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LOC108516321 LOC108516321 CALML3 CALML3 CAV3 CAV3 PIK3R1 PIK3R1 SRC SRC PIK3R3 PIK3R3 KDR KDR ACTB ACTB MAPK10 MAPK10 ENSRBIP00000003512 ENSRBIP00000003512 LOC108523776 LOC108523776 MMP9 MMP9 CALML4 CALML4 MAP3K7 MAP3K7 ENSRBIP00000005595 ENSRBIP00000005595 HSP90AB1-2 HSP90AB1-2 MAPK9 MAPK9 ACVR1 ACVR1 GSTA1 GSTA1 LOC108524063 LOC108524063 NCF2 NCF2 ITGB3 ITGB3 CALM1 CALM1 IL1R1 IL1R1 BCL2 BCL2 TNF TNF MEF2A MEF2A CYBA CYBA MGST2 MGST2 NFKB1 NFKB1 BMPR2 BMPR2 BMPR1A BMPR1A IKBKG IKBKG CAV1 CAV1 HMOX1 HMOX1 PDGFB PDGFB ITGAV ITGAV IL1B IL1B PIK3CA PIK3CA RELA RELA HSP90B1 HSP90B1 GSTM3 GSTM3 KEAP1 KEAP1 VCAM1 VCAM1 NPPC NPPC SUMO3 SUMO3 SUMO2 SUMO2 CTSL CTSL LOC108537061 LOC108537061 MMP2 MMP2 MAP2K6 MAP2K6 SDC1 SDC1 GSTA3 GSTA3 GSTO1 GSTO1 NQO1 NQO1 CTNNB1 CTNNB1 LOC108524065 LOC108524065 TXN2 TXN2 ARHGEF2 ARHGEF2 ITGA2B ITGA2B CHUK CHUK FOS FOS PRKAA1 PRKAA1 DUSP1 DUSP1 ASS1 ASS1 CAV2 CAV2 EDN1 EDN1 PLAT PLAT PDGFA PDGFA IKBKB IKBKB MAPK14 MAPK14 KLF2 KLF2 TP53 TP53 ACVR2B ACVR2B PECAM1 PECAM1 LOC108543421 LOC108543421 MAP3K5 MAP3K5 MAP2K4 MAP2K4 ENSRBIP00000030956 ENSRBIP00000030956 NOX1 NOX1 IFNG IFNG LOC108513861 LOC108513861 ICAM1 ICAM1 CCL2 CCL2 SELE SELE MAPK13 MAPK13 GSTO2 GSTO2 CALM3 CALM3 SQSTM1 SQSTM1 AKT2 AKT2 NOS3 NOS3 AKT3 AKT3 GSTA4 GSTA4 CDH5 CDH5 MAPK11 MAPK11 PIK3CD PIK3CD GSTP1 GSTP1 BMPR1B BMPR1B IL1A IL1A TRPV4 TRPV4 MAP2K7 MAP2K7 IL1R2 IL1R2 PIAS4 PIAS4 PRKAA2 PRKAA2 ACVR2A ACVR2A MAP2K5 MAP2K5 MAPK7 MAPK7 NFE2L2 NFE2L2 BMP4 BMP4 TNFRSF1A TNFRSF1A RAC2 RAC2 MGST3 MGST3 SDC4 SDC4 TXN TXN RHOA RHOA SDC2 SDC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108516321Uncharacterized protein; Belongs to the GST superfamily. (241 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SRCTyrosine-protein kinase. (627 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ACTBActin beta. (379 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
ENSRBIP00000003512Small ubiquitin-related modifier. (95 aa)
LOC108523776Uncharacterized protein. (150 aa)
MMP9Matrix metallopeptidase 9. (703 aa)
CALML4Calmodulin like 4. (192 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ENSRBIP00000005595Uncharacterized protein. (140 aa)
HSP90AB1-2HATPase_c domain-containing protein. (724 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
GSTA1Glutathione S-transferase. (222 aa)
LOC108524063Uncharacterized protein; Belongs to the GST superfamily. (244 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
IL1R1Interleukin 1 receptor type 1. (568 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MEF2AMyocyte enhancer factor 2A. (511 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
HMOX1Heme oxygenase 1. (284 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (237 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
RELAUncharacterized protein. (282 aa)
HSP90B1Heat shock protein 90 beta family member 1. (799 aa)
GSTM3Glutathione S-transferase. (225 aa)
KEAP1Kelch like ECH associated protein 1. (368 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
NPPCNatriuretic peptide C. (126 aa)
SUMO3Small ubiquitin-related modifier. (97 aa)
SUMO2Ubiquitin-like domain-containing protein. (80 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (341 aa)
LOC108537061HATPase_c domain-containing protein. (384 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (338 aa)
GSTA3Glutathione S-transferase alpha 3. (222 aa)
GSTO1Uncharacterized protein. (241 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
CTNNB1Catenin beta 1. (781 aa)
LOC108524065Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
TXN2Thioredoxin 2. (166 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1003 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1105 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
ASS1Uncharacterized protein. (412 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
EDN1Endothelin 1. (211 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (303 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
KLF2Uncharacterized protein. (194 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (756 aa)
LOC108543421Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (408 aa)
ENSRBIP00000030956Small ubiquitin-related modifier. (123 aa)
NOX1NADPH oxidase 1. (532 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (159 aa)
LOC108513861Thioredoxin domain-containing protein. (104 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
CCL2C-C motif chemokine. (99 aa)
SELESelectin E. (610 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (163 aa)
SQSTM1Sequestosome 1. (451 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
GSTA4Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (222 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (788 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (414 aa)
IL1R2Interleukin 1 receptor type 2. (397 aa)
PIAS4Protein inhibitor of activated STAT 4. (508 aa)
PRKAA2Non-specific serine/threonine protein kinase. (539 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (605 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
RAC2Rac family small GTPase 2. (192 aa)
MGST3Microsomal glutathione S-transferase 3. (166 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
RHOAUncharacterized protein. (104 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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