STRINGSTRING
IQSEC1 IQSEC1 HIF1A HIF1A FOXC2 FOXC2 ALOX12 ALOX12 LOC104655302 LOC104655302 HDAC7 HDAC7 PDGFB PDGFB STAT5A STAT5A AKT1 AKT1 PDPK1 PDPK1 DOCK1 DOCK1 TGFBR2 TGFBR2 TACR1 TACR1 FGF16 FGF16 GRN GRN ETS1 ETS1 FGF10 FGF10 RRAS RRAS LOC104674527 LOC104674527 ENPP2 ENPP2 ARF6 ARF6 RTN4 RTN4 RIN2 RIN2 ZNF580 ZNF580 CTSH CTSH RHOB RHOB DOCK5 DOCK5 RAB25 RAB25 PRKCE PRKCE TEK TEK SP1 SP1 VEGFC VEGFC BMPR2 BMPR2 SASH1 SASH1 JCAD JCAD HBEGF HBEGF CCBE1 CCBE1 ADGRA2 ADGRA2 PIK3CD PIK3CD PLK2 PLK2 CLASP2 CLASP2 EPB41L5 EPB41L5 CCR6 CCR6 HYAL1 HYAL1 PRKD1 PRKD1 ANXA3 ANXA3 HDAC9 HDAC9 ATOH8 ATOH8 PIK3CG PIK3CG WNT5A WNT5A BCAR1 BCAR1 ENSRROP00000015812 ENSRROP00000015812 ENSRROP00000015874 ENSRROP00000015874 FGF7 FGF7 PROX1 PROX1 ABL1 ABL1 BSG BSG CAPN7 CAPN7 RHOJ RHOJ MMP9 MMP9 EMC10 EMC10 IRS2 IRS2 IFNG IFNG EPB41L4B EPB41L4B AAMP AAMP SPARC SPARC LOC104674202 LOC104674202 HAS2 HAS2 FGF1 FGF1 SRC SRC SCARB1 SCARB1 MAP4K4 MAP4K4 SIRT1 SIRT1 NOS3 NOS3 MAPRE2 MAPRE2 AKT3 AKT3 NUS1 NUS1 GPLD1 GPLD1 BCAS3 BCAS3 PRKD2 PRKD2 ROCK2 ROCK2 ITGB3 ITGB3 EGF EGF GATA3 GATA3 TSTA3 TSTA3 ENSRROP00000024190 ENSRROP00000024190 KDR KDR PLCG1 PLCG1 FLT4 FLT4 MAP2K3 MAP2K3 ATP5F1B ATP5F1B SEMA5A SEMA5A MTOR MTOR FGFR1 FGFR1 CD40 CD40 NRP1 NRP1 SMOC2 SMOC2 SOX9 SOX9 ZC3H12A ZC3H12A FGF17 FGF17 ADAM17 ADAM17 SRPX2 SRPX2 GLIPR2 GLIPR2 RREB1 RREB1 HSPB1 HSPB1 AMOT AMOT ADAM9 ADAM9 TGFB2 TGFB2 PTGS2 PTGS2 MAP3K3 MAP3K3 NRP2 NRP2 TDGF1 TDGF1 ANGPT4 ANGPT4 P2RX4 P2RX4 VIL1 VIL1 BMP4 BMP4 HMOX1 HMOX1 FGF2 FGF2 ITGA2 ITGA2 CLASP1 CLASP1 ANXA1 ANXA1 CIB1 CIB1 MET MET PTK2B PTK2B GATA2 GATA2 PLPP3 PLPP3 TGFB1 TGFB1 HDAC6 HDAC6 AGT AGT VEGFA VEGFA ITGB1BP1 ITGB1BP1 ANGPT1 ANGPT1 FGF18 FGF18 ITGA3 ITGA3 PRKCA PRKCA WNT7A WNT7A CALR CALR THBS1 THBS1 LGMN LGMN PIK3CB PIK3CB FOXP1 FOXP1 PPM1F PPM1F PLCG2 PLCG2 NFE2L2 NFE2L2 ATP5F1A ATP5F1A ENSRROP00000045667 ENSRROP00000045667
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IQSEC1IQ motif and Sec7 domain 1. (1129 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
FOXC2Forkhead box C2. (501 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
LOC104655302SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1021 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
STAT5ASignal transducer and activator of transcription. (905 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (356 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1870 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
GRNGranulin precursor. (593 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RRASRAS related. (218 aa)
LOC104674527Uncharacterized protein. (899 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (940 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
RTN4Reticulon. (1138 aa)
RIN2Ras and Rab interactor 2. (862 aa)
ZNF580Zinc finger protein 580. (172 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
RHOBRas homolog family member B. (196 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1870 aa)
RAB25RAB25, member RAS oncogene family. (213 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
SP1Sp1 transcription factor. (786 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1002 aa)
SASH1SAM and SH3 domain containing 1. (1230 aa)
JCADJunctional cadherin 5 associated. (1357 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
CCBE1Collagen and calcium binding EGF domains 1. (428 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1284 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
CLASP2Uncharacterized protein. (1517 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (732 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (377 aa)
HYAL1Hyaluronidase. (435 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (895 aa)
ANXA3Annexin. (323 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa)
