STRINGSTRING
TGFB1 TGFB1 HIF1A HIF1A IL6 IL6 ATF4 ATF4 CYP1B1 CYP1B1 ISL1 ISL1 CCBE1 CCBE1 SULF1 SULF1 CXCL17 CXCL17 BSG BSG ARNT ARNT ADORA2B ADORA2B C5AR1 C5AR1 HPSE HPSE LOC104679892 LOC104679892 FLT4 FLT4 NOX1 NOX1 C5 C5 NODAL NODAL EIF2AK3 EIF2AK3 BRCA1 BRCA1 PTGS2 PTGS2 IL1B IL1B GATA4 GATA4 C3 C3 RORA RORA SULF2 SULF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
IL6Interleukin 6. (214 aa)
ATF4Activating transcription factor 4. (351 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
ISL1ISL LIM homeobox 1. (349 aa)
CCBE1Collagen and calcium binding EGF domains 1. (428 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
CXCL17C-X-C motif chemokine ligand 17. (119 aa)
BSGBasigin (Ok blood group). (362 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (844 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (331 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
HPSEHeparanase. (545 aa)
LOC104679892BRCT domain-containing protein. (96 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1365 aa)
NOX1NADPH oxidase 1. (564 aa)
C5Complement C5. (950 aa)
NODALNodal growth differentiation factor. (347 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1836 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
GATA4GATA binding protein 4. (417 aa)
C3Complement C3. (1663 aa)
RORARAR related orphan receptor A. (555 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (870 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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