STRINGSTRING
DDX56 DDX56 CD19 CD19 ENSRROP00000045686 ENSRROP00000045686 SMARCA4 SMARCA4 ENSRROP00000045588 ENSRROP00000045588 EIF4EBP1 EIF4EBP1 FBXW7 FBXW7 CTBP1 CTBP1 DDX17 DDX17 WRN WRN ENSRROP00000000058 ENSRROP00000000058 CREBBP CREBBP HNRNPF HNRNPF ENSRROP00000000616 ENSRROP00000000616 MSH2 MSH2 ENSRROP00000000684 ENSRROP00000000684 CNOT1 CNOT1 ENSRROP00000001202 ENSRROP00000001202 LOC104655302 LOC104655302 MDC1 MDC1 TP53BP1 TP53BP1 SUFU SUFU CHD7 CHD7 ANK3 ANK3 ATP2B4 ATP2B4 ENSRROP00000002607 ENSRROP00000002607 ZBTB33 ZBTB33 SLC38A9 SLC38A9 CDC73 CDC73 PXN PXN MAP2K7 MAP2K7 GJC1 GJC1 PDPK1 PDPK1 FANCI FANCI ANKS6 ANKS6 SMC3 SMC3 TET2 TET2 ARHGEF12 ARHGEF12 PNMA2 PNMA2 SMARCA2 SMARCA2 TRPC4 TRPC4 WT1 WT1 LOC104678914 LOC104678914 HMGA1 HMGA1 POLDIP3 POLDIP3 TRIM32 TRIM32 ADRB2 ADRB2 MAPKAP1 MAPKAP1 TMEM192 TMEM192 LOC104656641 LOC104656641 LOC104674456 LOC104674456 USP28 USP28 PGRMC1 PGRMC1 HSPA8-2 HSPA8-2 ATRX ATRX DCP2 DCP2 SLC8A1 SLC8A1 USP1 USP1 ELN ELN ENSRROP00000008784 ENSRROP00000008784 WTAP WTAP FANCA FANCA EHMT2 EHMT2 NOX4 NOX4 CDC5L CDC5L CTSC CTSC DNAJC7 DNAJC7 PARP1 PARP1 SSBP1 SSBP1 SMARCA5 SMARCA5 HUWE1 HUWE1 METTL3 METTL3 XPA XPA AFDN AFDN TOP2B TOP2B ENSRROP00000011286 ENSRROP00000011286 EMD EMD RGS12 RGS12 RAD52 RAD52 G3BP1 G3BP1 UBR1 UBR1 LOC104654620 LOC104654620 ENSRROP00000012537 ENSRROP00000012537 SRRT SRRT SMARCB1 SMARCB1 CLSPN CLSPN LOC104662872 LOC104662872 UIMC1 UIMC1 PPP6C PPP6C NECTIN3 NECTIN3 KHSRP KHSRP TOPBP1 TOPBP1 ILF2 ILF2 RBBP6 RBBP6 RIC8A RIC8A SLC12A4 SLC12A4 DDX6 DDX6 CCP110 CCP110 TERT TERT ENSRROP00000017094 ENSRROP00000017094 FANCD2 FANCD2 RANBP3 RANBP3 NCSTN NCSTN HSPA8 HSPA8 MAP1A MAP1A ENSRROP00000018578 ENSRROP00000018578 OXSR1 OXSR1 VCP VCP NPHP3 NPHP3 FKBP4 FKBP4 APPL1 APPL1 CNOT4 CNOT4 ENSRROP00000019367 ENSRROP00000019367 CASP8AP2 CASP8AP2 LOC104682193 LOC104682193 PTGES3 PTGES3 ADAR ADAR YAP1 YAP1 MANEA MANEA LARP1 LARP1 ENSRROP00000020473 ENSRROP00000020473 ENSRROP00000020528 ENSRROP00000020528 PPIG PPIG EDC4 EDC4 PSME3 PSME3 ENSRROP00000021007 ENSRROP00000021007 TUT7 TUT7 AKT3 AKT3 PSMD14 PSMD14 INPP5E INPP5E EXO1 EXO1 MECOM MECOM LOC104666830 LOC104666830 PTPN14 PTPN14 ENSRROP00000022699 ENSRROP00000022699 USP9Y USP9Y CREB1 CREB1 SLC9A1 SLC9A1 ENSRROP00000023205 ENSRROP00000023205 PYCR1 PYCR1 BID BID MAP1B MAP1B ARHGAP35 ARHGAP35 LATS1 LATS1 ENSRROP00000024190 ENSRROP00000024190 LOC104679892 LOC104679892 PKHD1 PKHD1 RANBP9 RANBP9 PACS1 PACS1 MEN1 MEN1 MAPK14 MAPK14 ARID1A ARID1A U2AF1 U2AF1 SLIT2 SLIT2 ENSRROP00000026122 ENSRROP00000026122 NEIL2 NEIL2 CDKN1B CDKN1B TP53 TP53 DKK1 DKK1 CLTC CLTC ENSRROP00000027506 ENSRROP00000027506 LSM14A LSM14A STUB1 STUB1 DNAJB11 DNAJB11 LOC104667986 LOC104667986 SMC1A SMC1A BCL2L11 BCL2L11 ENSRROP00000028809 ENSRROP00000028809 DCTN2 DCTN2 ENSRROP00000029075 ENSRROP00000029075 ENSRROP00000029157 ENSRROP00000029157 FREM2 FREM2 CEP170 CEP170 AKAP12 AKAP12 MED1 MED1 HSPA4 HSPA4 USF1 USF1 TCF12 TCF12 SESN1 SESN1 BRCA2 BRCA2 TRPC3 TRPC3 NPHS1 NPHS1 SHPK SHPK ATM ATM CRBN CRBN HSPB1 HSPB1 AASDHPPT AASDHPPT AMOT AMOT UBE3A UBE3A KIF11 KIF11 LOC104658975 LOC104658975 VPS4B VPS4B BRCA1 BRCA1 TSC1 TSC1 ENSRROP00000034135 ENSRROP00000034135 SH2D3A SH2D3A LOC104666999 