STRINGSTRING
LOC108524923 LOC108524923 LOC108535521 LOC108535521 MAPK3 MAPK3 RPS27A RPS27A CCR1 CCR1 CALML3 CALML3 TCF7L2 TCF7L2 ENSRBIP00000001317 ENSRBIP00000001317 PIK3R1 PIK3R1 SRC SRC PIK3R3 PIK3R3 PPP3CA PPP3CA HCK HCK JAK1 JAK1 PPP3CB PPP3CB MAPK10 MAPK10 LOC108533297 LOC108533297 CCR5 CCR5 LOC108523439 LOC108523439 PREX1 PREX1 LOC108543093 LOC108543093 IKBKE IKBKE IFNB1 IFNB1 MTOR MTOR CALML4 CALML4 LOC108540530 LOC108540530 CXCL8 CXCL8 GNB4 GNB4 MAPK9 MAPK9 ENSRBIP00000007423 ENSRBIP00000007423 GABARAP GABARAP TLR3 TLR3 C3 C3 UBA52 UBA52 NFATC4 NFATC4 CALM1 CALM1 BID BID LEF1 LEF1 GNG7 GNG7 NFATC2 NFATC2 GNG13 GNG13 ATG3 ATG3 NFATC3 NFATC3 RAF1 RAF1 PPP3CC PPP3CC TCF7 TCF7 TCF7L1 TCF7L1 NFKB1 NFKB1 IRF3 IRF3 CASP9 CASP9 PLCG2 PLCG2 CCR4 CCR4 PIK3R6 PIK3R6 MAP2K1 MAP2K1 IKBKG IKBKG CCR3 CCR3 PIK3C3 PIK3C3 PDGFB PDGFB CLEC2B CLEC2B CD86 CD86 GNB3 GNB3 PIK3CA PIK3CA RELA RELA LOC108513563 LOC108513563 GNG4 GNG4 GNG5 GNG5 TRADD TRADD CDK4 CDK4 GNG11 GNG11 RB1 RB1 ATG14 ATG14 MAP2K6 MAP2K6 RCAN1 RCAN1 EIF2AK2 EIF2AK2 BECN1 BECN1 HRAS HRAS GNG2 GNG2 IFNGR1 IFNGR1 CTNNB1 CTNNB1 ITPR2 ITPR2 SYK SYK PTGS2 PTGS2 TYK2 TYK2 ITPR1 ITPR1 HLA-F HLA-F CHUK CHUK GSK3B GSK3B LOC108523516 LOC108523516 FOS FOS HLA-E HLA-E IFNAR1 IFNAR1 IRF7 IRF7 CCND1 CCND1 GNG3 GNG3 FADD FADD MAPK1 MAPK1 KRAS KRAS NFATC1 NFATC1 CSF2 CSF2 IKBKB IKBKB CXCL2 CXCL2 MAPK14 MAPK14 GABARAPL1 GABARAPL1 TP53 TP53 ZFP36 ZFP36 FAS FAS MAP2K4 MAP2K4 CREBBP CREBBP IL6ST IL6ST GNG12 GNG12 TRAF2 TRAF2 GABARAPL2 GABARAPL2 GNB1 GNB1 ICAM1 ICAM1 E2F2 E2F2 GNG8 GNG8 MAPK13 MAPK13 CALM3 CALM3 MYC MYC LOC108516810 LOC108516810 STAT2 STAT2 EP300 EP300 CREB1 CREB1 AKT2 AKT2 AKT3 AKT3 MAPKAPK2 MAPKAPK2 MAPK11 MAPK11 GNB5 GNB5 PIK3CD PIK3CD BAX BAX MICB MICB LYN LYN MAP2K7 MAP2K7 STAT1 STAT1 BAK1 BAK1 PLCG1 PLCG1 LOC108528436 LOC108528436 HIF1A HIF1A TNFRSF1A TNFRSF1A NFKBIA NFKBIA NRAS NRAS LOC108539235 LOC108539235 ANGPT2 ANGPT2 E2F3 E2F3 PIK3CG PIK3CG IL6 IL6 ITPR3 ITPR3 CDK6 CDK6 TRAF3 TRAF3 IFNAR2 IFNAR2 CASP8 CASP8 PIK3R5 PIK3R5
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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LOC108524923Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC108535521Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
TCF7L2HMG box domain-containing protein. (376 aa)
ENSRBIP00000001317Ubiquitin-like domain-containing protein. (155 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SRCTyrosine-protein kinase. (627 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PPP3CASerine/threonine-protein phosphatase. (310 aa)
HCKTyrosine-protein kinase. (517 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
LOC108533297Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
LOC108523439Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1629 aa)
LOC108543093Ig-like domain-containing protein; Belongs to the MHC class I family. (378 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
IFNB1Interferon beta 1. (187 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
CALML4Calmodulin like 4. (192 aa)
LOC108540530Ubiquitin A-52 residue ribosomal protein fusion product 1. (77 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
GNB4G protein subunit beta 4. (340 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
ENSRBIP00000007423Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
GABARAPUncharacterized protein. (119 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (903 aa)
C3Complement C3. (1598 aa)
UBA52Ubiquitin-like domain-containing protein. (232 aa)
NFATC4Nuclear factor of activated T cells 4. (909 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa)
LEF1Lymphoid enhancer binding factor 1. (398 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
GNG13G protein subunit gamma 13. (67 aa)
ATG3Autophagy-related protein 3. (314 aa)
NFATC3Nuclear factor of activated T cells 3. (1056 aa)
