STRINGSTRING
ASXL1 ASXL1 CREBBP CREBBP SIRT6 SIRT6 PASD1 PASD1 HIF1A HIF1A VHL VHL ENSRROP00000000669 ENSRROP00000000669 HCFC1 HCFC1 NMRK1 NMRK1 BST1 BST1 C6orf62 C6orf62 THRA THRA PPARGC1A PPARGC1A EGLN1 EGLN1 NFIL3 NFIL3 SRA1 SRA1 ABCA5 ABCA5 NMNAT3 NMNAT3 MBD5 MBD5 NNT NNT LOC104682414 LOC104682414 WT1 WT1 RXRG RXRG LOC104655511 LOC104655511 ENSRROP00000005469 ENSRROP00000005469 NR1D1 NR1D1 BCL6 BCL6 NADSYN1 NADSYN1 ENSRROP00000007230 ENSRROP00000007230 NRIP1 NRIP1 QPRT QPRT NADK2 NADK2 THRB THRB NR1D2 NR1D2 SIRT4 SIRT4 OGT OGT SP1 SP1 PPARGC1B PPARGC1B ARNTL2 ARNTL2 USP47 USP47 NR6A1 NR6A1 EGLN3 EGLN3 TBL1X TBL1X PER2 PER2 NRF1 NRF1 CD38 CD38 CIART CIART HDAC9 HDAC9 NPAS4 NPAS4 CRY2 CRY2 PPARA PPARA SIRT5 SIRT5 DBP DBP FOXK1 FOXK1 ARNT ARNT AHR AHR EGLN2 EGLN2 PER1 PER1 AIPL1 AIPL1 HIF3A HIF3A RARA RARA ENSRROP00000018274 ENSRROP00000018274 CARM1 CARM1 SALL3 SALL3 NR1I3 NR1I3 SIRT1 SIRT1 ASXL2 ASXL2 AHRR AHRR HLX HLX RARG RARG KMT2E KMT2E CRY1 CRY1 NAMPT NAMPT TTC9C TTC9C LOC104660272 LOC104660272 ARNT2 ARNT2 HIF1AN HIF1AN CLOCK CLOCK SIM1 SIM1 FOXO4 FOXO4 ENSRROP00000024570 ENSRROP00000024570 ARNTL ARNTL NR0B1 NR0B1 NPAS2 NPAS2 SIRT3 SIRT3 NNMT NNMT PAX8 PAX8 SOX9 SOX9 BCOR BCOR HLF HLF NR5A2 NR5A2 TP53 TP53 XPR1 XPR1 BHLHE41 BHLHE41 EP300 EP300 ESRRG ESRRG RORB RORB ABCA1 ABCA1 NAPRT NAPRT SREBF1 SREBF1 ENSRROP00000031184 ENSRROP00000031184 ESRRA ESRRA BHLHE40 BHLHE40 NCOR1 NCOR1 ESR2 ESR2 HCFC2 HCFC2 CSNK1E CSNK1E RARB RARB FOXI2 FOXI2 NCOA2 NCOA2 NR1H2 NR1H2 NR1H4 NR1H4 BAP1 BAP1 NPAS3 NPAS3 GPS2 GPS2 FOXO6 FOXO6 NUDT12 NUDT12 EPAS1 EPAS1 RXRB RXRB NCOA1 NCOA1 NMNAT1 NMNAT1 FOXO1 FOXO1 CSNK1D CSNK1D ISOC2 ISOC2 FBXW11 FBXW11 NR0B2 NR0B2 NCOR2 NCOR2 RXRA RXRA MROH6 MROH6 TBL1XR1 TBL1XR1 LOC104655538 LOC104655538 NMNAT2 NMNAT2 SIRT2 SIRT2 LOC104657883 LOC104657883 PER3 PER3 FOXK2 FOXK2 NPAS1 NPAS1 CDH19 CDH19 USP7 USP7 OVGP1 OVGP1 PLAC8 PLAC8 RORA RORA NCOA3 NCOA3 NR5A1 NR5A1 BCL6B BCL6B NMRK2 NMRK2 PPARG PPARG LOC104678360 LOC104678360 AIP AIP ISOC1 ISOC1 NR1H3 NR1H3 TEF TEF SIRT7 SIRT7 ENSRROP00000045774 ENSRROP00000045774
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ASXL1ASXL transcriptional regulator 1. (1536 aa)
CREBBPCREB binding protein. (2442 aa)
SIRT6Sirtuin 6. (355 aa)
PASD1PAS domain containing repressor 1. (687 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
VHLVon Hippel-Lindau tumor suppressor. (213 aa)
ENSRROP00000000669Fork-head domain-containing protein. (435 aa)
HCFC1Host cell factor C1. (2080 aa)
NMRK1Nicotinamide riboside kinase 1. (207 aa)
BST1Bone marrow stromal cell antigen 1. (316 aa)
C6orf62Chromosome 6 open reading frame 62. (229 aa)
THRAThyroid hormone receptor alpha. (590 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
EGLN1Fe2OG dioxygenase domain-containing protein. (128 aa)
NFIL3Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...] (462 aa)
SRA1Steroid receptor RNA activator 1. (235 aa)
ABCA5ATP binding cassette subfamily A member 5. (1543 aa)
NMNAT3Nicotinamide-nucleotide adenylyltransferase. (252 aa)
MBD5Methyl-CpG binding domain protein 5. (1732 aa)
NNTAlaDh_PNT_C domain-containing protein. (799 aa)
LOC104682414WD_REPEATS_REGION domain-containing protein. (489 aa)
WT1WT1 transcription factor. (500 aa)
RXRGRetinoid X receptor gamma. (463 aa)