LOC104666999 TRIM28 TRIM28 SEC13 SEC13 ENSRROP00000034731 ENSRROP00000034731 UPF1 UPF1 USP9X USP9X ATAD5 ATAD5 CEP97 CEP97 MOV10 MOV10 UCHL3 UCHL3 KDM3A KDM3A NCOA1 NCOA1 OCLN OCLN EPS15 EPS15 RAF1 RAF1 PPP1R12C PPP1R12C NOX3 NOX3 SMG1 SMG1 CHD4 CHD4 ENSRROP00000038395 ENSRROP00000038395 ENSRROP00000038482 ENSRROP00000038482 ELL ELL LOC104672183 LOC104672183 TUBA1B TUBA1B PSMA7 PSMA7 NIN NIN NONO NONO RPA1 RPA1 ENSRROP00000040427 ENSRROP00000040427 PEG3 PEG3 ZDHHC20 ZDHHC20 ROCK1 ROCK1 PSIP1 PSIP1 NPHP1 NPHP1 PSMD2 PSMD2 CFLAR CFLAR LOC104677400 LOC104677400 DHX9 DHX9 HSP90AB1 HSP90AB1 CUX1 CUX1 CTNND1 CTNND1 ENSRROP00000044073 ENSRROP00000044073 NUBP2 NUBP2 PRKDC PRKDC FKBP5 FKBP5 TPI1 TPI1 PPP1CC PPP1CC CD46 CD46 EHMT1 EHMT1 HERC5 HERC5 ATP6V0A2 ATP6V0A2 KAT6A KAT6A XRN1 XRN1 PSMD4 PSMD4 GABARAPL2 GABARAPL2 RBM14 RBM14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDX56DEAD-box helicase 56. (547 aa)
CD19CD19 molecule. (558 aa)
ENSRROP00000045686Uncharacterized protein. (153 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
ENSRROP00000045588Ubiquitin-like domain-containing protein. (137 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (448 aa)
DDX17DEAD-box helicase 17; Belongs to the DEAD box helicase family. (735 aa)
WRNWRN RecQ like helicase. (1431 aa)
ENSRROP00000000058Uncharacterized protein. (224 aa)
CREBBPCREB binding protein. (2442 aa)
HNRNPFHeterogeneous nuclear ribonucleoprotein F. (415 aa)
ENSRROP00000000616CS domain-containing protein. (136 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
ENSRROP00000000684Triosephosphate isomerase. (139 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2376 aa)
ENSRROP00000001202RRM domain-containing protein. (172 aa)
LOC104655302SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
MDC1Mediator of DNA damage checkpoint 1. (2029 aa)
TP53BP1Tumor protein p53 binding protein 1. (1976 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (514 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
ANK3Ankyrin 3. (4381 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
ENSRROP00000002607Uncharacterized protein. (99 aa)
ZBTB33Zinc finger and BTB domain containing 33. (672 aa)
SLC38A9Solute carrier family 38 member 9. (561 aa)
CDC73Cell division cycle 73. (531 aa)
PXNPaxillin. (1082 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (403 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (356 aa)
FANCIFA complementation group I. (1328 aa)
ANKS6Ankyrin repeat and sterile alpha motif domain containing 6. (778 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
TET2Tet methylcytosine dioxygenase 2. (2022 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
PNMA2PNMA family member 2. (364 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1570 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
WT1WT1 transcription factor. (500 aa)
LOC104678914NADPH oxidase 4. (353 aa)
HMGA1Uncharacterized protein. (105 aa)
POLDIP3DNA polymerase delta interacting protein 3. (421 aa)
TRIM32Tripartite motif containing 32. (653 aa)
ADRB2Adrenoceptor beta 2. (415 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
TMEM192Transmembrane protein 192. (236 aa)
LOC104656641Uncharacterized protein. (1088 aa)
