STRINGSTRING
MAPK3 MAPK3 PRKCG PRKCG PIK3R1 PIK3R1 PIK3R3 PIK3R3 FHIT FHIT ARAF ARAF RAF1 RAF1 EML4 EML4 RARB RARB CASP9 CASP9 PLCG2 PLCG2 TGFA TGFA MAP2K1 MAP2K1 EGF EGF STAT5B STAT5B GRB2 GRB2 PIK3CA PIK3CA CDK4 CDK4 RB1 RB1 RASSF5 RASSF5 PRKCA PRKCA BRAF BRAF HRAS HRAS GADD45B GADD45B ALK ALK DDB2 DDB2 GADD45G GADD45G CCND1 CCND1 MAPK1 MAPK1 KRAS KRAS POLK POLK JAK3 JAK3 TP53 TP53 STK4 STK4 RXRG RXRG RXRB RXRB ERBB2 ERBB2 E2F2 E2F2 SOS1 SOS1 MET MET AKT2 AKT2 AKT3 AKT3 FOXO3 FOXO3 PIK3CD PIK3CD BAX BAX SOS2 SOS2 BAK1 BAK1 EGFR EGFR PLCG1 PLCG1 RXRA RXRA GADD45A GADD45A NRAS NRAS HGF HGF E2F3 E2F3 BAD BAD CDK6 CDK6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
PRKCGProtein kinase C. (726 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
RAF1Uncharacterized protein. (668 aa)
EML4EMAP like 4. (995 aa)
RARBRetinoic acid receptor beta. (448 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (372 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
TGFATransforming growth factor alpha. (166 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
STAT5BSignal transducer and activator of transcription. (768 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RB1RB transcriptional corepressor 1. (815 aa)
RASSF5Ras association domain family member 5. (418 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (604 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (753 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
ALKTyrosine-protein kinase receptor. (1316 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
CCND1Cyclin D1. (156 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
POLKDNA polymerase kappa. (866 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
STK4Serine/threonine kinase 4. (487 aa)
RXRGRetinoid X receptor gamma. (463 aa)
RXRBRetinoid X receptor beta. (508 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
E2F2E2F transcription factor 2. (437 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1293 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1383 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
FOXO3Forkhead box O3. (672 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1268 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
RXRARetinoid X receptor alpha. (492 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
E2F3E2F transcription factor 3. (465 aa)
BADBCL2 associated agonist of cell death. (167 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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