ATOH8Atonal bHLH transcription factor 8. (364 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
ENSRROP00000015812Uncharacterized protein. (482 aa)
ENSRROP00000015874EGF-like domain-containing protein. (153 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PROX1Prospero homeobox 1. (737 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
BSGBasigin (Ok blood group). (362 aa)
CAPN7Calpain 7; Belongs to the peptidase C2 family. (813 aa)
RHOJRas homolog family member J. (214 aa)
MMP9Matrix metallopeptidase 9. (703 aa)
EMC10ER membrane protein complex subunit 10. (346 aa)
IRS2Insulin receptor substrate 2. (1006 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
EPB41L4BErythrocyte membrane protein band 4.1 like 4B. (900 aa)
AAMPAngio associated migratory cell protein. (434 aa)
SPARCSecreted protein acidic and cysteine rich. (341 aa)
LOC104674202PID domain-containing protein. (184 aa)
HAS2Hyaluronan synthase 2. (460 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
SRCTyrosine-protein kinase. (540 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4. (1345 aa)
SIRT1Sirtuin 1. (746 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
MAPRE2Microtubule associated protein RP/EB family member 2. (327 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (841 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1383 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1233 aa)
GATA3GATA binding protein 3. (444 aa)
TSTA3Tissue specific transplantation antigen P35B. (321 aa)
ENSRROP00000024190Protein kinase domain-containing protein. (137 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1303 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1365 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (535 aa)
SEMA5ASemaphorin 5A. (1056 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
FGFR1Fibroblast growth factor receptor. (872 aa)
CD40CD40 molecule. (278 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
SMOC2SPARC related modular calcium binding 2. (457 aa)
SOX9SRY-box transcription factor 9. (509 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
SRPX2Sushi repeat containing protein X-linked 2. (465 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (165 aa)
RREB1Ras responsive element binding protein 1. (1738 aa)
HSPB1SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
AMOTAngiomotin. (1086 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (647 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (187 aa)
ANGPT4Angiopoietin 4. (503 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
VIL1Villin 1. (827 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HMOX1Heme oxygenase 1. (303 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (263 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1151 aa)
CLASP1Cytoplasmic linker associated protein 1. (1552 aa)
ANXA1Annexin. (346 aa)
CIB1Calcium and integrin binding 1. (191 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1405 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1058 aa)
GATA2GATA binding protein 2. (480 aa)
PLPP3acidPPc domain-containing protein. (326 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
HDAC6Histone deacetylase 6. (1258 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
ITGB1BP1PID domain-containing protein. (154 aa)
ANGPT1Angiopoietin 1. (498 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
CALRCalreticulin. (417 aa)
THBS1Thrombospondin 1. (1170 aa)
LGMNLegumain. (433 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
FOXP1Forkhead box P1. (694 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (454 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (641 aa)
ENSRROP00000045667Uncharacterized protein. (117 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
Server load: low (12%) [HD]