LOC104655511Uncharacterized protein. (196 aa)
ENSRROP00000005469Uncharacterized protein. (53 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
BCL6BCL6 transcription repressor. (706 aa)
NADSYN1Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (706 aa)
ENSRROP00000007230Uncharacterized protein. (193 aa)
NRIP1Nuclear receptor interacting protein 1. (1155 aa)
QPRTNicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (305 aa)
NADK2NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. (464 aa)
THRBThyroid hormone receptor beta. (476 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (578 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
SP1Sp1 transcription factor. (786 aa)
PPARGC1BPPARG coactivator 1 beta. (1024 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (622 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
NR6A1Nuclear receptor subfamily 6 group A member 1. (480 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
TBL1XTransducin beta like 1 X-linked. (575 aa)
PER2Period circadian regulator 2. (1253 aa)
NRF1Nuclear respiratory factor 1. (522 aa)
CD38CD38 molecule. (301 aa)
CIARTCircadian associated repressor of transcription. (385 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa)
NPAS4Neuronal PAS domain protein 4. (802 aa)
CRY2Cryptochrome circadian regulator 2. (614 aa)
PPARAPeroxisome proliferator activated receptor alpha. (398 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa)
DBPD-box binding PAR bZIP transcription factor. (317 aa)
FOXK1Forkhead box K1. (733 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (844 aa)
AHRUncharacterized protein. (850 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (405 aa)
PER1Period circadian regulator 1. (1292 aa)
AIPL1Aryl hydrocarbon receptor interacting protein like 1. (384 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (669 aa)
RARARetinoic acid receptor alpha. (478 aa)
ENSRROP00000018274CN hydrolase domain-containing protein. (92 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (564 aa)
SALL3Spalt like transcription factor 3. (1163 aa)
NR1I3Nuclear receptor subfamily 1 group I member 3. (353 aa)
SIRT1Sirtuin 1. (746 aa)
ASXL2ASXL transcriptional regulator 2. (1435 aa)
AHRRUncharacterized protein. (705 aa)
HLXH2.0 like homeobox. (494 aa)
RARGRetinoic acid receptor gamma. (456 aa)
KMT2ELysine methyltransferase 2E. (1878 aa)
CRY1Cryptochrome circadian regulator 1. (586 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (499 aa)
TTC9CTetratricopeptide repeat domain 9C. (171 aa)
LOC104660272Fork-head domain-containing protein. (213 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (723 aa)
HIF1ANHypoxia inducible factor 1 subunit alpha inhibitor. (349 aa)
CLOCKClock circadian regulator. (847 aa)
SIM1SIM bHLH transcription factor 1. (766 aa)
FOXO4Forkhead box O4. (505 aa)
ENSRROP00000024570CTP_transf_like domain-containing protein. (151 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (626 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (470 aa)
NPAS2Neuronal PAS domain protein 2. (824 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
NNMTNicotinamide N-methyltransferase. (264 aa)
PAX8Paired box 8. (486 aa)
SOX9SRY-box transcription factor 9. (509 aa)
BCORBCL6 corepressor. (1755 aa)
