STRINGSTRING
SRF SRF CD3D CD3D MAPK3 MAPK3 IL15 IL15 MAP3K1 MAP3K1 PIK3R1 PIK3R1 ESPL1 ESPL1 TNFRSF13C TNFRSF13C SPI1 SPI1 PIK3R3 PIK3R3 PPP3CA PPP3CA LOC108512004 LOC108512004 JAK1 JAK1 PPP3CB PPP3CB TGFB2 TGFB2 CDC20 CDC20 MAPK10 MAPK10 CREB3L2 CREB3L2 IL15RA IL15RA MSX1 MSX1 EGR1 EGR1 LOC108543093 LOC108543093 ADCY6 ADCY6 TBP TBP ETS1 ETS1 GPS2 GPS2 DLG1 DLG1 ATF6B ATF6B SLC25A31 SLC25A31 KAT2A KAT2A ELK1 ELK1 TGFB1 TGFB1 MAPK9 MAPK9 CD3G CD3G CDC16 CDC16 RANBP3 RANBP3 NFKB2 NFKB2 B2M B2M NFATC4 NFATC4 IL1R1 IL1R1 VDAC1 VDAC1 ANAPC10 ANAPC10 NFATC2 NFATC2 NFATC3 NFATC3 PPP3CC PPP3CC CD3E CD3E TNF TNF CREB3L1 CREB3L1 MAD1L1 MAD1L1 TCF3 TCF3 ELK4 ELK4 SMAD2 SMAD2 NFKB1 NFKB1 BUB3 BUB3 TBPL1 TBPL1 VAC14 VAC14 MAP2K1 MAP2K1 IKBKG IKBKG LOC108512973 LOC108512973 HLA-DQA1 HLA-DQA1 HLA-DQB1 HLA-DQB1 ADCY7 ADCY7 CRTC3 CRTC3 HLA-DRA HLA-DRA STAT5B STAT5B TERT TERT LTBR LTBR ATF4 ATF4 SLC25A4 SLC25A4 IL2RG IL2RG VDAC2 VDAC2 PIK3CA PIK3CA RELA RELA LTA LTA HLA-DPA1 HLA-DPA1 SMAD4 SMAD4 CDK4 CDK4 ENSRBIP00000019541 ENSRBIP00000019541 ETS2 ETS2 RB1 RB1 SLC2A1 SLC2A1 CCNB2 CCNB2 ATM ATM LOC108519884 LOC108519884 CRTC2 CRTC2 ADCY9 ADCY9 MSX2 MSX2 ADCY3 ADCY3 HRAS HRAS MAD2L1 MAD2L1 NRP1 NRP1 FOSL1 FOSL1 TGFBR2 TGFBR2 HLA-F HLA-F ADCY8 ADCY8 CDC23 CDC23 CREB3 CREB3 CHUK CHUK MAP3K14 MAP3K14 CCNA1 CCNA1 ADCY2 ADCY2 MMP7 MMP7 FOS FOS HLA-E HLA-E IL2RA IL2RA ITGAL ITGAL CCND1 CCND1 CDKN2C CDKN2C SLC25A6 SLC25A6 MAPK1 MAPK1 TGFB3 TGFB3 ANAPC5 ANAPC5 KRAS KRAS ATR ATR FDPS FDPS NFATC1 NFATC1 CSF2 CSF2 JAK3 JAK3 IKBKB IKBKB CCND3 CCND3 VDAC3 VDAC3 TP53 TP53 KAT5 KAT5 ZFP36 ZFP36 CALR CALR LOC108519885 LOC108519885 MAP2K4 MAP2K4 CD4 CD4 HLA-DOB HLA-DOB CREBBP CREBBP RELB RELB TSPO2 TSPO2 CREB5 CREB5 MAP3K3 MAP3K3 ICAM1 ICAM1 E2F2 E2F2 RANBP1 RANBP1 HLA-DPB1 HLA-DPB1 MYC MYC EP300 EP300 CREB1 CREB1 AKT2 AKT2 CCNE2 CCNE2 POLB POLB TGFBR1 TGFBR1 NFYB NFYB ADCY5 ADCY5 AKT3 AKT3 ANAPC2 ANAPC2 PRKACB PRKACB PTEN PTEN PIK3CD PIK3CD HLA-DOA HLA-DOA ADCY1 ADCY1 CD40 CD40 BAX BAX CCNA2 CCNA2 IL1R2 IL1R2 IL2 IL2 BUB1B BUB1B LOC108528436 LOC108528436 TNFRSF1A TNFRSF1A NFKBIA NFKBIA NRAS NRAS CCND2 CCND2 TBPL2 TBPL2 E2F3 E2F3 CREB3L3 CREB3L3 ANAPC4 ANAPC4 TRRAP TRRAP IL6 IL6 IL2RB IL2RB TLN1 TLN1 ANAPC1 ANAPC1 ANAPC7 ANAPC7 TLN2 TLN2 TSPO TSPO CDC26 CDC26
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRFSerum response factor. (508 aa)
CD3DCD3d molecule. (171 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1374 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2120 aa)
TNFRSF13CTNF receptor superfamily member 13C. (140 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PPP3CASerine/threonine-protein phosphatase. (310 aa)
LOC108512004Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CDC20Cell division cycle 20. (499 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
IL15RAInterleukin 15 receptor subunit alpha. (352 aa)
MSX1Msh homeobox 1. (303 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa)
LOC108543093Ig-like domain-containing protein; Belongs to the MHC class I family. (378 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1169 aa)
TBPTATA-box binding protein. (338 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
GPS2G protein pathway suppressor 2. (327 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (861 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (314 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
ELK1ETS domain-containing protein. (428 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
CD3GCD3g molecule. (181 aa)
CDC16Cell division cycle 16. (620 aa)
RANBP3RAN binding protein 3. (591 aa)
NFKB2Nuclear factor kappa B subunit 2. (906 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
NFATC4Nuclear factor of activated T cells 4. (909 aa)
IL1R1Interleukin 1 receptor type 1. (568 aa)
VDAC1Voltage dependent anion channel 1. (299 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (184 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
NFATC3Nuclear factor of activated T cells 3. (1056 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
CD3ECD3e molecule. (198 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (442 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (766 aa)
TCF3Transcription factor 3. (654 aa)
ELK4ETS transcription factor ELK4. (431 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
BUB3WD_REPEATS_REGION domain-containing protein. (328 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
