STRINGSTRING
BRCA2 BRCA2 MAPK3 MAPK3 PIK3R1 PIK3R1 PIK3R3 PIK3R3 JAK1 JAK1 TGFB2 TGFB2 RALBP1 RALBP1 MAPK10 MAPK10 MTOR MTOR TGFB1 TGFB1 MAPK9 MAPK9 ARAF ARAF RAF1 RAF1 SMAD2 SMAD2 NFKB1 NFKB1 CASP9 CASP9 TGFA TGFA MAP2K1 MAP2K1 IKBKG IKBKG EGF EGF PIK3CA PIK3CA RELA RELA SMAD4 SMAD4 CDK4 CDK4 RB1 RB1 BRAF BRAF GADD45B GADD45B TGFBR2 TGFBR2 CHUK CHUK DDB2 DDB2 GADD45G GADD45G CCND1 CCND1 MAPK1 MAPK1 TGFB3 TGFB3 KRAS KRAS RALB RALB POLK POLK RGL4 RGL4 IKBKB IKBKB TP53 TP53 RALA RALA RAD51 RAD51 ERBB2 ERBB2 E2F2 E2F2 RALGDS RALGDS AKT2 AKT2 TGFBR1 TGFBR1 AKT3 AKT3 PIK3CD PIK3CD BAX BAX STAT1 STAT1 BAK1 BAK1 EGFR EGFR CDC42 CDC42 GADD45A GADD45A RAC2 RAC2 E2F3 E2F3 PLD1 PLD1 BAD BAD CDK6 CDK6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BRCA2Uncharacterized protein. (386 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RALBP1RalA binding protein 1. (655 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
RAF1Uncharacterized protein. (668 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (372 aa)
TGFATransforming growth factor alpha. (166 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
RELAUncharacterized protein. (282 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RB1RB transcriptional corepressor 1. (815 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (753 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
CCND1Cyclin D1. (156 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RALBRAS like proto-oncogene B. (212 aa)
POLKDNA polymerase kappa. (866 aa)
RGL4Ral guanine nucleotide dissociation stimulator like 4. (471 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
RALARAS like proto-oncogene A. (206 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (337 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
E2F2E2F transcription factor 2. (437 aa)
RALGDSUncharacterized protein. (918 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
CDC42Uncharacterized protein. (191 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
RAC2Rac family small GTPase 2. (192 aa)
E2F3E2F transcription factor 3. (465 aa)
PLD1Phospholipase. (968 aa)
BADBCL2 associated agonist of cell death. (167 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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