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TCF7L2 TCF7L2 CACNG1 CACNG1 LOC108517114 LOC108517114 CTNNA2 CTNNA2 ACTB ACTB SLC8A1 SLC8A1 SGCA SGCA ACTN3 ACTN3 CACNG6 CACNG6 CACNA1S CACNA1S SLC8A3 SLC8A3 CACNA2D2 CACNA2D2 CACNG7 CACNG7 LAMA2 LAMA2 RYR2 RYR2 CACNB3 CACNB3 ITGB3 ITGB3 LEF1 LEF1 TCF7 TCF7 TCF7L1 TCF7L1 DAG1 DAG1 SLC8A2 SLC8A2 CACNG5 CACNG5 ITGA3 ITGA3 CACNG3 CACNG3 CACNB4 CACNB4 ITGA11 ITGA11 LAMA1 LAMA1 ITGAV ITGAV ITGA5 ITGA5 CACNB2 CACNB2 ITGB7 ITGB7 CACNA1D CACNA1D ITGB1 ITGB1 CACNA2D3 CACNA2D3 ITGA10 ITGA10 DES DES CTNNB1 CTNNB1 ITGA2B ITGA2B ITGA9 ITGA9 ATP2A2 ATP2A2 ITGA1 ITGA1 ITGA8 ITGA8 EMD EMD CACNA2D1 CACNA2D1 ACTN2 ACTN2 CACNG2 CACNG2 ITGB5 ITGB5 DSP DSP ITGA4 ITGA4 ITGB8 ITGB8 ITGB4 ITGB4 CACNA1F CACNA1F ITGA6 ITGA6 ITGB6 ITGB6 ITGA2 ITGA2 DSG2 DSG2 SGCB SGCB LMNA LMNA CACNG8 CACNG8 CDH2 CDH2 CACNG4 CACNG4 ATP2A1 ATP2A1 SGCD SGCD CTNNA1 CTNNA1 CTNNA3 CTNNA3 DSC2 DSC2 ITGA7 ITGA7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TCF7L2HMG box domain-containing protein. (376 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa)
LOC108517114Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
CTNNA2Catenin alpha 2. (952 aa)
ACTBActin beta. (379 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
SGCASarcoglycan alpha. (441 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (937 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (261 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1140 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
LAMA2Laminin subunit alpha 2. (3094 aa)
RYR2Ryanodine receptor 2. (4866 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (485 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
LEF1Lymphoid enhancer binding factor 1. (398 aa)
TCF7Transcription factor 7. (399 aa)
TCF7L1Transcription factor 7 like 1. (440 aa)
DAG1Dystroglycan 1. (893 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (907 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (274 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1087 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1233 aa)
LAMA1Laminin subunit alpha 1. (3080 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1051 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2180 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (937 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1048 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1168 aa)
DESDesmin; Belongs to the intermediate filament family. (470 aa)
CTNNB1Catenin beta 1. (781 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1105 aa)
ITGA9Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (548 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1037 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
EMDLEM domain-containing protein. (258 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
ACTN2Actinin alpha 2. (857 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (287 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
DSPDesmoplakin. (2857 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (745 aa)
ITGB4Integrin beta. (1823 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1818 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (771 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
DSG2Desmoglein 2. (1118 aa)
SGCBSarcoglycan beta. (313 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (728 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (321 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (886 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (300 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1027 aa)
SGCDUncharacterized protein. (102 aa)
CTNNA1Catenin alpha 1. (906 aa)
CTNNA3Catenin alpha 3. (767 aa)
DSC2Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (901 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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