STRINGSTRING
WBP1 WBP1 E2F7 E2F7 ATF1 ATF1 RBBP6 RBBP6 E2F8 E2F8 MCM4 MCM4 MAP2K4 MAP2K4 DACH1 DACH1 RFC4 RFC4 LOC104654592 LOC104654592 CHRAC1 CHRAC1 WRNIP1 WRNIP1 RUVBL2 RUVBL2 JADE1 JADE1 PCNA PCNA SMARCA5 SMARCA5 ANKRD17 ANKRD17 SSBP1 SSBP1 TIMELESS TIMELESS ZMPSTE24 ZMPSTE24 FBH1 FBH1 RFC3 RFC3 EHMT2 EHMT2 UCHL5 UCHL5 POLG2 POLG2 MCRS1 MCRS1 ATRX ATRX MAS1 MAS1 GINS4 GINS4 ID3 ID3 FBXO5 FBXO5 ZNF830 ZNF830 TSPYL2 TSPYL2 BCL6 BCL6 LIG3 LIG3 STOML2 STOML2 BAZ1A BAZ1A ENSRROP00000004482 ENSRROP00000004482 RUVBL1 RUVBL1 MCIDAS MCIDAS CTC1 CTC1 GMNC GMNC SMC3 SMC3 GDF2 GDF2 LOC104663773 LOC104663773 ZBTB38 ZBTB38 ENPP7 ENPP7 TIPIN TIPIN ENSRROP00000000955 ENSRROP00000000955 INO80D INO80D ENSRROP00000000550 ENSRROP00000000550 INO80B INO80B OBI1 OBI1 NPM2 NPM2 NUCKS1 NUCKS1 DHX9 DHX9 GLI2 GLI2 ACTR8 ACTR8 RFC2 RFC2 ACTR5 ACTR5 ENSRROP00000039966 ENSRROP00000039966 KCTD13 KCTD13 INO80C INO80C CDC7 CDC7 GTPBP4 GTPBP4 CDK2 CDK2 NRM NRM ENSRROP00000014488 ENSRROP00000014488 ING5 ING5 MCM7 MCM7 CIZ1 CIZ1 BLM BLM DSCC1 DSCC1 ORC3 ORC3 MCM6 MCM6 ENSRROP00000029826 ENSRROP00000029826 ZRANB3 ZRANB3 ENSRROP00000030256 ENSRROP00000030256 PPP2R1A PPP2R1A NFRKB NFRKB BRCA2 BRCA2 TERF1 TERF1 DBF4B DBF4B METTL4 METTL4 LOC104659451 LOC104659451 JADE2 JADE2 CDAN1 CDAN1 INO80 INO80 JADE3 JADE3 ENSRROP00000019064 ENSRROP00000019064 MEAF6 MEAF6 ORC5 ORC5 DBF4 DBF4 MCM5 MCM5 GLI1 GLI1 CHTF8 CHTF8 GMNN GMNN CHTF18 CHTF18 BCAR3 BCAR3 ENSRROP00000032433 ENSRROP00000032433 RFC5 RFC5 GINS2 GINS2 TFPT TFPT LPIN1 LPIN1 WIZ WIZ ACTL6A ACTL6A EGF EGF INO80E INO80E KAT7 KAT7 DNA2 DNA2 AICDA AICDA FAF1 FAF1 NUGGC NUGGC ENSRROP00000034537 ENSRROP00000034537 CDC6 CDC6 ESCO1 ESCO1 ATAD5 ATAD5 ESCO2 ESCO2 ENSRROP00000035532 ENSRROP00000035532 ENSRROP00000035959 ENSRROP00000035959 BRPF3 BRPF3 EREG EREG CCNA2 CCNA2 ATR ATR EGFR EGFR GINS1 GINS1 S100A11 S100A11 PPP2CA PPP2CA SMARCAL1 SMARCAL1 POLE3 POLE3 CDT1 CDT1 PDS5A PDS5A TP53 TP53 GINS3 GINS3 LOC104673770 LOC104673770 DONSON DONSON TTF1 TTF1 TICRR TICRR MCM2 MCM2 HCRT HCRT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WBP1WW domain binding protein 1. (302 aa)
E2F7E2F transcription factor 7. (910 aa)
ATF1Activating transcription factor 1. (270 aa)
RBBP6RB binding protein 6, ubiquitin ligase. (1792 aa)
E2F8E2F transcription factor 8. (867 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
DACH1Dachshund family transcription factor 1. (756 aa)
RFC4Replication factor C subunit 4. (363 aa)
LOC104654592WAPL domain-containing protein. (402 aa)
CHRAC1Chromatin accessibility complex subunit 1. (131 aa)
WRNIP1WRN helicase interacting protein 1. (665 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
JADE1Jade family PHD finger 1. (870 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1044 aa)
ANKRD17Ankyrin repeat domain 17. (2603 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
TIMELESSTimeless circadian regulator. (1292 aa)
ZMPSTE24Zinc metallopeptidase STE24. (515 aa)
FBH1F-box DNA helicase 1. (1079 aa)
RFC3Replication factor C subunit 3. (356 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1237 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (395 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (485 aa)
MCRS1Microspherule protein 1. (475 aa)
ATRXUncharacterized protein. (164 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
FBXO5F-box protein 5. (448 aa)
ZNF830Zinc finger protein 830. (386 aa)
TSPYL2TSPY like 2; Belongs to the nucleosome assembly protein (NAP) family. (495 aa)
BCL6BCL6 transcription repressor. (706 aa)
LIG3DNA ligase. (1009 aa)
STOML2Stomatin like 2. (356 aa)
BAZ1ABromodomain adjacent to zinc finger domain 1A. (1556 aa)
ENSRROP00000004482Uncharacterized protein. (159 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
MCIDASMulticiliate differentiation and DNA synthesis associated cell cycle protein. (385 aa)
CTC1CST telomere replication complex component 1. (1217 aa)
GMNCGeminin coiled-coil domain containing. (334 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
GDF2Growth differentiation factor 2. (429 aa)
LOC104663773Protein S100; Belongs to the S-100 family. (105 aa)
ZBTB38Zinc finger and BTB domain containing 38. (1195 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (450 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (307 aa)
ENSRROP00000000955CBFD_NFYB_HMF domain-containing protein. (54 aa)
INO80DINO80 complex subunit D. (1027 aa)
ENSRROP00000000550Protein kinase domain-containing protein. (340 aa)
INO80BPAPA-1 domain-containing protein. (373 aa)
