(57 nodes) Renal cell carcinoma network (Rhinopithecus bieti)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PAK5	Non-specific serine/threonine protein kinase. (719 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
	CRK	CRK proto-oncogene, adaptor protein. (304 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	PIK3R3	Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
	PAK6	Non-specific serine/threonine protein kinase. (681 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	PAK4	Non-specific serine/threonine protein kinase. (593 aa)
	ELOB	Ubiquitin-like domain-containing protein. (195 aa)
	ARNT2	Aryl hydrocarbon receptor nuclear translocator 2. (723 aa)
	ETS1	ETS proto-oncogene 1, transcription factor. (485 aa)
	RAP1B	Uncharacterized protein. (184 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (606 aa)
	EGLN2	Egl-9 family hypoxia inducible factor 2. (405 aa)
	RAF1	Uncharacterized protein. (668 aa)
	LOC108531561	Ubiquitin-like domain-containing protein. (118 aa)
	TGFA	Transforming growth factor alpha. (166 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	FLCN	Folliculin. (579 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (237 aa)
	EPAS1	Endothelial PAS domain protein 1. (865 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	FH	Fumarate hydratase. (451 aa)
	LOC108522676	Protein kinase domain-containing protein. (299 aa)
	SLC2A1	Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
	PAK1	Non-specific serine/threonine protein kinase. (555 aa)
	VHL	Von Hippel-Lindau tumor suppressor. (213 aa)
	ENSRBIP00000021372	Lyase_1 domain-containing protein. (175 aa)
	PAK2	Non-specific serine/threonine protein kinase. (539 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (753 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	TFE3	Transcription factor binding to IGHM enhancer 3. (575 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	ELOC	Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
	CREBBP	CREB binding protein. (2422 aa)
	GAB1	GRB2 associated binding protein 1. (722 aa)
	EGLN3	Egl-9 family hypoxia inducible factor 3. (239 aa)
	EP300	E1A binding protein p300. (2296 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1293 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1383 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	AKT3	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1268 aa)
	CDC42	Uncharacterized protein. (191 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (842 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
	ARNT	Aryl hydrocarbon receptor nuclear translocator. (789 aa)
	RBX1	Ring-box 1. (108 aa)
	BAD	BCL2 associated agonist of cell death. (167 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT2	AKT3	ENSRBIP00000034007	ENSRBIP00000034274	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	0.939
AKT2	BAD	ENSRBIP00000034007	ENSRBIP00000041804	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 associated agonist of cell death.	0.952
AKT2	MAPK1	ENSRBIP00000034007	ENSRBIP00000026426	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.932
AKT2	MAPK3	ENSRBIP00000034007	ENSRBIP00000000532	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.940
AKT2	PIK3CA	ENSRBIP00000034007	ENSRBIP00000017817	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.967
AKT2	PIK3CD	ENSRBIP00000034007	ENSRBIP00000035123	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.954
AKT2	PIK3R1	ENSRBIP00000034007	ENSRBIP00000001603	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.960
AKT2	PIK3R3	ENSRBIP00000034007	ENSRBIP00000002180	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 3.	0.948
AKT2	RAF1	ENSRBIP00000034007	ENSRBIP00000010874	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.926
AKT3	AKT2	ENSRBIP00000034274	ENSRBIP00000034007	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.939
AKT3	BAD	ENSRBIP00000034274	ENSRBIP00000041804	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	BCL2 associated agonist of cell death.	0.952
AKT3	LOC108522676	ENSRBIP00000034274	ENSRBIP00000018088	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.410
AKT3	MAPK1	ENSRBIP00000034274	ENSRBIP00000026426	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.934
AKT3	MAPK3	ENSRBIP00000034274	ENSRBIP00000000532	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.936
AKT3	PAK1	ENSRBIP00000034274	ENSRBIP00000020723	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.404
AKT3	PIK3CA	ENSRBIP00000034274	ENSRBIP00000017817	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.968
AKT3	PIK3CD	ENSRBIP00000034274	ENSRBIP00000035123	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.954
AKT3	PIK3R1	ENSRBIP00000034274	ENSRBIP00000001603	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.960
AKT3	PIK3R3	ENSRBIP00000034274	ENSRBIP00000002180	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 3.	0.955
AKT3	RAF1	ENSRBIP00000034274	ENSRBIP00000010874	AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.926