STRINGSTRING
OAS1 OAS1 LOC108524923 LOC108524923 CD3D CD3D LOC108535521 LOC108535521 TLR2 TLR2 CD247 CD247 CDKN1B CDKN1B PSMD2 PSMD2 PIK3R1 PIK3R1 PIK3R3 PIK3R3 JAK1 JAK1 ENTPD1 ENTPD1 MAPK10 MAPK10 LOC108533297 LOC108533297 FCER2 FCER2 LOC108523439 LOC108523439 LOC108543093 LOC108543093 IKBKE IKBKE IFNB1 IFNB1 MAP3K7 MAP3K7 APAF1 APAF1 TAB1 TAB1 MAPK9 MAPK9 OAS3 OAS3 CD3G CD3G PSMC1 PSMC1 ENTPD3 ENTPD3 NFKB2 NFKB2 B2M B2M BID BID TRAF5 TRAF5 VIM VIM MYD88 MYD88 PSMC5 PSMC5 BCL2 BCL2 CD3E CD3E TNF TNF PSMD1 PSMD1 ENTPD8 ENTPD8 BCL2L11 BCL2L11 NFKB1 NFKB1 TAB2 TAB2 IRF3 IRF3 CASP9 CASP9 PLCG2 PLCG2 PSMD4 PSMD4 IKBKG IKBKG LOC108512973 LOC108512973 PSMD11 PSMD11 HLA-DQA1 HLA-DQA1 HLA-DQB1 HLA-DQB1 LOC108527145 LOC108527145 PSMD8 PSMD8 HLA-DRA HLA-DRA MAP2K3 MAP2K3 PIK3CA PIK3CA PSMC3 PSMC3 RELA RELA HLA-DPA1 HLA-DPA1 TRADD TRADD CDK4 CDK4 NFKBIB NFKBIB ENSRBIP00000019541 ENSRBIP00000019541 MAVS MAVS RB1 RB1 TNFAIP3 TNFAIP3 LOC108519884 LOC108519884 ENSRBIP00000020710 ENSRBIP00000020710 MAP2K6 MAP2K6 EIF2AK2 EIF2AK2 HDAC1 HDAC1 CD44 CD44 GADD45B GADD45B SYK SYK TYK2 TYK2 HLA-F HLA-F CHUK CHUK HDAC2 HDAC2 MAP3K14 MAP3K14 CCNA1 CCNA1 DDB2 DDB2 PSMD14 PSMD14 GADD45G GADD45G PDIA3 PDIA3 HLA-E HLA-E IFNAR1 IFNAR1 OAS2 OAS2 IRF7 IRF7 ITGAL ITGAL CCND1 CCND1 FADD FADD USP7 USP7 POLK POLK SAP30 SAP30 JAK3 JAK3 IKBKB IKBKB MAPK14 MAPK14 PSMC2 PSMC2 CCND3 CCND3 LOC108522153 LOC108522153 TP53 TP53 FAS FAS NCOR2 NCOR2 CXCL10 CXCL10 CALR CALR LOC108519885 LOC108519885 TAP1 TAP1 MAP2K4 MAP2K4 ISG15 ISG15 HLA-DOB HLA-DOB TRAF2 TRAF2 SKP2 SKP2 RELB RELB PSMC6 PSMC6 ICAM1 ICAM1 E2F2 E2F2 TAPBP TAPBP MAPK13 MAPK13 DDX58 DDX58 RBPJ RBPJ HLA-DPB1 HLA-DPB1 MYC MYC LOC108516810 LOC108516810 SEM1-2 SEM1-2 STAT2 STAT2 SAP30L SAP30L AKT2 AKT2 CCNE2 CCNE2 AKT3 AKT3 MAPK11 MAPK11 RUNX3 RUNX3 PIK3CD PIK3CD HLA-DOA HLA-DOA PSMC4 PSMC4 CD40 CD40 BAX BAX TRAF6 TRAF6 SNW1 SNW1 LYN LYN CCNA2 CCNA2 MAP2K7 MAP2K7 STAT1 STAT1 BAK1 BAK1 RBPJL RBPJL TAP2 TAP2 IRAK4 IRAK4 GADD45A GADD45A LOC108528436 LOC108528436 NFKBIA NFKBIA CCND2 CCND2 PSMD3 PSMD3 E2F3 E2F3 PSMD7 PSMD7 CD19 CD19 CR2 CR2 RIPK1 RIPK1 IL6 IL6 CD58 CD58 BLNK BLNK CDK6 CDK6 TRAF3 TRAF3 BTK BTK IFNAR2 IFNAR2 CASP8 CASP8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OAS12'-5'-oligoadenylate synthetase 1. (408 aa)
LOC108524923Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CD3DCD3d molecule. (171 aa)
LOC108535521Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TLR2Toll-like receptor. (784 aa)
CD247CD247 molecule. (165 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
ENTPD1Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (522 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
LOC108533297Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
FCER2Fc fragment of IgE receptor II. (321 aa)
LOC108523439Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC108543093Ig-like domain-containing protein; Belongs to the MHC class I family. (378 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
IFNB1Interferon beta 1. (187 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1228 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (512 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1092 aa)
CD3GCD3g molecule. (181 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
ENTPD3Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (529 aa)
NFKB2Nuclear factor kappa B subunit 2. (906 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (563 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CD3ECD3e molecule. (198 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (939 aa)
ENTPD8Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (499 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (426 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (372 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (380 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
LOC108512973Ig-like domain-containing protein. (263 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (254 aa)
HLA-DQB1Ig-like domain-containing protein. (261 aa)
LOC108527145Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (469 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa)