LOC104674456Ubiquitin-like domain-containing protein. (118 aa)
USP28Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1139 aa)
PGRMC1Progesterone receptor membrane component 1; Belongs to the cytochrome b5 family. (195 aa)
HSPA8-2Uncharacterized protein. (129 aa)
ATRXUncharacterized protein. (164 aa)
DCP2Decapping mRNA 2. (420 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa)
ELNElastin. (723 aa)
ENSRROP00000008784C3H1-type domain-containing protein. (247 aa)
WTAPWT1 associated protein. (319 aa)
FANCAFA complementation group A. (1455 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1237 aa)
NOX4NAD_binding_6 domain-containing protein. (254 aa)
CDC5LCell division cycle 5 like. (802 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (463 aa)
DNAJC7DnaJ heat shock protein family (Hsp40) member C7. (494 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1044 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4423 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
AFDNAfadin, adherens junction formation factor. (1814 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1622 aa)
ENSRROP00000011286RRM domain-containing protein. (274 aa)
EMDLEM domain-containing protein. (251 aa)
RGS12Regulator of G protein signaling 12. (1447 aa)
RAD52RAD52 homolog, DNA repair protein. (419 aa)
G3BP1G3BP stress granule assembly factor 1. (466 aa)
UBR1E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1749 aa)
LOC104654620Uncharacterized protein; Belongs to the heat shock protein 70 family. (627 aa)
ENSRROP00000012537LEDGF domain-containing protein. (203 aa)
SRRTSerrate, RNA effector molecule. (876 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (418 aa)
CLSPNClaspin. (1340 aa)
LOC104662872Uncharacterized protein. (115 aa)
UIMC1Ubiquitin interaction motif containing 1. (719 aa)
PPP6CSerine/threonine-protein phosphatase. (305 aa)
NECTIN3Nectin cell adhesion molecule 3. (538 aa)
KHSRPKH-type splicing regulatory protein. (711 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1527 aa)
ILF2Interleukin enhancer binding factor 2. (360 aa)
RBBP6RB binding protein 6, ubiquitin ligase. (1792 aa)
RIC8ARIC8 guanine nucleotide exchange factor A. (529 aa)
SLC12A4Solute carrier family 12 member 4. (1085 aa)
DDX6DEAD-box helicase 6; Belongs to the DEAD box helicase family. (483 aa)
CCP110Centriolar coiled-coil protein 110. (1037 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
ENSRROP00000017094Uncharacterized protein. (403 aa)
FANCD2Uncharacterized protein. (1425 aa)
RANBP3RAN binding protein 3. (576 aa)
NCSTNNicastrin. (709 aa)
HSPA8Uncharacterized protein; Belongs to the heat shock protein 70 family. (605 aa)
MAP1AMicrotubule associated protein 1A. (3040 aa)
ENSRROP00000018578Uncharacterized protein; Belongs to the heat shock protein 70 family. (586 aa)
OXSR1Oxidative stress responsive kinase 1. (527 aa)
VCPValosin containing protein. (754 aa)
NPHP3TPR_REGION domain-containing protein. (1328 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (693 aa)
CNOT4C3H1-type domain-containing protein. (246 aa)
ENSRROP00000019367Triosephosphate isomerase. (217 aa)
CASP8AP2Caspase 8 associated protein 2. (1983 aa)
LOC104682193Uncharacterized protein. (459 aa)