VAC14VAC14 component of PIKFYVE complex. (782 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
LOC108512973Ig-like domain-containing protein. (263 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (254 aa)
HLA-DQB1Ig-like domain-containing protein. (261 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
CRTC3CREB regulated transcription coactivator 3. (603 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
STAT5BSignal transducer and activator of transcription. (768 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1167 aa)
LTBRLymphotoxin beta receptor. (370 aa)
ATF4Activating transcription factor 4. (351 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
VDAC2Voltage dependent anion channel 2. (308 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
RELAUncharacterized protein. (282 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ENSRBIP00000019541Ig-like domain-containing protein. (264 aa)
ETS2Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa)
RB1RB transcriptional corepressor 1. (815 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
CCNB2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (398 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3026 aa)
LOC108519884Ig-like domain-containing protein. (266 aa)
CRTC2CREB regulated transcription coactivator 2. (699 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
MSX2Msh homeobox 2. (267 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAD2L1HORMA domain-containing protein. (205 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
HLA-FMajor histocompatibility complex, class I, F; Belongs to the MHC class I family. (369 aa)
ADCY8Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (657 aa)
CDC23Cell division cycle 23. (597 aa)
CREB3cAMP responsive element binding protein 3. (370 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
MMP7Matrix metallopeptidase 7. (270 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (359 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1155 aa)
CCND1Cyclin D1. (156 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
SLC25A6Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2578 aa)
FDPSFarnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (419 aa)
NFATC1Nuclear factor of activated T cells 1. (989 aa)
CSF2Colony stimulating factor 2. (144 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (286 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
ZFP36ZFP36 ring finger protein. (332 aa)
CALRCalreticulin. (417 aa)
LOC108519885Ig-like domain-containing protein. (266 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (408 aa)
CD4CD4 molecule. (458 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
CREBBPCREB binding protein. (2422 aa)
RELBRELB proto-oncogene, NF-kB subunit. (541 aa)
TSPO2Translocator protein 2. (170 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (503 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
E2F2E2F transcription factor 2. (437 aa)
RANBP1RAN binding protein 1. (278 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
EP300E1A binding protein p300. (2296 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (403 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
NFYBCBFD_NFYB_HMF domain-containing protein. (208 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PTENUncharacterized protein. (555 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
CD40CD40 molecule. (278 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
IL1R2Interleukin 1 receptor type 2. (397 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
BUB1BBUB1 N-terminal domain-containing protein. (1050 aa)
LOC108528436Ig-like domain-containing protein; Belongs to the MHC class I family. (394 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CCND2Uncharacterized protein; Belongs to the cyclin family. (244 aa)
TBPL2TATA-box binding protein like 2. (375 aa)
E2F3E2F transcription factor 3. (465 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (483 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (807 aa)
TRRAPTransformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3824 aa)
IL6Interleukin 6. (214 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
TLN1Talin 1. (2562 aa)
ANAPC1Anaphase promoting complex subunit 1. (1944 aa)
ANAPC7Anaphase promoting complex subunit 7. (498 aa)
TLN2Talin 2. (2536 aa)
TSPOTranslocator protein. (169 aa)
CDC26Cell division cycle 26. (85 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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