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| | LOC104654105 | Kin17_mid domain-containing protein. (393 aa) |
| | AICDA | Activation induced cytidine deaminase. (199 aa) |
| | HSF2BP | Heat shock transcription factor 2 binding protein. (305 aa) |
| | POGZ | Pogo transposable element derived with ZNF domain. (1418 aa) |
| | FANCD2 | Uncharacterized protein. (1425 aa) |
| | APEX2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | INTS3 | Integrator complex subunit 3. (1109 aa) |
| | ENSRROP00000016927 | Uncharacterized protein. (194 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (621 aa) |
| | RAD21L1 | RAD21 cohesin complex component like 1. (556 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | SWI5 | Uncharacterized protein. (72 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |
| | ENSRROP00000015112 | Uncharacterized protein. (63 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (908 aa) |
| | SWAP70 | Switching B cell complex subunit SWAP70. (585 aa) |
| | ENSRROP00000014674 | Uncharacterized protein. (235 aa) |
| | ENSRROP00000014488 | Protein kinase domain-containing protein. (549 aa) |
| | RAD51B | RAD51 paralog B. (279 aa) |
| | LOC104677903 | Uncharacterized protein. (753 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (396 aa) |
| | FSBP | Uncharacterized protein. (908 aa) |
| | CCDC36 | Coiled-coil domain containing 36. (599 aa) |
| | RAD51AP2 | RAD51 associated protein 2. (1159 aa) |
| | ENSRROP00000032863 | Uncharacterized protein. (227 aa) |
| | LOC104673998 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (399 aa) |
| | EPC1 | Enhancer of polycomb homolog. (836 aa) |
| | AUNIP | Aurora kinase A and ninein interacting protein. (364 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1836 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | MSH4 | MutS homolog 4. (935 aa) |
| | REC8 | REC8 meiotic recombination protein. (522 aa) |
| | SETX | Senataxin. (2678 aa) |
| | TFPT | TCF3 fusion partner. (263 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | ENSRROP00000034208 | Uncharacterized protein. (177 aa) |
| | ENSRROP00000034537 | Sld5 domain-containing protein. (151 aa) |
| | PAXIP1 | PAX interacting protein 1. (1075 aa) |
| | RECQL4 | RecQ like helicase 4. (1150 aa) |
| | RPA2 | Replication protein A2. (273 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1834 aa) |
| | SFPQ | Splicing factor proline and glutamine rich. (585 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1140 aa) |
| | BATF | Basic leucine zipper ATF-like transcription factor. (125 aa) |
| | SHOC1 | Shortage in chiasmata 1. (1444 aa) |
| | UBR2 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa) |
| | CD40LG | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (773 aa) |
| | RPAIN | RPA interacting protein. (219 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (313 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (907 aa) |
| | ENSRROP00000038012 | Uncharacterized protein. (186 aa) |
| | DEF6 | DEF6 guanine nucleotide exchange factor. (631 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | SEM1-2 | Uncharacterized protein. (89 aa) |
| | TCF7 | Transcription factor 7. (469 aa) |
| | ENSRROP00000038482 | Uncharacterized protein. (282 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | TRIP13 | Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (432 aa) |
| | RHNO1 | Uncharacterized protein. (240 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa) |
| | ACTR5 | Actin related protein 5; Belongs to the actin family. (515 aa) |
| | ENSRROP00000039532 | Uncharacterized protein. (202 aa) |
| | NONO | Non-POU domain containing octamer binding. (471 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (580 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa) |
| | LOC104662867 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (112 aa) |
| | NABP1 | Nucleic acid binding protein 1. (204 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (322 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (379 aa) |
| | NABP2 | Nucleic acid binding protein 2. (211 aa) |
| | ENSRROP00000041768 | Kin17_mid domain-containing protein. (341 aa) |
| | REC114 | REC114 meiotic recombination protein. (265 aa) |
| | SYCE3 | Synaptonemal complex central element protein 3. (88 aa) |
| | NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa) |
| | RNF212 | Ring finger protein 212. (232 aa) |