PTGES3CS domain-containing protein. (164 aa)
ADARAdenosine deaminase RNA specific. (1241 aa)
YAP1Yes associated protein 1. (508 aa)
MANEAMannosidase endo-alpha. (462 aa)
LARP1La ribonucleoprotein domain family member 1. (1021 aa)
ENSRROP00000020473FFD domain-containing protein. (348 aa)
ENSRROP00000020528Uncharacterized protein. (630 aa)
PPIGPeptidylprolyl isomerase G. (754 aa)
EDC4Enhancer of mRNA decapping 4. (1414 aa)
PSME3Proteasome activator subunit 3. (267 aa)
ENSRROP00000021007Uncharacterized protein. (427 aa)
TUT7Terminal uridylyl transferase 7. (1490 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (315 aa)
INPP5EInositol polyphosphate-5-phosphatase E. (645 aa)
EXO1Exonuclease 1. (846 aa)
MECOMMDS1 and EVI1 complex locus. (1217 aa)
LOC104666830Uncharacterized protein. (286 aa)
PTPN14Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1187 aa)
ENSRROP00000022699Uncharacterized protein. (356 aa)
USP9YUbiquitin specific peptidase 9 Y-linked; Belongs to the peptidase C19 family. (2551 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
ENSRROP00000023205LEM domain-containing protein. (219 aa)
PYCR1Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (346 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (226 aa)
MAP1BMicrotubule associated protein 1B. (2468 aa)
ARHGAP35Rho GTPase activating protein 35. (1499 aa)
LATS1Large tumor suppressor kinase 1. (1130 aa)
ENSRROP00000024190Protein kinase domain-containing protein. (137 aa)
LOC104679892BRCT domain-containing protein. (96 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4093 aa)
RANBP9RAN binding protein 9. (657 aa)
PACS1Phosphofurin acidic cluster sorting protein 1. (1027 aa)
MEN1Menin 1. (610 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ARID1AAT-rich interaction domain 1A. (2289 aa)
U2AF1Uncharacterized protein. (248 aa)
SLIT2Slit guidance ligand 2. (1224 aa)
ENSRROP00000026122Uncharacterized protein. (207 aa)
NEIL2Nei like DNA glycosylase 2. (332 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
ENSRROP00000027506Uncharacterized protein. (54 aa)
LSM14AUncharacterized protein. (468 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
DNAJB11J domain-containing protein. (358 aa)
LOC104667986Uncharacterized protein. (96 aa)
SMC1AStructural maintenance of chromosomes protein. (1251 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
ENSRROP0000002880926S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (818 aa)
DCTN2Dynactin subunit 2. (427 aa)
ENSRROP00000029075Uncharacterized protein. (168 aa)
ENSRROP00000029157Uncharacterized protein. (457 aa)
FREM2FRAS1 related extracellular matrix 2. (3170 aa)
CEP170Centrosomal protein 170. (1629 aa)
AKAP12A-kinase anchoring protein 12. (1783 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
HSPA4Heat shock protein family A (Hsp70) member 4. (840 aa)
USF1Upstream transcription factor 1. (310 aa)
TCF12Transcription factor 12. (706 aa)
SESN1Sestrin 1. (551 aa)
BRCA2BRCA2 DNA repair associated. (3418 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa)
NPHS1Uncharacterized protein. (1150 aa)
SHPKFGGY_N domain-containing protein. (479 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
CRBNCereblon. (488 aa)