OBI1ORC ubiquitin ligase 1. (726 aa)
NPM2Nucleophosmin/nucleoplasmin 2. (214 aa)
NUCKS1Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa)
DHX9DExH-box helicase 9. (1275 aa)
GLI2GLI family zinc finger 2. (1586 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
RFC2Replication factor C subunit 2. (332 aa)
ACTR5Actin related protein 5; Belongs to the actin family. (515 aa)
ENSRROP00000039966S_100 domain-containing protein; Belongs to the S-100 family. (97 aa)
KCTD13Potassium channel tetramerization domain containing 13. (329 aa)
INO80CINO80 complex subunit C. (228 aa)
CDC7Protein kinase domain-containing protein. (574 aa)
GTPBP4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (362 aa)
NRMNurim. (262 aa)
ENSRROP00000014488Protein kinase domain-containing protein. (549 aa)
ING5Inhibitor of growth family member 5. (254 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (626 aa)
CIZ1CDKN1A interacting zinc finger protein 1. (947 aa)
BLMBLM RecQ like helicase. (1416 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (416 aa)
ORC3Origin recognition complex subunit 3. (715 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
ENSRROP00000029826DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (174 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1006 aa)
ENSRROP00000030256Calponin-homology (CH) domain-containing protein. (117 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
NFRKBNuclear factor related to kappaB binding protein. (1299 aa)
BRCA2BRCA2 DNA repair associated. (3418 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa)
DBF4BDBF4 zinc finger B. (435 aa)
METTL4Methyltransferase like 4; Belongs to the MT-A70-like family. (480 aa)
LOC104659451Uncharacterized protein. (99 aa)
JADE2Jade family PHD finger 2. (833 aa)
CDAN1Codanin 1. (1227 aa)
INO80INO80 complex ATPase subunit. (1556 aa)
JADE3Jade family PHD finger 3. (823 aa)
ENSRROP00000019064Uncharacterized protein. (123 aa)
MEAF6Uncharacterized protein. (262 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
DBF4DBF4 zinc finger. (673 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
GLI1GLI family zinc finger 1. (1106 aa)
CHTF8Chromosome transmission fidelity factor 8. (121 aa)
GMNNGeminin DNA replication inhibitor. (209 aa)
CHTF18Chromosome transmission fidelity factor 18. (999 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (825 aa)
ENSRROP00000032433TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (294 aa)
RFC5Replication factor C subunit 5. (340 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
TFPTTCF3 fusion partner. (263 aa)
LPIN1Lipin 1. (945 aa)
WIZWIZ zinc finger. (968 aa)
ACTL6AActin like 6A; Belongs to the actin family. (429 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1233 aa)
INO80EINO80 complex subunit E. (244 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (506 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
AICDAActivation induced cytidine deaminase. (199 aa)
FAF1Fas associated factor 1. (635 aa)
NUGGCNuclear GTPase, germinal center associated. (796 aa)
ENSRROP00000034537Sld5 domain-containing protein. (151 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
ESCO1Establishment of sister chromatid cohesion N-acetyltransferase 1. (840 aa)
ATAD5ATPase family AAA domain containing 5. (1834 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (601 aa)
ENSRROP00000035532Protein S100; Belongs to the S-100 family. (111 aa)
ENSRROP00000035959Uncharacterized protein. (654 aa)
BRPF3Bromodomain and PHD finger containing 3. (1205 aa)
EREGEpiregulin. (163 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2578 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
GINS1GINS complex subunit 1. (196 aa)
S100A11S100 calcium binding protein A11. (105 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (949 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
CDT1Chromatin licensing and DNA replication factor 1. (513 aa)
PDS5APDS5 cohesin associated factor A. (1337 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
GINS3GINS complex subunit 3. (255 aa)
LOC104673770Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (237 aa)
DONSONDownstream neighbor of SON. (564 aa)
TTF1Transcription termination factor 1. (880 aa)
TICRRTOPBP1 interacting checkpoint and replication regulator. (1908 aa)
MCM2DNA helicase; Belongs to the MCM family. (907 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (131 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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