| | MND1 | Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (208 aa) |
| | C14orf39 | Chromosome 14 open reading frame 39. (585 aa) |
| | HELQ | Helicase, POLQ like. (1101 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4159 aa) |
| | WRN | WRN RecQ like helicase. (1431 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (281 aa) |
| | HFM1 | Helicase for meiosis 1. (1435 aa) |
| | SYCP1 | Synaptonemal complex protein 1. (976 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (584 aa) |
| | POLN | DNA polymerase nu. (880 aa) |
| | KIN | Kin17_mid domain-containing protein. (393 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (703 aa) |
| | MSH3 | MutS homolog 3. (1195 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | CCR6 | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (377 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1249 aa) |
| | BCL11B | BAF chromatin remodeling complex subunit BCL11B. (870 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3128 aa) |
| | SEM1 | SEM1 26S proteasome complex subunit. (110 aa) |
| | CDC7 | Protein kinase domain-containing protein. (574 aa) |
| | INO80C | INO80 complex subunit C. (228 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (266 aa) |
| | ENSRROP00000012448 | Uncharacterized protein. (77 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (334 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (617 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | CDC45 | Cell division cycle 45. (598 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (419 aa) |
| | TOP2B | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1622 aa) |
| | MLH3 | MutL homolog 3. (1456 aa) |
| | WDR48 | WD repeat domain 48. (700 aa) |
| | FBH1 | F-box DNA helicase 1. (1079 aa) |
| | AP5S1 | Adaptor related protein complex 5 subunit sigma 1. (200 aa) |
| | FANCM | FA complementation group M. (2050 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1034 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1815 aa) |
| | ENSRROP00000008753 | Uncharacterized protein. (57 aa) |
| | ENSRROP00000008346 | Uncharacterized protein. (190 aa) |
| | CCDC155 | Coiled-coil domain containing 155. (562 aa) |
| | MCRS1 | Microspherule protein 1. (475 aa) |
| | SMC5 | SMC_N domain-containing protein. (1102 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (752 aa) |
| | NIPBL | Nipped-B protein. (2804 aa) |
| | SPIDR | DUF4503 domain-containing protein. (397 aa) |
| | LOC104655330 | Uncharacterized protein. (200 aa) |
| | ENSRROP00000006988 | Kin17_mid domain-containing protein. (390 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | PAGR1 | PAXIP1 associated glutamate rich protein 1. (254 aa) |
| | INIP | INTS3 and NABP interacting protein. (104 aa) |
| | C19orf57 | Chromosome 19 open reading frame 57. (677 aa) |
| | ENSRROP00000006044 | Kin17_mid domain-containing protein. (393 aa) |
| | SFR1 | SWI5 dependent homologous recombination repair protein 1. (245 aa) |
| | BCL6 | BCL6 transcription repressor. (706 aa) |
| | LOC104665503 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1243 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | LIG3 | DNA ligase. (1009 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1092 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | ENSRROP00000005185 | Uncharacterized protein. (120 aa) |
| | ENSRROP00000005112 | Uncharacterized protein. (271 aa) |
| | RAD54L | RAD54 like. (747 aa) |
| | C11orf80 | Chromosome 11 open reading frame 80. (511 aa) |
| | SWSAP1 | SWIM-type zinc finger 7 associated protein 1. (250 aa) |
| | C1orf146 | Chromosome 1 open reading frame 146. (180 aa) |
| | CCNB1IP1 | RING-type domain-containing protein. (277 aa) |
| | ENSRROP00000004045 | DUF4502 domain-containing protein. (198 aa) |
| | LOC104677852 | Uncharacterized protein. (200 aa) |
| | LOC104664221 | Uncharacterized protein. (240 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (898 aa) |
| | RNF212B | Ring finger protein 212B. (300 aa) |
| | KIAA1841 | KIAA1841. (718 aa) |
| | ZFYVE26 | Zinc finger FYVE-type containing 26. (2522 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa) |
| | ENSRROP00000002311 | Ku domain-containing protein. (539 aa) |
| | CYREN | Cell cycle regulator of NHEJ. (159 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (689 aa) |
| | RAD51C | RAD51 paralog C. (367 aa) |
