53 items (Rhinopithecus roxellana) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HLA-E	Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (364 aa)
	CD28	CD28 molecule. (220 aa)
	IL10	Interleukin 10. (178 aa)
	CLCF1	Cardiotrophin like cytokine factor 1. (319 aa)
	KMT5B	Lysine methyltransferase 5B. (885 aa)
	ENSRROP00000029809	Prohibitin. (264 aa)
	PHB	Prohibitin. (272 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	CD86	CD86 molecule. (329 aa)
	PHB2	Prohibitin. (299 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	TFRC	Transferrin receptor. (760 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	HMCES	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (354 aa)
	IL6	Interleukin 6. (214 aa)
	MZB1	Marginal zone B and B1 cell specific protein. (188 aa)
	RIF1	Replication timing regulatory factor 1. (2471 aa)
	LOC104659533	FAM35_C domain-containing protein. (233 aa)
	IL4R	Interleukin 4 receptor. (825 aa)
	SHLD2	FAM35_C domain-containing protein. (905 aa)
	TP53BP1	Tumor protein p53 binding protein 1. (1976 aa)
	DNAJB9	DnaJ heat shock protein family (Hsp40) member B9. (222 aa)
	KMT5C	Lysine methyltransferase 5C. (461 aa)
	PAXIP1	PAX interacting protein 1. (1075 aa)
	ATAD5	ATPase family AAA domain containing 5. (1834 aa)
	STX4	Syntaxin 4; Belongs to the syntaxin family. (298 aa)
	SHLD1	Shieldin complex subunit 1. (228 aa)
	TNFRSF4	TNF receptor superfamily member 4. (277 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
	LOC104676775	Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (224 aa)
	ENSRROP00000013117	Prohibitin. (179 aa)
	SASH3	SAM and SH3 domain containing 3. (380 aa)
	ENSRROP00000016443	Prohibitin. (112 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	EXOSC3	Exosome component 3. (275 aa)
	BTK	Tyrosine-protein kinase. (690 aa)
	NSD2	Nuclear receptor binding SET domain protein 2. (1365 aa)
	TBX21	T-box transcription factor 21. (531 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1311 aa)
	XBP1	BZIP domain-containing protein. (380 aa)
	IL33	Interleukin 33. (270 aa)
	C17orf99	Chromosome 17 open reading frame 99. (265 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	EPHB2	EPH receptor B2. (1058 aa)
	MLH1	MutL homolog 1. (756 aa)
	CD40	CD40 molecule. (278 aa)
	HPX	Hemopexin. (422 aa)
	CD37	Tetraspanin. (311 aa)
	ENSRROP00000026787	Prohibitin. (190 aa)
	ENSRROP00000028436	Prohibitin. (290 aa)
	IL13	Interleukin 13. (146 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	MAD2L2	ENSRROP00000034862	ENSRROP00000013205	ATPase family AAA domain containing 5.	Mitotic arrest deficient 2 like 2.	0.576
ATAD5	MSH2	ENSRROP00000034862	ENSRROP00000000626	ATPase family AAA domain containing 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.407
BTK	PTPRC	ENSRROP00000019847	ENSRROP00000022085	Tyrosine-protein kinase.	Protein tyrosine phosphatase receptor type C.	0.405
BTK	SASH3	ENSRROP00000019847	ENSRROP00000010322	Tyrosine-protein kinase.	SAM and SH3 domain containing 3.	0.419
BTK	STAT6	ENSRROP00000019847	ENSRROP00000017749	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.476
CD28	CD40	ENSRROP00000041237	ENSRROP00000025363	CD28 molecule.	CD40 molecule.	0.552
CD28	CD86	ENSRROP00000041237	ENSRROP00000008396	CD28 molecule.	CD86 molecule.	0.963
CD28	IL10	ENSRROP00000041237	ENSRROP00000042923	CD28 molecule.	Interleukin 10.	0.591
CD28	IL13	ENSRROP00000041237	ENSRROP00000029441	CD28 molecule.	Interleukin 13.	0.431
CD28	IL2	ENSRROP00000041237	ENSRROP00000009106	CD28 molecule.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.673
CD28	IL5	ENSRROP00000041237	ENSRROP00000006542	CD28 molecule.	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.	0.440
CD28	IL6	ENSRROP00000041237	ENSRROP00000001399	CD28 molecule.	Interleukin 6.	0.422
CD28	PTPRC	ENSRROP00000041237	ENSRROP00000022085	CD28 molecule.	Protein tyrosine phosphatase receptor type C.	0.495
CD28	TBX21	ENSRROP00000041237	ENSRROP00000021230	CD28 molecule.	T-box transcription factor 21.	0.480
CD28	TNFRSF4	ENSRROP00000041237	ENSRROP00000038988	CD28 molecule.	TNF receptor superfamily member 4.	0.614
CD28	TNFSF4	ENSRROP00000041237	ENSRROP00000030801	CD28 molecule.	TNF superfamily member 4; Belongs to the tumor necrosis factor family.	0.697
CD40	CD28	ENSRROP00000025363	ENSRROP00000041237	CD40 molecule.	CD28 molecule.	0.552
CD40	CD86	ENSRROP00000025363	ENSRROP00000008396	CD40 molecule.	CD86 molecule.	0.781
CD40	IL10	ENSRROP00000025363	ENSRROP00000042923	CD40 molecule.	Interleukin 10.	0.587
CD40	IL2	ENSRROP00000025363	ENSRROP00000009106	CD40 molecule.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.569