HLFHLF transcription factor, PAR bZIP family member. (295 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (538 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
XPR1Xenotropic and polytropic retrovirus receptor 1. (696 aa)
BHLHE41Uncharacterized protein. (334 aa)
EP300E1A binding protein p300. (2413 aa)
ESRRGEstrogen related receptor gamma. (470 aa)
RORBRAR related orphan receptor B. (475 aa)
ABCA1ATP binding cassette subfamily A member 1. (2261 aa)
NAPRTNicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (547 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
ENSRROP00000031184Fork-head domain-containing protein. (193 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
BHLHE40Basic helix-loop-helix family member e40. (412 aa)
NCOR1Nuclear receptor corepressor 1. (2440 aa)
ESR2Estrogen receptor 2. (530 aa)
HCFC2Host cell factor C2. (792 aa)
CSNK1EProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
RARBRetinoic acid receptor beta. (448 aa)
FOXI2Forkhead box I2. (318 aa)
NCOA2Nuclear receptor coactivator. (1475 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (733 aa)
NPAS3Neuronal PAS domain protein 3. (936 aa)
GPS2G protein pathway suppressor 2. (327 aa)
FOXO6Forkhead box O6. (365 aa)
NUDT12Nudix hydrolase 12. (462 aa)
EPAS1Endothelial PAS domain protein 1. (865 aa)
RXRBRetinoid X receptor beta. (542 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
NMNAT1Nicotinamide-nucleotide adenylyltransferase. (279 aa)
FOXO1Forkhead box O1. (585 aa)
CSNK1DCasein kinase 1 delta. (406 aa)
ISOC2Isochorismatase domain containing 2. (205 aa)
FBXW11F-box and WD repeat domain containing 11. (542 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
NCOR2Nuclear receptor corepressor 2. (2522 aa)
RXRARetinoid X receptor alpha. (481 aa)
MROH6Maestro heat like repeat family member 6. (721 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (514 aa)
LOC104655538Fork-head domain-containing protein. (464 aa)
NMNAT2Nicotinamide nucleotide adenylyltransferase 2. (307 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (370 aa)
LOC104657883AlaDh_PNT_N domain-containing protein. (200 aa)
PER3Period circadian regulator 3. (1178 aa)
FOXK2Forkhead box K2. (592 aa)
NPAS1Neuronal PAS domain protein 1. (591 aa)
CDH19Cadherin 19; Cadherins are calcium-dependent cell adhesion proteins. (772 aa)
USP7Uncharacterized protein; Belongs to the peptidase C19 family. (1102 aa)
OVGP1Oviductal glycoprotein 1; Belongs to the glycosyl hydrolase 18 family. (623 aa)
PLAC8Placenta associated 8. (113 aa)
RORARAR related orphan receptor A. (555 aa)
NCOA3Nuclear receptor coactivator. (1418 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
BCL6BBCL6B transcription repressor. (474 aa)
NMRK2Nicotinamide riboside kinase 2. (230 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
LOC104678360Nuclear receptor domain-containing protein. (231 aa)
AIPPeptidylprolyl isomerase. (330 aa)
ISOC1Isochorismatase domain containing 1. (298 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (511 aa)
TEFTEF transcription factor, PAR bZIP family member. (283 aa)
SIRT7Sirtuin 7. (400 aa)
ENSRROP00000045774Uncharacterized protein. (388 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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