette subfamily B member. (723 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1199 aa)
LOC108528436Ig-like domain-containing protein; Belongs to the MHC class I family. (394 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAC2Rac family small GTPase 2. (192 aa)
E2F3E2F transcription factor 3. (465 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (483 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (672 aa)
IL6Interleukin 6. (214 aa)
LOC108541626Uncharacterized protein. (246 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
RHOAUncharacterized protein. (104 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (358 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1387 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
Server load: low (16%) [HD]