RELAUncharacterized protein. (282 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
TRADDTNFRSF1A associated via death domain. (248 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
NFKBIBNFKB inhibitor beta. (338 aa)
ENSRBIP00000019541Ig-like domain-containing protein. (264 aa)
MAVSMitochondrial antiviral signaling protein. (539 aa)
RB1RB transcriptional corepressor 1. (815 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
LOC108519884Ig-like domain-containing protein. (266 aa)
ENSRBIP00000020710Ig-like domain-containing protein. (124 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (538 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
CD44CD44 molecule (Indian blood group). (742 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
SYKUncharacterized protein. (331 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
HLA-FMajor histocompatibility complex, class I, F; Belongs to the MHC class I family. (369 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (309 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
PDIA3Protein disulfide-isomerase. (441 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (359 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (553 aa)
OAS22'-5'-oligoadenylate synthetase 2. (687 aa)
IRF7Interferon regulatory factor 7. (503 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1155 aa)
CCND1Cyclin D1. (156 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
USP7Uncharacterized protein; Belongs to the peptidase C19 family. (1105 aa)
POLKDNA polymerase kappa. (866 aa)
SAP30Sin3A associated protein 30. (184 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (465 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (286 aa)
LOC108522153Ig-like domain-containing protein. (198 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
FASFas cell surface death receptor. (331 aa)
NCOR2Nuclear receptor corepressor 2. (2488 aa)
CXCL10C-X-C motif chemokine. (98 aa)
CALRCalreticulin. (417 aa)
LOC108519885Ig-like domain-containing protein. (266 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (808 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (408 aa)
ISG15ISG15 ubiquitin like modifier. (167 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
RELBRELB proto-oncogene, NF-kB subunit. (541 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
E2F2E2F transcription factor 2. (437 aa)
TAPBPTAP binding protein. (504 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
DDX58DExD/H-box helicase 58. (914 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (531 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
LOC108516810Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (330 aa)
SEM1-2Uncharacterized protein. (89 aa)
STAT2Signal transducer and activator of transcription. (844 aa)
SAP30LSAP30 like. (247 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (403 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (421 aa)
CD40CD40 molecule. (278 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
SNW1SKIP_SNW domain-containing protein. (536 aa)
LYNTyrosine-protein kinase. (512 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (414 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (522 aa)
TAP2Transporter 2, ATP binding cassette subfamily B member. (723 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (461 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
LOC108528436Ig-like domain-containing protein; Belongs to the MHC class I family. (394 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
CCND2Uncharacterized protein; Belongs to the cyclin family. (244 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
E2F3E2F transcription factor 3. (465 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
CD19CD19 molecule. (557 aa)
CR2Complement C3d receptor 2. (1093 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (672 aa)
IL6Interleukin 6. (214 aa)
CD58CD58 molecule. (250 aa)
BLNKB cell linker. (456 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
TRAF3TNF receptor-associated factor. (477 aa)
BTKTyrosine-protein kinase. (673 aa)
IFNAR2Uncharacterized protein. (516 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
Server load: low (20%) [HD]