| | LOC104654245 | Uncharacterized protein. (243 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | ENSRROP00000001331 | Kin17_mid domain-containing protein. (391 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | ENSRROP00000001202 | RRM domain-containing protein. (172 aa) |
| | RAG2 | Recombination activating 2. (527 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (352 aa) |
| | INO80D | INO80 complex subunit D. (1027 aa) |
| | ENSRROP00000000782 | Metallophos domain-containing protein. (229 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (669 aa) |
| | DCAF1 | DDB1 and CUL4 associated factor 1. (1507 aa) |
| | SUPV3L1 | Suv3 like RNA helicase. (787 aa) |
| | CENPS-CORT | CENPS-CORT readthrough. (143 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (385 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (347 aa) |
| | CENPX | Centromere protein X. (133 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (277 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa) |
| | INO80E | INO80 complex subunit E. (244 aa) |
| | HROB | Chromosome 17 open reading frame 53. (646 aa) |
| | RMI2 | Uncharacterized protein. (83 aa) |
| | ACTL6A | Actin like 6A; Belongs to the actin family. (429 aa) |
| | FANCB | FA complementation group B. (859 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | ENSRROP00000022479 | SP-RING-type domain-containing protein. (210 aa) |
| | HDAC10 | Histone deacetylase 10. (673 aa) |
| | ENSRROP00000027818 | Uncharacterized protein. (266 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (626 aa) |
| | ENSRROP00000027580 | Uncharacterized protein. (220 aa) |
| | NSMCE2 | SP-RING-type domain-containing protein. (246 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | RPA3 | Uncharacterized protein. (121 aa) |
| | TEP1 | Telomerase associated protein 1. (2628 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1378 aa) |
| | LOC104678031 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | ENSRROP00000025981 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (140 aa) |
| | LOC104680609 | Uncharacterized protein. (198 aa) |
| | KLHDC3 | Kelch domain containing 3. (417 aa) |
| | MLH1 | MutL homolog 1. (756 aa) |
| | TPRKB | TP53RK binding protein; Belongs to the CGI121/TPRKB family. (213 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (392 aa) |
| | LOC104679892 | BRCT domain-containing protein. (96 aa) |
| | PGBD5 | PiggyBac transposable element derived 5. (459 aa) |
| | TM4SF19 | Uncharacterized protein. (295 aa) |
| | LOC104680738 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | BLM | BLM RecQ like helicase. (1416 aa) |
| | HDGFL2 | HDGF like 2. (656 aa) |
| | ENSRROP00000028705 | Uncharacterized protein. (346 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1184 aa) |
| | ANKRD31 | Ankyrin repeat domain 31. (1809 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | ENSRROP00000029826 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (174 aa) |
| | FOXP3 | Forkhead box P3. (454 aa) |
| | UBE2N | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1299 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1299 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3418 aa) |
| | LIG1 | DNA ligase. (919 aa) |
| | MEI4 | Meiotic double-stranded break formation protein 4. (256 aa) |
| | MBTD1 | Mbt domain containing 1. (628 aa) |
| | CNTD1 | Cyclin N-terminal domain containing 1. (330 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | ENSRROP00000021812 | Uncharacterized protein. (161 aa) |
| | ZSWIM7 | Zinc finger SWIM-type containing 7. (140 aa) |
| | EXO1 | Exonuclease 1. (846 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (315 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (628 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1017 aa) |
| | PSMC3IP | PSMC3 interacting protein. (217 aa) |
| | LOC104669796 | Uncharacterized protein. (316 aa) |
| | HMGB3 | High mobility group box 3. (200 aa) |
| | EXOSC3 | Exosome component 3. (275 aa) |
| | MSH5 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (834 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | HMGB1 | Uncharacterized protein. (215 aa) |
| | AP5Z1 | Adaptor related protein complex 5 subunit zeta 1. (807 aa) |
| | TCF3 | Transcription factor 3. (655 aa) |
| | INO80 | INO80 complex ATPase subunit. (1556 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1058 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | LOC104659451 | Uncharacterized protein. (99 aa) |