HSPB1SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
AASDHPPTAminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase. (309 aa)
AMOTAngiomotin. (1086 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
KIF11Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1056 aa)
LOC104658975Uncharacterized protein. (375 aa)
VPS4BVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (444 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1836 aa)
TSC1TSC complex subunit 1. (1163 aa)
ENSRROP00000034135Poly [ADP-ribose] polymerase. (856 aa)
SH2D3ASH2 domain containing 3A. (582 aa)
LOC104666999Uncharacterized protein. (1010 aa)
TRIM28Tripartite motif containing 28. (806 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (331 aa)
ENSRROP00000034731Uncharacterized protein. (284 aa)
UPF1UPF1 RNA helicase and ATPase. (1079 aa)
USP9XUncharacterized protein. (278 aa)
ATAD5ATPase family AAA domain containing 5. (1834 aa)
CEP97Centrosomal protein 97. (865 aa)
MOV10Mov10 RISC complex RNA helicase. (1003 aa)
UCHL3Ubiquitin carboxyl-terminal hydrolase. (230 aa)
KDM3ALysine demethylase 3A. (1322 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (899 aa)
RAF1Uncharacterized protein. (668 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (821 aa)
NOX3NADPH oxidase 3. (570 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (2596 aa)
CHD4Uncharacterized protein. (1913 aa)
ENSRROP00000038395Uncharacterized protein. (401 aa)
ENSRROP00000038482Uncharacterized protein. (282 aa)
ELLElongation factor for RNA polymerase II. (621 aa)
LOC104672183HATPase_c domain-containing protein. (724 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (453 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
NINNinein. (2134 aa)
NONONon-POU domain containing octamer binding. (471 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (580 aa)
ENSRROP00000040427Uncharacterized protein. (60 aa)
PEG3Paternally expressed 3. (1466 aa)
ZDHHC20Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (325 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
PSIP1PWWP domain-containing protein. (530 aa)
NPHP1Nephrocystin 1. (735 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (508 aa)
LOC104677400Uncharacterized protein. (173 aa)
DHX9DExH-box helicase 9. (1275 aa)
HSP90AB1HATPase_c domain-containing protein. (724 aa)
CUX1Homeobox protein cut-like. (1566 aa)
CTNND1Catenin delta 1. (971 aa)
ENSRROP00000044073Uncharacterized protein. (366 aa)
NUBP2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (271 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4159 aa)
FKBP5Peptidylprolyl isomerase. (457 aa)
TPI1Triosephosphate isomerase. (286 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CD46CD46 molecule. (399 aa)
EHMT1Euchromatic histone lysine methyltransferase 1. (1281 aa)
HERC5HECT and RLD domain containing E3 ubiquitin protein ligase 5. (1022 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2003 aa)
XRN15'-3' exoribonuclease 1. (926 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (378 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
RBM14RNA binding motif protein 14. (669 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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