(46 nodes) Fatty acid beta-oxidation, and Ketone body metabolism network (Rhinopithecus roxellana)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ACADL	Acyl-CoA dehydrogenase long chain. (430 aa)
	BDH2	3-hydroxybutyrate dehydrogenase 2. (245 aa)
	ACOX1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
	HADHB	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa)
	HSD17B4	Hydroxysteroid 17-beta dehydrogenase 4. (759 aa)
	ACADS	Acyl-CoA dehydrogenase short chain. (412 aa)
	ECHDC1	Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (307 aa)
	CPT2	Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (659 aa)
	ACAA1	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
	STOML1	Stomatin like 1. (402 aa)
	AACS	Acetoacetyl-CoA synthetase. (672 aa)
	ACAT2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	ACSS3	Acyl-CoA synthetase short chain family member 3. (686 aa)
	AMACR	Alpha-methylacyl-CoA racemase. (382 aa)
	ACOXL	Acyl-CoA_dh_M domain-containing protein. (249 aa)
	ENSRROP00000016332	Uncharacterized protein. (722 aa)
	HSD17B10	Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
	ACADM	Acyl-CoA dehydrogenase medium chain. (454 aa)
	HADHA	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (765 aa)
	ECI2	Enoyl-CoA delta isomerase 2. (391 aa)
	ECI1	Enoyl-CoA delta isomerase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (302 aa)
	ETFDH	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (619 aa)
	ACAA2	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	HMGCS2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
	HADH	Hydroxyacyl-CoA dehydrogenase. (342 aa)
	ETFA	Electron transfer flavoprotein subunit alpha. (333 aa)
	CRYL1	Crystallin lambda 1. (319 aa)
	ACAD8	Acyl-CoA dehydrogenase family member 8. (441 aa)
	HMGCLL1	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (304 aa)
	ACADVL	Acyl-CoA dehydrogenase very long chain. (655 aa)
	AUH	AU RNA binding methylglutaconyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (341 aa)
	OXCT1	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (557 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
	HMGCL	3-hydroxy-3-methylglutaryl-CoA lyase. (325 aa)
	ECHDC2	Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family. (292 aa)
	ACOX3	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa)
	EHHADH	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (723 aa)
	CARTPT	CART prepropeptide. (116 aa)
	ETFB	Electron transfer flavoprotein subunit beta. (345 aa)
	PECR	Peroxisomal trans-2-enoyl-CoA reductase. (322 aa)
	ACOX2	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa)
	ECHS1	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family. (290 aa)
	ACADSB	Acyl-CoA dehydrogenase short/branched chain. (401 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
	ENSRROP00000045789	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (357 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AACS	ACAA1	ENSRROP00000012975	ENSRROP00000010960	Acetoacetyl-CoA synthetase.	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.528
AACS	ACAA2	ENSRROP00000012975	ENSRROP00000020562	Acetoacetyl-CoA synthetase.	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.521
AACS	ACAD8	ENSRROP00000012975	ENSRROP00000027349	Acetoacetyl-CoA synthetase.	Acyl-CoA dehydrogenase family member 8.	0.412
AACS	ACADL	ENSRROP00000012975	ENSRROP00000001889	Acetoacetyl-CoA synthetase.	Acyl-CoA dehydrogenase long chain.	0.463
AACS	ACADM	ENSRROP00000012975	ENSRROP00000017061	Acetoacetyl-CoA synthetase.	Acyl-CoA dehydrogenase medium chain.	0.420
AACS	ACADS	ENSRROP00000012975	ENSRROP00000008164	Acetoacetyl-CoA synthetase.	Acyl-CoA dehydrogenase short chain.	0.412
AACS	ACADSB	ENSRROP00000012975	ENSRROP00000039304	Acetoacetyl-CoA synthetase.	Acyl-CoA dehydrogenase short/branched chain.	0.412
AACS	ACADVL	ENSRROP00000012975	ENSRROP00000028578	Acetoacetyl-CoA synthetase.	Acyl-CoA dehydrogenase very long chain.	0.412
AACS	ACAT1	ENSRROP00000012975	ENSRROP00000022356	Acetoacetyl-CoA synthetase.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.962
AACS	ACAT2	ENSRROP00000012975	ENSRROP00000013002	Acetoacetyl-CoA synthetase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.950
AACS	ACOX1	ENSRROP00000012975	ENSRROP00000005915	Acetoacetyl-CoA synthetase.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.471
AACS	ACOX2	ENSRROP00000012975	ENSRROP00000037573	Acetoacetyl-CoA synthetase.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.471
AACS	ACOX3	ENSRROP00000012975	ENSRROP00000035414	Acetoacetyl-CoA synthetase.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.450
AACS	ACOXL	ENSRROP00000012975	ENSRROP00000015315	Acetoacetyl-CoA synthetase.	Acyl-CoA_dh_M domain-containing protein.	0.450
AACS	AUH	ENSRROP00000012975	ENSRROP00000031798	Acetoacetyl-CoA synthetase.	AU RNA binding methylglutaconyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.436
AACS	BDH2	ENSRROP00000012975	ENSRROP00000004468	Acetoacetyl-CoA synthetase.	3-hydroxybutyrate dehydrogenase 2.	0.929
AACS	CARTPT	ENSRROP00000012975	ENSRROP00000035449	Acetoacetyl-CoA synthetase.	CART prepropeptide.	0.524
AACS	CRYL1	ENSRROP00000012975	ENSRROP00000025290	Acetoacetyl-CoA synthetase.	Crystallin lambda 1.	0.552
AACS	ECHDC1	ENSRROP00000012975	ENSRROP00000008484	Acetoacetyl-CoA synthetase.	Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family.	0.471
AACS	ECHDC2	ENSRROP00000012975	ENSRROP00000034875	Acetoacetyl-CoA synthetase.	Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family.	0.436