RAF1Uncharacterized protein. (668 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
TCF7Transcription factor 7. (399 aa)
TCF7L1Transcription factor 7 like 1. (440 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (426 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (372 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (911 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (237 aa)
CLEC2BC-type lectin domain family 2 member B. (151 aa)
CD86CD86 molecule. (329 aa)
GNB3G protein subunit beta 3. (340 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
RELAUncharacterized protein. (282 aa)
LOC108513563C-X-C motif chemokine. (103 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
TRADDTNFRSF1A associated via death domain. (248 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
RB1RB transcriptional corepressor 1. (815 aa)
ATG14Autophagy related 14. (510 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
RCAN1Regulator of calcineurin 1. (255 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (538 aa)
BECN1Beclin 1. (450 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (102 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
CTNNB1Catenin beta 1. (781 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2637 aa)
SYKUncharacterized protein. (331 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
HLA-FMajor histocompatibility complex, class I, F; Belongs to the MHC class I family. (369 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
LOC108523516C-X-C motif chemokine. (107 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (359 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (553 aa)
IRF7Interferon regulatory factor 7. (503 aa)
CCND1Cyclin D1. (156 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NFATC1Nuclear factor of activated T cells 1. (989 aa)
CSF2Colony stimulating factor 2. (144 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
CXCL2C-X-C motif chemokine. (107 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GABARAPL1GABA type A receptor associated protein like 1. (146 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
ZFP36ZFP36 ring finger protein. (332 aa)
FASFas cell surface death receptor. (331 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (408 aa)
CREBBPCREB binding protein. (2422 aa)
IL6STUncharacterized protein. (330 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
GABARAPL2GABA type A receptor associated protein like 2. (124 aa)
GNB1G protein subunit beta 1. (340 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
E2F2E2F transcription factor 2. (437 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (163 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
LOC108516810Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (330 aa)
STAT2Signal transducer and activator of transcription. (844 aa)
EP300E1A binding protein p300. (2296 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
MAPKAPK2MAPK activated protein kinase 2. (392 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
GNB5G protein subunit beta 5. (403 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
MICBIg-like domain-containing protein. (250 aa)
LYNTyrosine-protein kinase. (512 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (414 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
LOC108528436Ig-like domain-containing protein; Belongs to the MHC class I family. (394 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LOC108539235C-X-C motif chemokine. (100 aa)
ANGPT2Angiopoietin 2. (510 aa)
E2F3E2F transcription factor 3. (465 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
IL6Interleukin 6. (214 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
TRAF3TNF receptor-associated factor. (477 aa)
IFNAR2Uncharacterized protein. (516 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (879 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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