(5 nodes) NEDD8 activating enzyme activity, and Nedd8-like ubiquitin network (Rhinopithecus roxellana)

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Your Input:
	ENSRROP00000003686	Ubiquitin-like domain-containing protein. (81 aa)
	UBE2M	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	NAE1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (538 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (463 aa)
	ENSRROP00000037585	UBIQUITIN_CONJUGAT_2 domain-containing protein. (163 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSRROP00000003686	ENSRROP00000037585	ENSRROP00000003686	ENSRROP00000037585	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.843
ENSRROP00000003686	NAE1	ENSRROP00000003686	ENSRROP00000023530	Ubiquitin-like domain-containing protein.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.956
ENSRROP00000003686	UBA3	ENSRROP00000003686	ENSRROP00000024183	Ubiquitin-like domain-containing protein.	Ubiquitin like modifier activating enzyme 3.	0.965
ENSRROP00000003686	UBE2M	ENSRROP00000003686	ENSRROP00000004320	Ubiquitin-like domain-containing protein.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.969
ENSRROP00000037585	ENSRROP00000003686	ENSRROP00000037585	ENSRROP00000003686	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.843
ENSRROP00000037585	NAE1	ENSRROP00000037585	ENSRROP00000023530	UBIQUITIN_CONJUGAT_2 domain-containing protein.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.869
ENSRROP00000037585	UBA3	ENSRROP00000037585	ENSRROP00000024183	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin like modifier activating enzyme 3.	0.909
ENSRROP00000037585	UBE2M	ENSRROP00000037585	ENSRROP00000004320	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.503
NAE1	ENSRROP00000003686	ENSRROP00000023530	ENSRROP00000003686	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	Ubiquitin-like domain-containing protein.	0.956
NAE1	ENSRROP00000037585	ENSRROP00000023530	ENSRROP00000037585	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.869
NAE1	UBA3	ENSRROP00000023530	ENSRROP00000024183	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	Ubiquitin like modifier activating enzyme 3.	0.999
NAE1	UBE2M	ENSRROP00000023530	ENSRROP00000004320	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.975
UBA3	ENSRROP00000003686	ENSRROP00000024183	ENSRROP00000003686	Ubiquitin like modifier activating enzyme 3.	Ubiquitin-like domain-containing protein.	0.965
UBA3	ENSRROP00000037585	ENSRROP00000024183	ENSRROP00000037585	Ubiquitin like modifier activating enzyme 3.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.909
UBA3	NAE1	ENSRROP00000024183	ENSRROP00000023530	Ubiquitin like modifier activating enzyme 3.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.999
UBA3	UBE2M	ENSRROP00000024183	ENSRROP00000004320	Ubiquitin like modifier activating enzyme 3.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.988
UBE2M	ENSRROP00000003686	ENSRROP00000004320	ENSRROP00000003686	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.969
UBE2M	ENSRROP00000037585	ENSRROP00000004320	ENSRROP00000037585	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.503
UBE2M	NAE1	ENSRROP00000004320	ENSRROP00000023530	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.975
UBE2M	UBA3	ENSRROP00000004320	ENSRROP00000024183	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin like modifier activating enzyme 3.	0.988